Method of treating body passage walls

• US 5,306,249 A
• Filed: 04/19/1992
• Issued: 04/26/1994
• Est. Priority Date: 01/12/1990
• Status: Expired due to Term

• Current Assignee: Don Michael International, LLC
• Original Assignee: T. Anthony Don Michel
• Inventors: Don Michel, T. Anthony
• Primary Examiner(s): Rosenbaum, C. Fred
• Assistant Examiner(s): SMITH, CHALIN A
• Application Number:
  US07/868,961
• Time in Patent Office: 737 Days
• Field of Search: 604/96-101, 604/49, 128/632, 128/898, 606/191, 606/192, 606/194
• US Class Current: 604/101.05
• CPC Class Codes: A61B 2017/22084 stone- or thrombus-dissolving
• CPC Class Codes: A61M 2025/0057 Catheters delivering medicament other than through a conventional lumen, e.g. porous walls or hydrogel coatings
• CPC Class Codes: A61M 2025/1052 for temporarily occluding a vessel for isolating a sector
• CPC Class Codes: A61M 2025/1061 having separate inflations tubes, e.g. coaxial tubes or tubes otherwise arranged apart from the catheter tube
• CPC Class Codes: A61M 2025/1095 with perfusion means for enabling blood circulation while the balloon is in an inflated state or in a deflated state, e.g. permanent by-pass within catheter shaft
• CPC Class Codes: A61M 2025/1097 with perfusion means for enabling blood circulation only while the balloon is in an inflated state, e.g. temporary by-pass within balloon
• CPC Class Codes: A61M 25/0021 characterised by the form of the tubing A61M25/0054 takes precedence
• CPC Class Codes: A61M 25/0032 characterized by at least one unconventionally shaped lumen, e.g. polygons, ellipsoids, wedges or shapes comprising concave and convex parts
• CPC Class Codes: A61M 25/007 Side holes, e.g. their profiles or arrangements; Provisions to keep side holes unblocked
• CPC Class Codes: A61M 25/0155 with hydraulic or pneumatic means, e.g. balloons or inflatable compartments
• CPC Class Codes: A61M 25/1011 Multiple balloon catheters

Abstract

A method for performing a therapeutic treatment on a section of a wall of a body passage, by: isolating a portion of the body passage which encloses the section from the remainder of the body passage; introducing into the isolated portion of the body passage a liquid medium containing a treatment agent; maintaining the treatment agent in the isolated portion for a predetermined time period; during the step of maintaining, periodically withdrawing a sample of the liquid medium from the isolated portion of the body passage, analyzing the sample to determine the proportion of treatment agent present in the liquid medium in the isolated portion and modifying the liquid medium in the isolated portion to establish a desired proportion of the treatment agent in the liquid medium in the isolated portion.

Claims

1. A method for performing a therapeutic treatment on a section of a wall of a body passage, comprising:

isolating a portion of the body passage which encloses the section from the remainder of the body passage;

introducing into the isolated portion of the body passage a liquid medium containing a treatment agent;

maintaining the treatment agent in the isolated portion for a predetermined time period;

during said step of maintaining, periodically withdrawing a sample of the liquid medium from the isolated portion of the body passage, analyzing the sample to determine the proportion of treatment agent present in the liquid medium in the isolated portion and modifying the liquid medium in the isolated portion on the basis of the analysis to establish a desired proportion of the treatment agent in the liquid medium in the isolated portion.

2. A method as defined in claim 1 wherein the body passage is a blood vessel.

3. A method as defined in claim 2 wherein the liquid medium comprises blood.

4. A method as defined in claim 3 wherein the treatment agent comprises genetically altered cells.

5. A method as defined in claim 3 wherein said step of modifying comprises adding a quantity of treatment agent determined by the result of said analyzing step.

6. A method as defined in claim 2 wherein the predetermined time period is 30-60 minutes.

7. A method as defined in claim 1 wherein the liquid medium comprises a saline solution.