×

Method for the preparation of stable suspensions of hollow gas-filled microspheres suitable for ultrasonic echography

  • US 5,310,540 A
  • Filed: 05/06/1992
  • Issued: 05/10/1994
  • Est. Priority Date: 10/05/1990
  • Status: Expired due to Term
First Claim
Patent Images

1. A method for preparing stable aqueous suspensions of air or gas filled microbubbles suitable for ultrasonic applications in living organisms, said method comprising the steps of:

  • a) converting a viscous aqueous solution of a filmogenic protein into a foam of air or gas filled bubbles by whipping with air or a pharmaceutically acceptable gas to produce microbubbles bound by a membrane of said protein, and(b) subjecting, simultaneously or subsequently, the foaming solution to high shear by forcing it through narrow openings or channels for a time sufficient to reduce the size of the bubbles in the foam to values in a range of about 0.5-10 μ

    m suitable for injection.

View all claims
  • 3 Assignments
Timeline View
Assignment View
    ×
    ×