Iontophoretic delivery device and method of hydrating same
First Claim
1. A device including an electrode assembly for an electrically powered iontophoretic agent delivery, the electrode assembly comprising:
- a) a reservoir including a substantially non-hydrated hydratable matrix adapted to contain an agent to be delivered through a body surface, said reservoir being electrically connected to a power source;
b) a sealed container in fluid communication with the reservoir, the container containing a liquid for hydrating the substantially non-hydrated matrix, at least a portion of the container comprising a liquid impermeable material which is capable of being ripped or torn, the material having an inner surface which is exposed to the sealed hydrating liquid and an outer surface; and
c) a tab having one portion attached to the outer surface of the liquid impermeable material without passing through said material, whereby pulling the tab relative to the liquid impermeable material causes the material to rip or tear and release the liquid from the container and into the reservoir matrix.
1 Assignment
0 Petitions
Accused Products
Abstract
A dry-state iontophoretic drug delivery device (10, 30) is provided. The device has drug and electrolyte reservoirs (15, 16) which are initially in a non-hydrated condition. In one embodiment of the invention, a sealed liquid-containing pouch (21, 22) is provided in each electrode assembly (8, 9). Water or other liquid (20) is released from the pouch (21, 22) by pulling a tab (27, 28) attached to a portion (25, 26) of the pouch (21, 22) which is capable of being torn or ripped in order to hydrate the drug and electrolyte reservoirs (15, 16) and activate the device (10, 30). In another embodiment, the device (30) is held in a package (32). The device (30) has pouches (21, 22) which release their liquid contents automatically upon removal of the device (30) from the package (32). In yet another embodiment, the device (40) is held in a package (42) having a compression zone (46). The pouches (21, 22) must be moved through the compression zone (46) when removing the device (40) from the package (42). Compression causes the pouches (21, 22) to rupture and release the hydrating liquid (20).
230 Citations
27 Claims
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1. A device including an electrode assembly for an electrically powered iontophoretic agent delivery, the electrode assembly comprising:
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a) a reservoir including a substantially non-hydrated hydratable matrix adapted to contain an agent to be delivered through a body surface, said reservoir being electrically connected to a power source; b) a sealed container in fluid communication with the reservoir, the container containing a liquid for hydrating the substantially non-hydrated matrix, at least a portion of the container comprising a liquid impermeable material which is capable of being ripped or torn, the material having an inner surface which is exposed to the sealed hydrating liquid and an outer surface; and c) a tab having one portion attached to the outer surface of the liquid impermeable material without passing through said material, whereby pulling the tab relative to the liquid impermeable material causes the material to rip or tear and release the liquid from the container and into the reservoir matrix. - View Dependent Claims (2, 3, 6, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27)
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4. A packaged electrically powered iontophoretic agent delivery device having a donor electrode assembly, a counter electrode assembly and a power source electrically connected to the donor and counter electrode assemblies, at least one of the electrode assemblies comprising:
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a) a reservoir including a substantially non-hydrated, hydratable matrix adapted to contain an agent to be delivered through a body surface; and b) a sealed container in fluid communication with the reservoir, the container containing a liquid for hydrating the substantially non-hydrated matrix, at least a portion of the container comprising a liquid impermeable, breakable material; wherein the device is held in a package before use, said package having means operatively associated with the liquid impermeable material whereby removal of the device from the package causes said means to break the liquid impermeable material, thereby releasing the liquid from the container and into the reservoir matrix. - View Dependent Claims (5, 7)
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Specification