Biological semi-fluid processing assembly

• US 5,302,299 A
• Filed: 03/20/1992
• Issued: 04/12/1994
• Est. Priority Date: 05/24/1990
• Status: Expired due to Term

• Current Assignee: Pall Corporation (Danaher Corporation)
• Original Assignee: Pall Corporation (Danaher Corporation)
• Inventors: Bormann, Thomas J., Matkovich, Vlado I., Pascale, Frank R.
• Primary Examiner(s): Spear, Frank
• Application Number:
  US07/854,588
• Time in Patent Office: 753 Days
• Field of Search: 436/18, 210/436, 210/472, 210/651, 210/652, 210/772, 210/767, 530/395, 435/34
• US Class Current: 210/767
• CPC Class Codes: A61M 1/0209 Multiple bag systems for separating or storing blood components
• CPC Class Codes: A61M 1/0218 with filters
• CPC Class Codes: A61M 1/0231 with gas separating means, e.g. air outlet through microporous membrane or gas bag
• CPC Class Codes: A61M 1/3643 Priming, rinsing before or after use
• CPC Class Codes: A61M 1/3644 Mode of operation
• CPC Class Codes: A61M 1/3646 Expelling the residual body fluid after use, e.g. back to the body
• CPC Class Codes: A61M 1/3652 using gas, e.g. air
• CPC Class Codes: A61M 2202/0007 introduced into the body
• CPC Class Codes: A61M 2202/0042 filtrate, i.e. the fluid passing through the filter
• CPC Class Codes: A61M 2202/0057 retained by adsorption
• CPC Class Codes: A61M 2202/0429 Red blood cells; Erythrocytes
• CPC Class Codes: A61M 2202/0439 White blood cells; Leucocytes lymphocytes A61M2202/0407
• CPC Class Codes: A61M 2205/7527 liquophilic, hydrophilic
• CPC Class Codes: A61M 2205/7536 allowing gas passage, but preventing liquid passage, e.g. liquophobic, hydrophobic, water-repellent membranes
• CPC Class Codes: A61M 5/38 using hydrophilic or hydrophobic filters
• CPC Class Codes: B01D 19/0031 by filtration
• CPC Class Codes: B01D 5/0054 General arrangements, e.g. flow sheets

Abstract

The invention involves a method and apparatus for treating and administering biological fluids, particularly hyperconcentrated biological fluids.

Claims

1. A method for treating a biological semi-fluid comprising

diluting the biological semi-fluid with a physiologically acceptable diluent;

and

removing leukocytes from the diluted biological semi-fluid by passing the diluted biological semifluid through a filter assembly which removes leukocytes from the biological semi-fluid; and

,

separating a substantial portion of the diluent from the leuococyte depleted biological semi-fluid.

2. The method of claim 1 wherein treating a biological semi-fluid comprises treating a red cell containing fluid.

3. The method of claim 2 wherein treating a biological semi-fluid comprises treating packed red cells having a high hematocrit.

4. The method of claim 3 wherein treating a biological semi-fluid comprises treating a biological semi-fluid having a hematocrit above about 80%.

5. The method of claim 1 further comprising removing gas from a treatment apparatus.

6. The method of claim 5 wherein removing gas from the treatment apparatus comprises venting the gas through a gas outlet.

7. The method of claim 6 wherein removing gas from the treatment apparatus comprises venting gas displaced by diluent.

8. The method of claim 5 wherein removing gas from the treatment apparatus comprises priming the leucocyte depletion filter assembly.

9. The method of claim 8 wherein removing gas from the treatment apparatus comprises venting gas displaced by diluent.

10. The method of claim 1 further comprising recovering the leucocyte depleted diluted biological semi-fluid.

11. The method of claim 10 wherein recovering the leucocyte depleted diluted biological semi-fluid includes recovering biological semi-fluid in the filter assembly.

12. The method of claim 11 wherein recovering the leucocyte depleted diluted biological semi-fluid comprises opening a gas inlet to allow air to enter the apparatus.

13. The method of claim 1 further comprising administering the leukocyte depleted biological semi-fluid.

14. A method for treating a high hematocrit biological semi-fluid comprising

diluting a red cell containing biological semi-fluid with a physiologically acceptable diluent;

removing leukocytes from the diluted biological semi-fluid by passing the red cell containing biological semi-fluid through a leucocyte depletion filter assembly;

separating a substantial portion of the diluent from the leucocyte depleted biological semi-fluid.

15. The method of claim 14 further comprising priming the leucocyte depletion filter assembly and venting gas from a treatment apparatus.

16. The method of claim 14 wherein separating a substantial portion of the diluent comprises removing sufficient diluent so that the biological semi-fluid has a hematocrit above about 80%.

17. The method of claim 14 further comprising administering the leukocyte depleted biological semi-fluid.