Examined body interior information observing apparatus by using photo-pulses controlling gains for depths

• US 5,305,759 A
• Filed: 05/14/1991
• Issued: 04/26/1994
• Est. Priority Date: 09/26/1990
• Status: Expired due to Term

• Current Assignee: Olympus Optical Company Ltd. (Olympus Corporation)
• Original Assignee: Olympus Optical Company Ltd. (Olympus Corporation)
• Inventors: Suzuki, Hiromasa, Takahashi, Susumu, Takayam, Shuichi, Kaneko, Mamoru, Nakamura, Kazunari, Gotanda, Masakazu, Nakamura, Ichiro, Kami, Kuniaki, Fuse, Eiichi, Kosaka, Yoshihiro
• Primary Examiner(s): Howell, Kyle L.
• Assistant Examiner(s): ZELE, KRISTA MICHELLE
• Application Number:
  US07/700,225
• Time in Patent Office: 1,078 Days
• Field of Search: 128/633, 128/634, 128/665, 128/395, 128/4, 128/6, 606/2, 606/3, 606/4, 356/317, 356/318, 607/88, 607/89
• US Class Current: 600/476
• CPC Class Codes: A61B 2562/0242 for varying or adjusting the optical path length in the tissue
• CPC Class Codes: A61B 5/0059 using light, e.g. diagnosis by transillumination, diascopy, fluorescence A61B5/0093, A61B5/1455, A61B5/02416 and A61B5/0261 take precedence

Abstract

A photo-pulse from a photo-pulse generating apparatus is branched, where one branch is radiated to an examined body and the reflected light reflected within the examined body is delayed in time in proportion to the depth from the surface of the examined body and is led to a time-analyzing reflected light measuring apparatus. In this measuring apparatus, the other branched reference photo-pulse or reference signal pulse is input as delayed by the time for which the photo-pulse reflected within the examined body returns and only the reflected light component synchronized with the entering timing of this reference light pulse is analyzed in the time and is detected. By varying the detection sensitivity of this measuring apparatus in response to the depth from the surface of the examined body, the interior can be observed.

Claims

1. An examined body interior information observing apparatus comprising:

a photo-pulse generating means for generating light energy in the form of photo-pulses for observing the interior of an examined body;

a time-analytical reflected light detecting means for time-analytically measuring in response to a depth from a surface of the examined body light energy emitted from said photo-pulse generating means and reflected within said examined body to produce an output signal; and

a detection sensitivity varying means for varying detection sensitivity so that a level of at least the output signal of said time-analytical reflected light detecting means may vary in response to said light energy reflected from different depths within said examined body.

2. An examined body interior information observing apparatus according to claim 1 wherein said detection sensitivity varying means inputs into said time-analytical reflected light detecting means a detection sensitivity controlling signal for controlling the detection sensitivity of said time-analytical reflected light detecting means.

3. An examined body interior information observing apparatus according to claim 1 further comprising an objective optical system for radiating/condensing said photo-pulses from said photo-pulse generating means to said examined body and said detection sensitivity varying means varies a focus position of said objection optical system in response to said light energy reflected from the depth of said examined body.

4. An examined body interior information observing apparatus according to claim 1 wherein said time-analytical reflected light detecting means has a beam splitting means for branching said photo-pulses emitted from said photo-pulse generating means into two pluses consisting of a first photo-pulse proceeding to said examined body surface and a second photo-pulse used as a reference, a delaying means for delaying said second photo-pulse branched by said beam splitting means and a photo-mixing means for photo-mixing a reflected light energy of said first photo-pulse reflected on a side of said examined body and returning said second photo-pulse delayed by said delaying means and substantially extracting only a reflected component of said first photo-pulse which is synchronized by said time-analytical reflected light detecting means with an input minute time of said second photo-pulse to produce a photo-mixed output light.

5. An examined body interior information observing apparatus according to claim 4 wherein said time-analytical reflected light detecting means has a photoelectrically converting and amplifying means for outputting the output light of said photo-mixing means as an amplified electric signal.

6. An examined body interior information observing apparatus according to claim 5, wherein said detection sensitivity varying means outputs a detection sensitivity controlling signal for controlling the level of the output signal of said photoelectrically converting and amplifying means in response to the above mentioned depth.

7. An examined body interior information observing apparatus according to claim 5 wherein said detection sensitivity varying means applies to said photoelectrically converting and amplifying means a detection sensitivity controlling signal which exponentially increases the detection sensitivity of said photoelectrically converting and amplifying means with said depth.

8. An examined body interior information observing apparatus according to claim 5 wherein said photoelectrically converting and amplifying means is a photo-multiplier tube and said detection sensitivity varying means applies a controlling signal controlling a photo-multiplying rate of said photo-multiplier tube.

9. An examined body interior information observing apparatus according to claim 5 wherein said photo-mixing means has a neutral density filter arranged in front of said photoelectrically converting and amplifying means and having a transmittivity distributed in a peripheral direction and motor for rotating and driving said neutral density filter in the peripheral direction and said detection sensitivity varying means controls a rotation of said motor in response to said depth.

