Pharmaceutical composition for rapid suspension in water
First Claim
1. A solid pharmaceutical composition for addition to water to produce a suspension of a drug comprising a mixture ofa) a drug which is substantially water-insoluble or microencapsulated;
- with granules comprising an inert carrier coated with an intimate mixture consisting essentially ofb) a thickening or suspending agent;
c) a pharmaceutically accepted acid;
d) a pharmaceutically acceptable carbonate or bicarbonate;
characterized in that the weight ratio of c+d;
b is from 1;
1.5 to 1;
15 and the amount of c+d is sufficient to obtain rapid hydration of the thickening or suspending agent b) when the composition is mixed with water such that a homogeneous suspension of the drug is obtained within 30 seconds.
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Abstract
The invention provides a solid pharmaceutical composition for addition to water to produce a suspension of a drug comprising (a) a drug which is substantially water-insoluble or microencapsulated; (b) a thickening or suspending agent; (c) a pharmaceutically acceptable acid; (d) a pharmaceutically acceptable carbonate or bicarbonate; characterised in that the weight ratio of c+d:b is from 1:1.5 to 1:15 and the amount of c+d is sufficient to obtain rapid hydration of the thickening or suspending agent (b) when the composition is mixed with water such that a homogeneous suspension of the drug is obtained within 30 seconds. A method for preparing the composition is also described.
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Citations
19 Claims
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1. A solid pharmaceutical composition for addition to water to produce a suspension of a drug comprising a mixture of
a) a drug which is substantially water-insoluble or microencapsulated; - with granules comprising an inert carrier coated with an intimate mixture consisting essentially of
b) a thickening or suspending agent; c) a pharmaceutically accepted acid; d) a pharmaceutically acceptable carbonate or bicarbonate;
characterized in that the weight ratio of c+d;
b is from 1;
1.5 to 1;
15 and the amount of c+d is sufficient to obtain rapid hydration of the thickening or suspending agent b) when the composition is mixed with water such that a homogeneous suspension of the drug is obtained within 30 seconds. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
- with granules comprising an inert carrier coated with an intimate mixture consisting essentially of
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13. A method for preparing a pharmaceutical composition which method comprises mixing granules comprising an inert carrier coated with an intimate mixture of b) a thickening or suspending agent, c) a pharmaceutically acceptable acid, d) a pharmaceutically acceptable base selected from the group consisting of carbonates and bicarbonates with a) a water insoluble or microencapsulated drug;
- wherein the ratio of c+d;
b is from 1;
1.5 to 1;
15 and the amount of c+d is sufficient to obtain rapid hydration of the thickening or suspending agent b) when the composition is mixed with water such that a homogeneous suspension of the drug is obtained within 30 seconds. - View Dependent Claims (14, 15, 16, 17, 18, 19)
- wherein the ratio of c+d;
Specification