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Method for imaging informational biological molecules on a semiconductor substrate

  • US 5,314,829 A
  • Filed: 12/18/1992
  • Issued: 05/24/1994
  • Est. Priority Date: 12/18/1992
  • Status: Expired due to Fees
First Claim
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1. A method of imaging molecular strands using a substrate having a plurality of straight grooves in a top surface of said substrate, each of said grooves being of a size capable of holding only a single individual one of said molecular strands along any one section of a length of the groove, and being capable of forcing single individual molecular strands into a straight position when positioned in one of said plurality of grooves, said method comprising:

  • preparing a specimen of said molecular strands and depositing said specimen onto said top surface;

    aligning and depositing individual ones of said molecular strands into individual ones of said plurality of grooves whereby the shape and size of each groove forces the molecular strands into a straight position; and

    recording a first image of a selected section of said top surface of said substrate having at least one of said molecular strands in one of said grooves using an atomic imaging device.

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