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Tissue factor based prothrombin time reagent

  • US 5,314,695 A
  • Filed: 10/29/1991
  • Issued: 05/24/1994
  • Est. Priority Date: 11/13/1990
  • Status: Expired due to Term
First Claim
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1. A prothrombin time reagent containing purified natural or recombinant tissue factor which comprises a liposome composition comprising:

  • (a) a phospholipid mixture comprising;

    (i) from about 20 to about 95 mole percent phosphatidylcholine,(ii) from about 2.5 to about 50 mole percent phosphatidylethanolamine,(iii) from about 2.5 to about 50 mole percent phosphatidylserine, and(iv) from about 0 to 40 mole percent phosphatidylglycerol; and

    (b) from about 0.1 μ

    g to about 3 μ

    g of tissue factor per mg phospholipid mixture.

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