10. An examined body interior information observing apparatus according to claim 4 wherein said photo-mixing means has a transmitting filter for selectively transmitting a predetermined wavelength range component in the photo-mixed output light.

11. An examined body interior information observing apparatus according to claim 10 wherein said photo-mixing means has a photoelectrically converting and amplifying means outputting as an electric signal said output light passed through said filter.

12. An examined body interior information observing apparatus according to claim 4 wherein said delaying means includes a mirror oriented to be opposed to said beam splitting means for delaying said second photo-pulse from entering a side of said photo-mixing means for a time corresponding to the distance from said beam splitting means to said mirror in said delaying means.

13. An examined body interior information observing apparatus according to claim 12 wherein said delaying means has an adjusting means for varying the distance between said mirror and said beam splitting means.

14. An examined body interior information observing apparatus according to claim 4 wherein said photo-mixing means includes a non-linear optical device having a non-linear input and output characteristic for entering light energy.

15. An examined body interior information observing apparatus according to claim 1 wherein said time-analytical reflected light detecting means has a beam splitting means for branching each said photo-pulse emitted from said photo-pulse generating means into two photo-pulses consisting of a first photo-pulse proceeding to said examined body surface and a second photo-pulse, a delaying means for delaying said second photo-pulse branched by said beam splitting means and a shutter means for selectively extracting a reflected light component of said first photo-pulse synchronized by said time-analytical reflected light detecting means with the timing of a reference signal corresponding to a reflected light of said first photo-pulse reflected from a side of said examined body and said second photo-pulse delayed by said delaying means with said reference signal.

16. An examined body interior information observing apparatus according to claim 15 wherein said time-analytical reflected light extracting means has a streak camera which the light having passed through said shutter means enters.

17. An examined body interior information observing apparatus according to claim 16 wherein detection sensitivity of said streak camera is controlled by said detection sensitivity varying means.

18. An examined body interior information observing apparatus according to claim 15 wherein said shutter means includes an optical shutter and a controlling apparatus controlling said optical shutter, said optical shutter being optically opened and closed by the application of a controlling signal output from said controlling apparatus, said controlling signal corresponding to an input of said reference signal to said controlling apparatus.

19. An examined body interior information observing apparatus according to claim 15 wherein said delaying means includes a photoelectric converting means for photoelectrically converting said second photo-pulse branched by said beam splitting means and an electric delaying device for delaying an output signal of said photoelectric converting means.

20. An examined body interior information observing apparatus according to claim 1 further comprising a scanning means for two-dimensionally scanning said photo-pulses radiated to said examined body.

21. An examined body interior information observing apparatus according to claim 1 further comprising a signal processing means processing the output signal of said time-analytical reflected light detecting means to produce a video signal.

22. An examined body interior information observing apparatus according to claim 21 further comprising a monitor means for displaying said video signal output from said signal processing means.

23. An examined body interior information observing apparatus according to claim 1 wherein said photo-pulse generating means includes a solid state laser emitting a laser light having a short pulse width.

24. An examined body interior information observing apparatus according to claim 1 wherein said photo-pulse generating means includes a solid state laser emitting a laser light having a short pulse width and a dye laser photo-excited by the laser light emitted from said solid state laser for emitting a laser light having a wide wavelength bandwidth.

25. An examined body interior information observing apparatus according to claim 1 further comprising at least one observing optical system for forming an optical image of said examined body.

26. An examined body interior information observing apparatus according to claim 25 further comprising a microscope having two said observing optical systems.

27. An examined body interior information observing apparatus according to claim 25 wherein said at least one observing optical system includes a relay lens system.

28. An examined body interior information observing apparatus according to claim 25 further comprising an illuminating optical system for illuminating said examined body with an illuminating light having a wavelength in a visible range.

29. An examined body interior information observing apparatus according to claim 28, further comprising an elongate insertable section, wherein said observing optical system and said illuminating optical system are provided at a tip of said elongate insertable section.

30. An examined body interior information observing apparatus according to claim 28, further comprising an endoscope wherein said observing optical system and said illuminating optical system are provided at a tip of an elongate insertable section of the endoscope.

31. An examined body interior information observing apparatus according to claim 30 wherein the thickness of said insertable part is small enough to be insertable into a blood vessel.

32. An examined body interior information observing apparatus according to claim 30 wherein said endoscope includes a channel, said photo-pulse generating means includes an elongate light guide for leading said photo-pulses emitted from said photo-pulse generating means, wherein said light guide is inserted through said channel and said photo-pulses radiated to a first end surface of said light guide are emitted to a side of said examined body from a second end surface of said light guide.

33. An examined body interior information observing apparatus according to claim 1 wherein said photo-pulse generating means includes an elongate light guide means for leading said photo-pulses emitted from said photo-pulse generating means to a first end surface of said light guide and emanating said photo-pulse from a second end surface of said light guide to said examined body.

34. An examined body interior information observing apparatus according to claim 33 wherein said light guide is formed of a fiber bundle in which respective optical fibers are cylindrically arranged and the photo-pulses are emitted in a radial direction of said cylinder from said second end surface and said photo-pulse generating means has a scanning means for successively radiating said photo-pulses to said first end surface of each said optical fiber.

