Multiple dose injection pen

• US 5,308,340 A
• Filed: 06/17/1993
• Issued: 05/03/1994
• Est. Priority Date: 06/05/1989
• Status: Expired due to Term

• Current Assignee: Eli Lilly and Company
• Original Assignee: Eli Lilly and Company
• Inventors: Harris, Dale C.
• Primary Examiner(s): Yasko, John D.
• Assistant Examiner(s): Maglione, Corrine
• Application Number:
  US08/079,307
• Time in Patent Office: 320 Days
• Field of Search: 604/192, 604/193, 604/201, 604/203, 604/207-211, 604/218, 604/224, 604/246
• US Class Current: 604/208
• CPC Class Codes: A61J 1/1406 Septums, pierceable membranes
• CPC Class Codes: A61M 2005/3154 limiting maximum permissible dose
• CPC Class Codes: A61M 2205/581 by audible feedback
• CPC Class Codes: A61M 2205/582 by tactile feedback
• CPC Class Codes: A61M 5/315 Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
• CPC Class Codes: A61M 5/31505 Integral with the syringe barrel, i.e. connected to the barrel so as to make up a single complete piece or unit
• CPC Class Codes: A61M 5/31525 Dosing burettes, pipettes B01L3/02
• CPC Class Codes: A61M 5/31535 Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
• CPC Class Codes: A61M 5/31548 Mechanically operated dose setting member
• CPC Class Codes: A61M 5/31551 including axial movement of dose setting member
• CPC Class Codes: A61M 5/31561 using freely adjustable volume steps
• CPC Class Codes: A61M 5/31563 interacting with a displaceable stop member
• CPC Class Codes: A61M 5/3158 performed by axially moving actuator operated by user, e.g. an injection button
• CPC Class Codes: A61M 5/31591 Single dose, i.e. individually set dose administered only once from the same medicament reservoir, e.g. including single stroke limiting means
• CPC Class Codes: A61M 5/50 having means for preventing re-use, or for indicating if defective, used, tampered with or unsterile retractable needles or needle protectors with means for preventing re-use A61M5/321

Abstract

The present invention relates to a hypodermic syringe having the same general appearance as a pen which is specifically adapted to provide for multiple measure injections of materials such as insulin or human growth hormone.

Claims

1. An improved means for adjustment of the dosage of liquid to be injected from a syringe having a housing for receiving a container of liquid, the container of liquid having a closed first end and a piston closing a second end of the container, the housing having a proximal end and a distal end, the distal end being adapted to receive an injection needle assembly for permitting liquid to pass out of the container first end, a plunger rod, having a non-cylindrical cross-section with a first surface, including threads, and a second surface, received within the housing for exerting a force on the piston closing the container second end, the improvement comprising:

first means received within the housing adjacent the container second end for preventing rotation of the plunger rod in relation to the housing;

second means engaging a second surface of the plunger road for restricting movement of the plunger rod toward the housing proximal end,

third means used to adjust the dosage of liquid to be injected from the syringe, which means rotatably engages a first surface of the plunger road for calibrated axial movement with respect to the plunger rod and housing toward the housing proximal end,

fourth means fixed with respect to the housing for stopping any movement of the third means toward the housing distal end at a fixed position relative to the housing, and

limit means for limiting the maximum calibrated movement of the third means.

2. The improvement of claim 1 wherein the first means comprises a collar received within the housing adjacent the container second end, the collar having a non-cylindrical opening corresponding generally to the cross-section of the plunger rod for preventing rotation of the plunger rod with respect to the housing.

3. The improvement of claim 2 wherein the collar comprises a radial outside surface frictionally engaging an inside surface of the housing, and a distal end surface contacting the container of liquid for maintaining the container in fixed position with respect to the housing.

4. The improvement of claim 2 wherein the second means comprises engaging means included within the collar non-cylindrical opening and engaging a second surface on the plunger rod for restricting movement of the plunger rod toward the housing proximal end.

5. The improvement of claim 1 wherein the second means comprises engaging means engaging a second surface on the plunger rod for restricting movement of the plunger rod toward the housing proximal end.

6. The improvement of claim 5 wherein the engaging means comprises a pair of opposed edges situated on opposite sides of the plunger rod each engaging a surface on the plunger rod so as to prevent movement of the plunger rod toward the housing proximal end.

7. The improvement of claim 1 wherein the third means comprises a hollow cap enveloping the plunger rod end opposite the container and extending outward from the housing proximal end, the cap having a threaded interior surface movably engaging the first threaded surface of the plunger rod for calibrated adjustment relative thereto.

8. The improvement of claim 7 wherein the hollow cap further comprises a flexible member projecting outward from the cap and the housing further comprises a grooved interior surface, said flexible member engaging said grooved interior surface of the housing such that the calibrated relative adjustment causes sensible movement of the flexible member.

9. The improvement of claim 7 wherein the limit means comprises a threaded portion on an outer surface of the hollow cap and a follower adjustibly positioned on the threaded outer surface portion of the cap.

10. The improvement of claim 9 wherein the limit means further comprises a barrier element fixed with respect to the housing for limiting the length of movement of the hollow cap relative to the housing by contacting the adjustibly positioned follower.

11. The improvement of claim 1 wherein the third means comprises a hollow cap enveloping the plunger rod end opposite the container and extending outward from the housing proximal end, the cap engaging the plunger rod and having a distal end facing surface for contacting a stop fixed with respect to the housing upon movement of the cap and plunger rod toward the housing distal end.

12. The improvement of claim 11 wherein the distal end facing surface comprises the distal end of the cap, and the stop comprises a land within the housing situated to contact the distal end of the cap so that a proximal portion of the cap remains projecting from the proximal end of the housing.

