Cardiac rhythm management device with automatic optimization of performance related pacing parameters

• US 5,312,452 A
• Filed: 11/03/1992
• Issued: 05/17/1994
• Est. Priority Date: 11/03/1992
• Status: Expired due to Term

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Salo, Rodney W.
• Primary Examiner(s): Cohen, Lee S.
• Assistant Examiner(s): Parker, Marianne
• Application Number:
  US07/970,892
• Time in Patent Office: 560 Days
• Field of Search: 607/11-13, 607/25-28, 607/64, 607/14, 607/17, 607/19, 128/703, 128/706
• US Class Current: 607/17
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/3682 with a variable atrioventricular delay

Abstract

A dual chamber cardiac pacemaker incorporating a microprocessor-based controller which is programmed to automatically establish an A-V interval at a value which provides optimum cardiac function but without the need for a special sensor for measuring cardiac function is described. The microprocessor is programmed to continuously monitor heart rate and variation in heart rate and only when the patient is stable, enter a parameter adjustment loop in which the pacemaker'"'"'s A-V interval is incremented in several discrete steps and for each step, the corresponding average steady-state heart rate is measured and stored. When the A-V interval incrementation process causes that interval to reach a predetermined upper limit, the pacemaker'"'"'s A-V interval is set at the value that corresponds with the minimum average heart rate to thereby maximize cardiac performance.

Claims

1. A cardiac pacemaker comprising;

(a) means for sensing atrial and ventricular depolarization signals;

(b) a variable frequency pulse generator having a control input and an output;

(c) means for coupling said output to at least one ventricle;

(d) control means coupled to said control input of said variable frequency pulse generator and to said means for sensing atrial and ventricular depolarization signals, said control means including a microprocessor having a memory for storing state information therein, said microprocessor being programmed to periodically compute heart rate and variations in said heart rate and incrementally adjust an A-V delay interval between the sensing of an atrial depolarization signal and a next ensuing output from said variable frequency pulse generator from a lower limit toward an upper limit only when said heart rate is determined to be stable and variations in said heart rate are determined to be below a predetermined threshold and to store for each incremental adjustment of A-V interval that A-V interval and a corresponding steady state mean heart rate value; and

means responsive to said A-V interval reaching said upper limit for reading out from said memory the state information consisting of the stored A-V interval value corresponding to the lowest stored value of mean heart rate, said control means then using that A-V interval value in controlling operation of said variable frequency pulse generator.

2. The cardiac pacemaker as in claim 1 wherein said predetermined threshold is a programmable parameter.

3. The cardiac pacemaker as in claim 1 wherein said predetermined threshold for heart rate is set by said microprocessor to a value which is greater than the lowest mean heart rate value stored in said memory during a preceding time interval.

4. The cardiac pacemaker as in claim 3 wherein said predetermined threshold for variations in heart rate is a predetermined percentage of the difference between maximum and minimum mean heart rate values stored in said memory during a preceding time interval.

5. The cardiac pacemaker as in either of claims 3 or 4 wherein said preceding time interval is in a range of from 12 hours to 24 hours.

6. A method of operating a cardiac pacemaker, said pacemaker being of a dual chamber type having means for sensing atrial and ventricular depolarization signals and pulse generator means for applying stimulating pulses to at least one ventricle following a predetermined A-V interval from an occurrence of a preceding atrial depolarization signal and a microprocessor-based controller having a memory means for storing state variables therein, said controller being coupled to said sensing means and in controlling relation to said pulse generator means, comprising the steps of;

(a) monitoring heart rate and heart rate variability;

(b) setting the A-V interval to a minimum value when the monitored heart rate and heart rate variability are each below associated threshold values;

(c) continuing to monitor heart rate and variability following step (b) so long as the heart rate and heart rate variability remain below said threshold value until the heart rate reaches a steady state value;

(d) storing a mean heart rate value and associated A-V delay value in said memory means;

(e) incrementing said A-V interval from said minimum value and repeating steps (c) and (d) until the A-V interval reaches a predetermined maximum value;

(f) reading from said memory means the A-V interval associated with said minimum mean heart rate; and

(g) using the A-V interval read out from said memory for controlling said pulse generator means.