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Anticoagulant analogues of the tissue factor extrinsic pathway inhibitor (EPI) with reduced affinity for heparin

  • US 5,312,736 A
  • Filed: 01/27/1992
  • Issued: 05/17/1994
  • Est. Priority Date: 08/18/1989
  • Status: Expired due to Fees
First Claim
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1. An analogue of extrinsic pathway inhibitor (EPI) which analogue is a derivative of the full-length EPI sequence depicted in SEQ ID NO:

  • 1, and which analogue retains the anticoagulant activity of native EPI as well as anti-FXa activity, comprises the three Kunitz protease inhibitor domains present in EPI, but has a heparin binding capacity less than 50% of the heparin binding capacity of native EPI when each is contacted with immobilized heparin under physiological conditions.

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