13. A syringe having means for adjustment for the dosage of liquid to be injected comprising:

a housing for receiving a container of liquid, the container of liquid having a close first end and a piston closing a second end of the container, the housing having a proximal end and a distal end, the distal end being adapted to receive a needle assembly for permitting liquid to pass out of the closed first end of the container,

a plunger rod received within the housing for exerting a force on the piston closing the second of the container, the plunger rod having non-cylindrical cross-section, a first surface including threads, and a second surface,

a collar received within the housing adjacent the container second end, the collar having a non-cylindrical opening corresponding generally to the cross-section of the plunger rod for preventing rotation of the plunger rod with respect to the housing and engaging means engaging the plunger rod second surface for restricting movement of the plunger rod toward the housing proximal end,

a hollow cap enveloping the plunger rod end opposite the container and extending outward from the housing proximal end, the cap having a threaded interior surface rotatably engaging the plunger rod first surface portion for calibrated axial adjustment relative thereto and a distal end facing surface for contacting a stop fixed with respect to the housing upon movement of the cap and plunger rod toward the housing distal end, and

a limit means for limiting the maximum calibrated movement of the hollow cap, used to adjust the dosage of liquid to be injected from the syringe.

14. The syringe of claim 13 wherein the collar comprises a radial outside surface frictionally engaging an inside surface of the housing, and distal end surface contacting the container of liquid for maintaining the container in fixed position with respect to the housing.

15. The syringe of claim 14 wherein the engaging means comprises a pair of opposed edges situated on opposite sides of the plunger road so as to prevent movement of the plunger rod toward the housing proximal end.

16. The improvement of claim 15 wherein the hollow cap further comprises a flexible member projecting outward from the cap and the housing further comprises a grooved interior surface, said flexible member engaging said grooved interior surface of the housing such that the calibrated relative adjustment causes sensible movement of the flexible member.

17. The syringe of claim 16 wherein the distal end facing surface comprises the distal end of the cap, and the stop comprises a land within the housing situated to contact the distal end of the cap so that a proximal portion of the cap remains projecting from the proximal end of the housing.

18. The improvement of claim 17 wherein the limit means comprises a threaded portion on an outer surface of the hollow cap and a follower adjustibly positioned on the threaded outer surface portion of the cap.

19. The improvement of claim 18 wherein the limit means further comprises a barrier element fixed with respect to the housing for limiting the length of movement of the hollow cap relative to the housing by contacting the adjustibly positioned follower.

20. The syringe of claim 19 further comprising a needle assembly coupled to the distal end of the housing and a safety shield enveloping the needle assembly.

21. The syringe of claim 20 further comprising a covering element enclosing the distal end of the housing and the safety shield, the covering element including a clip member extending along one side of the housing and cooperating therewith.

22. In a syringe having a housing for receiving a container of liquid, the housing having a proximal end and a distal end, the distal end being adapted to receive an injection needle assembly for permitting liquid to pass out of the closed first end of the container, an improved means for adjustment of the dosage of liquid to be injected comprising:

a plunger rod received within the housing for exerting a force on the piston closing the second of the container, the plunger rod having non-cylindrical cross-section, a first surface including threads, and a second surface,

a collar received within the housing adjacent the container second end, the collar having a non-cylindrical opening corresponding generally to the cross-section of the plunger rod for preventing rotation of the plunger rod with respect to the housing and engaging means engaging the plunger rod second surface for restricting movement of the plunger rod toward the housing proximal end,

a hollow cap enveloping the plunger rod end opposite the container and extending outward from the housing proximal end, the cap having a threaded interior surface rotatably engaging the plunger rod first surface portion for calibrated axial adjustment relative thereto and a distal end facing surface for contacting a stop fixed with respect to the housing upon movement of the cap and plunger rod toward the housing distal end, and

threaded portion on an outer surface of the hollow cap and a follower adjustibly positioned on the threaded outer surface portion of the cap to permit variation in the limit of the calibrated movement of the cap with respect to the plunger rod.

23. The improvement of claim 22 further comprising a barrier element fixed with respect to the housing for limiting the length of movement of the hollow cap relative to the housing by contacting the adjustibly positioned follower.

24. The improvement of claim 22 wherein the distal end facing surface comprises the distal end of the cap, and the stop comprises a land within the housing situated to contact the distal end of the cap so that a proximal portion of the cap remains projecting from the proximal end of the housing.

25. The improvement of claim 22 wherein the hollow cap further comprises a flexible member projecting outward from the cap and the housing further comprises a grooved interior surface, said flexible member engaging said grooved interior surface of the housing, the calibrated relative adjustment causing sensible movement of the flexible member.

26. The improvement of claim 22 wherein the engagement means comprises a pair of opposed pawls situated on opposite side of the plunger rod and the plunger rod further comprises a line of ratchet teeth on its second surface, said opposing pawls each engaging a line of ratchet teeth so as to prevent movement of the plunger rod toward the housing proximal end.

27. The improvement of claim 22 wherein the collar comprises a radial outside surface frictionally engaging an inside surface of the housing, and a distal end surface contacting the container of liquid for maintaining the container in fixed position with respect to the housing.

28. The improvement of claim 22 further comprising a scale on an outer surface of the cap for indicating a dose to be delivered by the syringe, the scale having a first end situated substantially at the housing proximal end when said distal end facing surface contacts said stop.

29. The improvement of claim 28 wherein the scale includes a stepped line spiralling from said first end toward the distal end of the cap, and indicia associated with at least selected steps of the line for indicating the dose to be delivered.