Reagent container for analytical rotor

• US 5,304,348 A
• Filed: 02/11/1992
• Issued: 04/19/1994
• Est. Priority Date: 02/11/1992
• Status: Expired due to Term

• Current Assignee: Abaxis Incorporated (Zoetis Incorporated)
• Original Assignee: Abaxis Incorporated (Zoetis Incorporated)
• Inventors: Schembri, Carol T., Burd, Tammy L.
• Primary Examiner(s): Housel, James C.
• Assistant Examiner(s): Carpenter, Robert
• Application Number:
  US07/833,689
• Time in Patent Office: 798 Days
• Field of Search: 422/72, 422/64, 422/102, 436/45, 494/31, 494/45, 222/81, 222/83, 222/167, 222/541
• US Class Current: 422/72
• CPC Class Codes: G01N 2035/00495 Centrifuges
• CPC Class Codes: G01N 2035/0405 manipulating closing or opening means, e.g. stoppers, screw caps, lids or covers
• CPC Class Codes: G01N 21/07 Centrifugal type cuvettes G01N21/09 takes precedence
• CPC Class Codes: G01N 33/491 by separating the blood components G01N15/05 takes precedence
• CPC Class Codes: G01N 35/1002 Reagent dispensers
• CPC Class Codes: Y10T 436/111666 Utilizing a centrifuge or compartmented rotor

Abstract

An analytical rotor which comprises a receptacle for receiving a post on a centrifuge and a sealed rigid container in the rotor body proximate to the receptacle is provided. The seal on the container is opened when the post is inserted in the receptacle, thereby releasing a liquid in the container. The seal is preferably opened through the displacement of the container caused by positioning of the rotor on the centrifuge post.

Claims

1. An analytical rotor for use with a centrifuge, the rotor comprising:

a rotor body having an axis of rotation, a top surface, and a bottom surface;

a receptacle on a surface of the rotor body for receiving a post on the centrifuge;

a container holding a liquid and comprising a seal, wherein the container is movably positioned in a chamber of the body adjacent to the receptacle;

means for engaging and holding a portion of the seal against displacement relative to the chamber such that insertion of the post into the receptacle displaces the container to open the seal and releases the liquid.

2. The rotor of claim 1, wherein the seal comprises a laminated foil seal and the means for engaging and holding a portion of the seal comprises a tab anchored to the rotor, such that the foil seal is peeled from the container in response to the insertion of the post in the receptacle.

3. The rotor of claim 1, wherein the container comprises more than one compartment.

4. The rotor of claim 1 further comprising a piston positioned in the receptacle, which piston shifts the container to an open position.

5. The rotor of claim 1, wherein the liquid is a reagent for the analysis of blood.

6. The rotor of claim 5, wherein the reagent is a diluent.

7. The rotor of claim 1, wherein the receptacle is disposed on the bottom surface of the rotor body.

8. The rotor of claim 7, wherein the receptacle is positioned at the axis of rotation of the rotor body and the post is a spindle on the centrifuge.

9. The rotor of claim 1, further comprising a receiving chamber for receiving the liquid through a channel connecting the container and the receiving chamber.

10. A rotor of claim 9, wherein the receiving chamber is connected by a channel to a separation chamber located radially outward from the receiving chamber, the separation chamber having a cell trap and a means for introducing a biological sample therein.

11. A rotor of claim 9, further comprising a plurality of cuvettes disposed radially outward from the receiving chamber.

12. An analytical rotor for use with a centrifuge, the rotor comprising:

a rotor body having an axis of rotation, a top surface, and a bottom surface;

a receptacle on a surface of the rotor body for receiving a post on the centrifuge;

a container holding a liquid and comprising a rigid side having a scribe mark, wherein the container is movable positioned in a chamber of the body adjacent to the receptacle;

means for engaging and holding a portion of the container against displacement relative to the chamber such that insertion of the post into the receptacle displaces the container, thereby splitting the rigid side along the scribe mark and releasing the liquid.

13. The rotor of claim 12, wherein the rigid side is formed from sheet plastic material.

14. An analytical rotor for use with a centrifuge, the rotor comprising:

a rotor body having a bottom surface;

a receptacle on the bottom surface of the rotor body for receiving a post on the centrifuge;

a sealed container holding a liquid and comprising a seal, wherein the container is movably positioned in a chamber of the body adjacent to the receptacle;

means for engaging and holding a portion of the seal against displacement relative to the chamber such that insertion of the post into the receptacle as the rotor is mounted in the centrifuge displaces the container to thereby open the seal and deliver the liquid through a channel to a receiving chamber as the rotor is spun.

15. The rotor of claim 14, wherein the container comprises more then one compartment.