Absorbable stent

• US 5,306,286 A
• Filed: 02/01/1991
• Issued: 04/26/1994
• Est. Priority Date: 06/25/1987
• Status: Expired due to Term

• Current Assignee: Duke University
• Original Assignee: Duke University
• Inventors: Klopovic, Zenaida P., Stack, Richard S.
• Primary Examiner(s): Thaler, Michael H.
• Application Number:
  US07/649,534
• Time in Patent Office: 1,180 Days
• Field of Search: 623/1, 606/151-153, 606/154-156, 606/191, 606/198, 606/108
• US Class Current: 623/1.12
• CPC Class Codes: A61F 2/92 Stents in the form of a rolled-up sheet expanding after insertion into the vessel , e.g. with a spiral shape in cross-section
• CPC Class Codes: A61F 2/958 Inflatable balloons for placing stents or stent-grafts
• CPC Class Codes: A61F 2210/0004 bioabsorbable
• CPC Class Codes: A61F 2230/0076 ellipsoidal or ovoid
• CPC Class Codes: A61L 31/148 Materials at least partially resorbable by the body

Abstract

An absorbable stent for placement at the locus of a stenotic lesion which is flexible and compliance for safe and effective delivery to the cite of a coronary obstruction, for example, and so as to avoid arterial rupture or aneurysm formation while under continuous stress of a beating heart. The stent is expandable from a reduced diameter configuration, which facilitates delivery to the cite of a targeted arterial obstruction, to an expanded configuration when disposed within the targeted area. The stent can be carried to the cite to be treated and expanded to its supporting diameter on any suitable expandable catheter such as a mechanically expandable catheter or a catheter having an inflatable balloon. The stent is formed so as to have a wall with pores and/or holes to facilitate tissue ingrowth and encapsulation of the stent. The stent will subsequently be bioabsorbed to minimize the likelihood of embolization of the dissolved material.

Claims

1. A stent comprising:

a main body portion having a first open end and a second open end and a lumen extending therethrough, said main body portion being sized for intraluminal placement within a body passage, said main body portion comprising a sheet of material which has first and second free longitudinal edges and which has been rolled into a substantially cylindrical configuration, said material having at least one of holes and pores defined therethrough for tissue ingrowth;

said main body portion being expandable from a first, reduced diameter wherein said free edges at least partially overlap which allows intraluminal transport to a targeted portion of said body passage, to a second expanded diameter at said targeted portion so as to engage and support the interior wall of the body passage in which it is disposed against collapse and stenosis.

2. A stent as in claim 1, in combination with a catheter assembly having a first end adapted to remain exterior to the body passage and a second end adapted to be inserted into the body passage, said second end having an expandable end portion for carrying said main body portion into the targeted portion of the body passage and for expanding said main body portion from said first reduced diameter to said second expanded diameter within the targeted portion of the body passage.

3. The combination of claim 2, further comprising means for mechanically expanding said catheter assembly second end by rotation of a knob provided on said catheter assembly first end.

4. The combination of claim 2, wherein said catheter assembly second end includes an inflatable balloon so as to provide said expandable end portion, whereby the main body portion can be expanded by inflating the balloon.

5. A stent as in claim 1, wherein one longitudinal edge of said sheet includes a means for receiving a second longitudinal end of said sheet so as to facilitate rolling of the sheet of material and maintaining same at a predetermined diameter prior to expansion thereof.

6. A stent as in claim 5, in combination with a catheter assembly having a first end adapted to remain exterior to the body passage and a second end adapted to be inserted into the targeted portion of the body passage, said second end having an expandable end portion for carrying said main body portion into the targeted portion of the body passage and for expanding said main body portion from said first reduced diameter to said second expanded diameter within the targeted portion of the body passage.

7. The combination of claim 6, further comprising means for mechanically expanding said catheter assembly second end by rotation of a knob provided on said catheter assembly first end.

8. The combination of claim 6, wherein said catheter assembly second end includes an inflatable balloon so as to provide said expansible end portion, whereby the main body portion can be expanded by inflating the balloon.

9. A stent as in claim 1, wherein said main body portion comprises a sheet of bioabsorbable material.

10. A method of preventing occlusion and stenosis of a body passage comprising:

providing a catheter assembly having an expandable distal end portion;

mounting an expandable stent on said expandable distal end portion of said catheter assembly, said stent including a main body portion having a first open end and a second open end and a lumen extending therethrough, said main body portion being sized for intraluminal placement within a targeted portion of a body passage, said main body portion comprising a sheet of material which has first and second free longitudinal edges and which has been rolled into a substantially cylindrical configuration, said material having at least one of holes and pores defined therethrough for tissue ingrowth;

said main body portion being expandable from a first reduced diameter wherein said free edges at least partially overlap and which allows transluminal transport to a stenotic portion of a targeted portion of a body passage, to a second expanded diameter at said targeted portion to engage and support the interior wall of the body passage in which it is disposed against collapse and stenosis;

inserting said catheter assembly distal end into a body passage;

guiding said distal end to a targeted portion of the body passage; and

expanding said expandable portion to expand said stent so as to engage, expand, and support the interior walls of the targeted portion of the body passage.

11. A method as in claim 10, wherein said step of providing a catheter assembly comprises providing a catheter assembly having an inflatable balloon on the distal end thereof.

12. A method as in claim 10, wherein said step of providing a catheter assembly comprises providing a catheter assembly having a mechanically expandable distal end portion.

13. A method as in claim 10, wherein said step of mounting an expandable stent comprises mounting an expandable stent having a main body portion comprising a sheet of bioabsorbable material.

14. A method as in claim 10, further comprising the steps of:

reducing the diameter of said distal end portion so as to leave said stent an engagement with and supporting the body passage; and

removing the distal end portion of the catheter assembly from the body passage.

15. A method as in claim 10, wherein one longitudinal edge of said sheet includes means for receiving a second longitudinal end of said sheet so as to facilitate rolling of the sheet of material and maintaining the same at a predetermined diameter prior to expansion thereof.