Process for dry sterilization of medical devices and materials

• US 5,302,343 A
• Filed: 04/02/1993
• Issued: 04/12/1994
• Est. Priority Date: 02/25/1987
• Status: Expired due to Term

• Current Assignee: Ethicon Incorporated (Johnson & Johnson)
• Original Assignee: Adir Jacob
• Inventors: Jacob, Adir
• Primary Examiner(s): ALEXANDER, LYLE
• Application Number:
  US08/042,136
• Time in Patent Office: 375 Days
• Field of Search: 422/21-23, 422/28, 422/33, 422/36, 422/37, 204/164, 204/298, 250/424, 250/455.1, 250/492.1
• US Class Current: 422/23
• CPC Class Codes: A61L 2/12 Microwaves
• CPC Class Codes: A61L 2/14 Plasma, i.e. ionised gases

Abstract

Articles to be sterilized are placed into a confined volume and are subjected to neutral species of an electrical discharge while maintaining the volume glowless and substantially field free by interposing a barrier between the articles and the discharge, the barrier being transparent to neutral species and opaque to charged species emanating from the discharge.

Claims

1. A method for sterilization of articles comprising the steps of:

placing said articles within an electrically conductive perforated electrode, said electrode being positioned within, and spaced apart from, a gas-tight confining chamber, said chamber being formed from electrically conductive material and connected to a point of potential reference;

evacuating said chamber to a substantially low pressure and introducing a gas into said chamber;

initiating an electrical discharge in said gas within said chamber by application of an electric field between said internal perforated electrode and the electrically conductive chamber wall, creating a gas plasma, having a substantially field free and glowless volume within the confines of the perforated electrode containing said articles, whereby said articles are contacted by substantially electrically neutral active species at a temperature below that which would be detrimental to said articles; and

maintaining said gas plasma for a controlled period of time.

2. A method in accordance with claim 1 wherein said gas is an oxidizing gas.

3. A method in accordance with claim 1 wherein said gas is a reducing gas.

4. A method in accordance with claim 1 and further including a second perforated electrically conductive electrode positioned between said chamber wall and said first perforated metallic electrode, said first perforated electrode and said chamber wall both being electrically connected to a point of potential reference, said electric field being applied between said second perforated electrode and said point of potential reference.

5. A method for sterilization of articles enclosed within sealed pouches formed of a gas permeable material comprising the steps of:

placing said pouches containing said articles to be sterilized within an electrically conductive positioned within, and spaced apart from a gas-tight confining chamber, said chamber formed from electrically conductive material and connected to a point of potential reference;

evacuating said chamber to a substantially low pressure and introducing a gas into said chamber;

initialing an electrical discharge in said gas within said chamber by application of an electric field between said internal perforated electrode and the electrically conductive chamber wall, thereby creating a substantially field free and glowless volume within the perforated electrode containing said pouches, whereby said articles are contacted by substantially electrically neutral active species at a temperature below that which would be detrimental to said articles; and

maintaining said electrical discharge for a controlled period of time.

6. A method in accordance with claim 5 wherein said gas is an oxidizing gas.

7. A method in accordance with claim 5 wherein said gas is a reducing gas.

8. A method in accordance with claim 5 and further including a second perforated electrically conductive electrode positioned between said chamber wall and said first perforated metallic electrode, said first perforated electrode and said chamber wall both being electrically connected to a point of potential reference, said electric field being applied between said second perforated electrode and said point of potential reference.

9. A method for sterilization and treatment of medical and dental articles comprising the steps of:

placing said articles within a metallic perforated electrode, said electrode being positioned within, and spaced from, a gas-tight confining chamber;

evacuating said chamber to a substantially low pressure and introducing a gas into said chamber;

initiating an electrical discharge in said gas within said chamber by application of an RF voltage to said internal perforated electrode and across said chamber wall, creating a gas plasma accompanied by a substantially field-free and glowless volume within the perforated electrode containing said articles, whereby said articles are contacted by a substantially electrically neutral active species at a temperature below that which would be detrimental to said articles; and

maintaining said gas plasma for a controlled period of time.

10. A method in accordance with claim 9 wherein said gas-tight chamber is formed of metal and is connected to a point of potential reference.

11. A method for sterilization of articles, comprising the steps of:

placing said articles within an electrically conductive perforated electrode, said electrode being positioned within, and spaced apart from, a gas-tight confining chamber, said chamber being formed from electrically conductive material and connected to a point of potential reference;

evacuating said chamber to a substantially low pressure and introducing a gas into said chamber;

initiating an electrical discharge in said gas within said chamber by application of an electric field between said internal perforated electrode and the electrically conductive chamber wall, thereby creating a substantially field free and glowless volume within the perforated electrode containing said articles, whereby said articles are contacted by substantially electrically neutral active species at a temperature below that which would be detrimental to said articles;

maintaining said electrical discharge for a controlled period of time; and

maintaining a flow of said gas through said chamber during said electrical discharge.

12. A method for sterilization and treatment of articles, comprising the steps of:

placing said articles within a first metallic perforated electrode, said electrode being positioned within, and spaced from, a gas-tight confining chamber;

evacuating said chamber to a substantially low pressure and introducing a gas into said chamber;

initiating an electrical discharge in said gas within said chamber, by application of an RF voltage to said internal perforated electrode and across said chamber wall, thereby effecting a substantially field-free and glowless volume within the perforated electrode containing said articles, whereby said articles are contacted by a substantially electrically neutral active species at a temperature below that which would be detrimental to said articles;

maintaining said electrical discharge for a controlled period of time; and

maintaining a flow of said gas through said chamber.