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Method for measurement of fructosamines using 1,2-quinones

  • US 5,312,759 A
  • Filed: 08/02/1991
  • Issued: 05/17/1994
  • Est. Priority Date: 12/20/1989
  • Status: Expired due to Term
First Claim
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1. A method for measurement of fructosamines in an aqueous liquid which comprises the steps of:

  • (a) bringing an aqueous liquid sample into contact with a 1,2-quinone compound of the general formula;

    ##STR8## wherein, B3 and B4 are respectively hydrogen atoms or are atoms necessary for forming a benzene ring or a pyridine ring together with the two carbon atoms in the formula, and B5 and B6 are atoms necessary for forming a benzene ring or a pyrrole ring together with the two carbon atoms in the formula, said pyridine being substituted by carboxylic acid groups and said pyrrole ring being substituted by a carboxylic acid group, at a pH of from 8.5 to 11;

    (b) bringing the product of step (a) into contact with a reagent for measuring hydrogen peroxide for measuring hydrogen peroxide resulting from the reaction of step (a) between said 1,2-quinone compound and said fructosamines; and

    (c) measuring a detectable change in the reagent of step (b).

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