Heat surgery system monitored by real-time magnetic resonance profiling

• US 5,307,812 A
• Filed: 03/26/1993
• Issued: 05/03/1994
• Est. Priority Date: 03/26/1993
• Status: Expired due to Term

• Current Assignee: InSightec Ltd.
• Original Assignee: General Electric Company
• Inventors: Hardy, Christopher J., Cline, Harvey E.
• Primary Examiner(s): Smith, Ruth S.
• Application Number:
  US08/038,204
• Time in Patent Office: 403 Days
• Field of Search: 128/653.2, 128/736, 128/24 AA, 128/653.5, 128/804, 607/88, 607/89, 607/96, 607/97, 324/315, 324/309, 606/2, 606/3, 606/11, 606/14-16
• US Class Current: 600/411
• CPC Class Codes: A61B 18/24 with a catheter A61B18/26, A61B18/28 take precedence
• CPC Class Codes: A61B 2090/374 NMR or MRI
• CPC Class Codes: A61N 7/02 Localised ultrasound hyperthermia hyperthermia in general A61F7/00
• CPC Class Codes: G01R 33/4804 Spatially selective measurement of temperature or pH
• CPC Class Codes: G01R 33/561 by reduction of the scanning time, i.e. fast acquiring systems, e.g. using echo-planar pulse sequences
• CPC Class Codes: G01R 33/56308 Characterization of motion or flow; Dynamic imaging

Abstract

Surgery is performed with a pulsed heat-producing device that selectively heats a region in a specific tissue within a patient destroying the tissue. The pulsed heat-producing device may be a coherent optical source that is guided by laser fiber to the tissue to be destroyed. In another embodiment, the pulsed heat-producing device is a focussed ultrasound transducer which concentrates ultrasonic energy at a focal point within the specific tissue. A magnetic resonance imaging system employing a real-time temperature-sensitive pulse sequence monitors the heated region of the tissue to provide temperature profiles allowing an operator to alter the position and size of the heated region.

Claims

1. A magnetic resonance (MR) pulsed heat system for allowing an operator to selectively heat tissue within a patient comprising:

a) pulsed heat-producing means adapted for concentrating energy at an application point;

b) positioning means for positioning the application point of the pulsed heat-producing means in a specific tissue within the patient so as to create a heated region within the specified tissue;

c) operator responsive control means for enabling said operator to control the positioning means;

d) an MR imaging means comprising;

1. a radiofrequency (RF) transmitter for transmitting an RF sine(x)/x "sinc" selection pulse and a 180°

RF sinc refocussing pulse into said patient;

2. a gradient means for

i. creating a slice selection magnetic field gradient along an "X" direction simultaneously with application of the RF sinc selection pulse to cause excitation of a first slice of tissue within said patient,

ii. applying a first set of diffusion gradients in the "X" direction, and in the "Y" and "Z" directions orthogonal to the "X" direction after selection of the first slice and before application of the 180°

RF sinc refocussing pulse to cause a phase evolution of a plurality of nuclear spins in said patient;

iii. creating a second slice selection magnetic field gradient simultaneously with application of the 180°

RF sinc refocussing pulse to cause phase reversal only within a second slice of tissue within said patient intersecting the first slice, thereby creating a rod-shaped region of excited nuclear spins with reversed phase,

iv. applying a second set of diffusion gradients in the "X", "Y" and "Z" directions after application of the 180°

RF since refocussing pulse to cause a second phase evolution of the nuclear spins, thereby encoding diffusion of the nuclear spins in the excitation region, and

v. applying a readout gradient to said rod-shaped excitation region along the length of the excitation region being the "Z" direction for which a temperature-sensitive profile desired;

3. receiver means for receiving an MR response signal from the rod-shaped excitation region; and

4. computation means for computing a temperature vs. position profile along the readout gradient from the MR response signal received from the receiver means, thereby creating real-time temperature-sensitive MR images of the heated region; and

e) display means for displaying the temperature-sensitive images to said operator.

2. The MR pulsed heat system system of claim 1 wherein the pulsed heat-producing means comprises:

a) a source of pulsed optical energy;

b) an invasive device adapted for insertion into the patient to reach the specific tissue of the patient; and

c) an optical fiber having an external end and an internal end adapted to be fitted into the invasive device with its internal end within the specific tissue, the fiber being adapted to pass the optical energy from the pulsed optical energy source into the external end, to its application point in the specific tissue adjacent the internal end.

3. The MR pulsed heat system system of claim 2 wherein the source of pulsed optical energy comprises a laser.

4. The MR pulsed heat system system of claim 1 wherein the pulsed heat-producing means comprises:

an ultrasonic transducer adapted to generating pulsed ultrasonic energy concentrated at a focal point, the focal point being the application point.

5. The method of performing heat surgery on a patient as guided by magnetic resonance (MR) imaging comprising, the steps of:

a) creating an internal image of tissues of said patient;

b) determining the position of a specified tissue in the patient;

c) applying pulsed heat at a predetermined pulse frequency to the specified tissue to create a heated region within the specified tissue;

d) monitoring the heated region with an MR imaging means by;

1. transmitting an RF sine(x)/x "sinc" selection pulse into said patient;

2. applying a slice selection magnetic field gradient along an "X" direction simultaneously with application of the RF sinc selection pulse to cause excitation of a first slice of tissue within said patient;

3. applying a first set of diffusion gradients in the "X" direction, and a "Y" and "Z" direction orthogonal to the "X" direction to cause a phase evolution of a plurality of nuclear spins in the first slice of said patient;

4. transmitting a 180°

RF sinc refocussing pulse into said patient reversing the phase of the nuclear spins;

5. applying a second slice selection magnetic field gradient simultaneously with the application of the 180°

RF sinc refocussing pulse causing excitation of a second slice of tissue within said patient intersecting the first slice and thereby create a rod-shaped excitation region;

6. applying a second set of diffusion gradients in the "X", "Y" and "Z" directions after application of the 180°

RF sinc refocussing pulse to cause a second phase evolution of the nuclear spins and thereby encode diffusion of the nuclear spins;

7. applying a readout gradient to the rod-shaped excitation region along the length of the excitation region, the rod-shaped excitation region being along the "Z" direction for which a temperature-sensitive profile is desired;

7. The method of performing heat surgery on a patient of claim 5 wherein the step of applying pulsed heat comprises the steps of:

a) focussing ultrasonic waves on an application point; and

b) positioning the application point at a predetermined location within the specific tissue.

8. The method of performing heat surgery on a patient of claim 5 wherein the step of applying pulsed heat comprises the steps of:

a) creating optical energy; and

b) passing the optical energy through an optical fiber to a predetermined application point within the specific tissue.

6. receiving an MR response signal from the rod-shaped excitation region;

and

9. computing a temperature vs. position profile along the readout gradient from the MR response signal; and

e) adjusting the frequency and the position of the heated region so as to heat the specified tissue without substantial injury to adjacent tissue.