Ultrasonic bone-therapy and assessment apparatus and method

• US 5,309,898 A
• Filed: 10/13/1993
• Issued: 05/10/1994
• Est. Priority Date: 07/30/1992
• Status: Expired due to Term

• Current Assignee: DJO LLC (Enovis Corp.)
• Original Assignee: Alessandro E. Chiabrera, Jonathan J. Kaufman
• Inventors: Kaufman, Jonathan J., Chiabrera, Alessandro E.
• Primary Examiner(s): Jaworski, Francis
• Application Number:
  US08/136,571
• Time in Patent Office: 209 Days
• Field of Search: 128/24 AA, 128/660.01, 128/660.02, 128/660.03, 128/661.03, 73/597, 73/599
• US Class Current: 601/2
• CPC Class Codes: A61B 8/0875 for diagnosis of bone A61B5/4504 takes precedence
• CPC Class Codes: A61J 7/0481 working on a schedule basis
• CPC Class Codes: A61M 15/00 Inhalators drug delivery in endotracheal tubes A61M16/04
• CPC Class Codes: A61M 15/008 Electronic counters
• CPC Class Codes: A61M 15/009 using medicine packages with incorporated spraying means, e.g. aerosol cans pocket atomiser of the injector type A61M11/08
• CPC Class Codes: A61M 2016/0039 in the inspiratory circuit
• CPC Class Codes: A61M 2016/0042 in the expiratory circuit
• CPC Class Codes: A61M 2205/35 Communication
• CPC Class Codes: A61M 2205/3561 local, e.g. within room or hospital
• CPC Class Codes: A61M 2205/52 with memories providing a history of measured variating parameters of apparatus or patient
• CPC Class Codes: A61N 7/00 Ultrasound therapy lithotripsy A61B17/22, A61B17/225; massage using supersonic vibration A61H23/00 ; using ultrasound for introducing media into the body A61M37/0092
• CPC Class Codes: G01N 2291/02483 Other human or animal parts, e.g. bones
• CPC Class Codes: G01N 29/30 Arrangements for calibrating or comparing, e.g. with standard objects
• CPC Class Codes: G01N 29/348 with frequency characteristics, e.g. single frequency signals, chirp signals measuring frequency of mechanical vibrations or acoustic waves in general G01H1/06, G01H3/04; measuring frequency or analysing frequency spectra G01R23/00
• CPC Class Codes: G01N 29/449 Statistical methods not provided for in G01N29/4409, e.g. averaging, smoothing and interpolation
• CPC Class Codes: Y10S 128/925 Neural network

Abstract

Non-invasive therapeutic treatment and/or quantitative evaluation of bone tissue are performed in vivo, by subjecting bone to an ultrasonic acoustic signal pulse of finite duration, and involving a composite sine-wave signal consisting of plural discrete frequencies that are spaced in the ultrasonic region to approximately 2 MHz; the excitation signal is repeated substantially in the range 1 to 1000 Hz.

In a quantitative evaluation, the composite sine-wave signal is supplied to one of two transducers on opposite sides of the bone, and the signal received by the other transducer is processed (a) to sequentially average the most recently received given number of successive signals to obtain an averaged per-pulse signal and (b) to produce a Fourier transform of the averaged per-pulse bone-transmitted signal. In a separate operation not involving the bone, the same transducers are subjected to the same excitation, reception and processing, wherein the transducers are exposed to a medium of known acoustic properties and path length, all to the end of producing a reference Fourier transform which is processed with the Fourier transform of the bone-transmitted signal, to yield an evaluation or measurement.

In a therapeutic treatment, the transducer supplied by the composite sine-wave signal is thus supplied for a period or periods of time, and with a magnitude, as may be prescribed by the physician for a given patient.

Claims

1. The method of non-invasively therapeutically treating bone tissue in vivo, using an ultrasonic transducer that is non-invasively adapted for acoustic coupling to nearby skin and for transmission through a bony part of a living body, which method comprises the steps of:

(a) acoustically coupling said transducer to nearby skin in a direction toward said bony part;

(b) driving said transducer with a finite-duration composite sine-wave excitation signal meeting the requirements of the following relationship;

##EQU10## where a_i and φ

_i are the amplitude and phase, respectively, associated with frequency f_i, i=1, . . . ,N, and T is chosen to be at least two times longer than the period of the lowest frequency f_i ;

where said composite sine-wave signal consists of plural discrete frequencies that are spaced in the ultrasonic spectral region to approximately 2 MHz and repeating said excitation signal at a rate in the range 1 to 1000 Hz; and

where the amplitudes a_i are chosen according to the relationship;

##EQU11## wherein B is the attenuation of an average bony member and |H_t (f_i)| is the magnitude transfer function of said ultrasonic transducer, thereby producing a bone-transmitted acoustic signal for bone therapy.

2. The method of claim 1, wherein status of the bone tissue is evaluated concurrently with the therapeutic treatment and said transducer is one of two transducers coupled to nearby skin on opposite sides of said bony part, the other of said transducers being adapted for receiving signals that have propagated through said bony part, said method including the further steps of:

(c) sequentially processing each electrical-output signal by averaging a succession of signals to obtain an averaged per-pulse signal, each averaging being over a predetermined minimum period of time exceeding substantially one millisecond;

(d) selectively using said transducers and said excitation signal via a medium of known acoustic properties and path length, said selective use being independent of coupling to the living body, whereby to establish a reference signal;

(e) separately storing the reference signal; and

(f) comparatively evaluating the averaged per-pulse signal against the stored reference signal.