35. An examined body interior information observing apparatus according to claim 34 wherein said light guide includes a single fiber bundle and has a driving means for two-dimensionally driving said second end surface of said single fiber bundle and two-dimensionally scanning the radiation position of said photo-pulses radiated to said examined body.

36. An examined body interior information observing apparatus according to claim 35 further comprising a signal processing means for processing the output signal of said time-analytical reflected light detecting means in the respective states driven by said driving means to produce a two-dimensional cross-sectioned image.

37. An examined body interior information observing apparatus according to claim 34 further comprising a signal processing means for processing the output signal of said time-analytical reflected light detecting means in the respective states scanned by said scanning means to produce a two-dimensional cross-sectioned image.

38. An examined body interior information observing apparatus according to claim 1 wherein said photo-pulse generating means includes an expanding means for expanding said photo-pulses emitted from said photo-pulse generating means and an optical fiber bundle transmitting the photo-pulses expanded by said expanding means and entering a first end surface of said fiber bundle, emitting the same to said examined body side from a second end surface of said fiber bundle, receiving on said second end surface the light reflected by said examined body and emitting the same to said time-analytical reflected light detecting means from said first end surface.

39. An examined body interior information observing apparatus according to claim 38 wherein said time-analytical reflected light detecting means includes an imaging device for receiving reflected light emitted through each optical fiber from said first end surface of said fiber bundle and converting the same to an electric signal.

40. An examined body interior information observing apparatus according to claim 39 further comprising a signal processing means for processing said electric signal output from said imaging device to produce a video signal corresponding to a cross-sectioned image of said interior of said examined body.

41. An examined body interior information observing apparatus according to claim 40 further comprising a monitor means for displaying said video signal.

42. An examined body interior information observing apparatus according to claim 39 wherein said time-analytical reflected light detecting means includes a reference pulse generating timing producing means for delaying said photo-pulses for a time corresponding to a light path length in which said photo-pulses emitted from said photo-pulse generating means and reflected at any depth in said examined body return to produce a reference pulse corresponding to said depth and a reflected light extracting means for extracting only a reflected light component substantially synchronized by said time-analytical reflected light detecting means with a time when said reference pulse in the light reflected by said examined body is output.

43. An examined body interior information observing apparatus according to claim 42 wherein said reference pulse generating timing producing means includes a signal processing means for processing said electric signal output from said imaging device when a output timing of said reference pulse is varied to produce a video signal corresponding to a three-dimensional cross-sectioned image.

44. An examined body interior information observing apparatus according to claims 38 or 39 further comprising a photo-shutter for controlling the passage/interception of the reflected light emitted from said first end surface of said optical fiber bundle.

45. An examined body interior information observing apparatus according to claim 38 wherein said time-analytical reflected light detecting means has a reference pulse generating timing producing means for delaying said photo-pulses for a time corresponding to a light path length in which said photo-pulses emitted from said photo-pulse generating means and reflected at any depth in said examined body return to produce a reference pulse corresponding to said depth and a reflected light extracting means for extracting only a reflected light component substantially synchronized by said time-analytical reflected light detecting means with a time when said reference pulse in the light reflected by said examined body is output.

46. An examined body interior information observing apparatus according to claim 1 further comprising a light transmitting means for radiating to said examined body said photo-pulses emitted from said photo-pulse generating means, and for leading light energy reflected by said examined body to said time-analytical reflected light detecting means, wherein said light transmitting means comprises an optical system divided into a means for memorizing only a reflected information signal corresponding to the reflected light energy reaching a surface of said optical system detected by said time-analytical reflected light detecting means, and an operating means for removing the reflected information signal memorized by said memorizing means from all information signals corresponding to all reflected light energy, including the light energy from said light transmitting means detected by said time-analytical reflected light detecting means and the returning light energy from an observed part of said examined body and producing the reflected information signal corresponding to a reflected light energy component actually reflected by said examined body.

47. An examined body interior information observing apparatus according to claim 1 wherein said photo-pulse generating means includes a solid state laser emitting a laser light having a short pulse width and a titanium sapphire laser photo-excited by the laser light emitted from said solid state laser for emitting a laser light having a wide wavelength bandwidth.

48. An examined body interior information observing apparatus comprising:

a photo-pulse generating means for generating light energy in the form of photo-pulses for observing the interior of an examined body;

a detecting timing setting means for delaying said photo-pulses generated by said photo-pulse generating means and producing a reference signal;

a time-analytical reflected light energy detecting means for time-analytically detecting the light energy reflected within said examined body; and

a detection sensitivity/detecting level varying means for varying a detection sensitivity/detecting level so that a level of at least an output signal of said time-analytical reflected light energy detecting means may vary.

49. An examined body interior information observing apparatus according to claim 48 wherein said detecting sensitivity/detecting level varying means includes means for variably-controlling said photo-pulse generating means.

50. An examined body interior information observing apparatus according to claim 48 wherein said detection sensitivity/detecting level varying means inputs into said time-analytical reflected light detecting means a detection sensitivity controlling signal for controlling a detection sensitivity of said time-analytical reflected light detecting means.