Composition and method for reparation and prevention of fibrotic lesions
First Claim
1. A pharmaceutical composition for reparation and prevention of fibrotic lesional tissue in a mammal, comprising 5-methyl-1-phenyl-2-(1H)-pyridone as an active anti-fibrotic ingredient present in an internally administered dosage form in an amount of from about 25 mg per kilogram of body weight per day to about 150 mg per kilogram of body weight per day.
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Abstract
In a preferred embodiment, drugs having heretofore unknown pharmacological properties which are useful in the medicinal therapy of fibrotic disease for the reparation and prevention of fibrotic lesional tissues, such drugs including as the active ingredient 5-methyl-1-phenyl-2-(1H)-pyridone. The pharmaceutical composition of this invention is novel as an anti-fibrotic drug, namely, as an agent for treating fibrosis. Any existing compounds have not been shown to be effective for the reparation and prevention of fibrotic lesions.
106 Citations
18 Claims
- 1. A pharmaceutical composition for reparation and prevention of fibrotic lesional tissue in a mammal, comprising 5-methyl-1-phenyl-2-(1H)-pyridone as an active anti-fibrotic ingredient present in an internally administered dosage form in an amount of from about 25 mg per kilogram of body weight per day to about 150 mg per kilogram of body weight per day.
- 4. A method for the reparation and prevention of fibrotic lesional tissue in a mammal, comprising administering topically to said mammal a pharmaceutical composition containing 5-methyl-1-phenyl-2-(1H)-pyridone as an active anti-fibrotic ingredient in an amount of from about 5% to about 10%.
- 7. A method for the reparation and prevention of fibrotic lesional tissue in a mammal, comprising administering internally to said mammal a pharmaceutical composition containing 5-methyl-1-phenyl-2-(1H)-pyridone as an active anti-fibrotic ingredient, said composition being administered to said mammal at a rate of from about 25 mg per kilogram of body weight per day to about 150 mg per kilogram of body weight per day.
- 16. A pharmaceutical composition for reparation and prevention of fibrotic lesional tissue in a mammal, comprising 5-methyl-1-phenyl-2-(1H)-pyridone as an active anti-fibrotic ingredient present in a topically administered dosage form in an amount of from about 5% to about 10%.
Specification