Immobilized hydrophobically-modified antibodies
First Claim
Patent Images
1. A protein modified with a hydrophobic moiety attached to the protein by a spacer comprising a water-soluble polymer, directly adsorbed onto an unprimed microporous mineral body surface.
1 Assignment
0 Petitions
Accused Products
Abstract
The invention comprises stable, antigen-sensitive surfaces containing immobilized antibody modified with a polyethylene glycol spacer arm including a terminal hydrophobic moiety. The surfaces are generally useful in immunoassay procedures, especially microgravimetric assays such as those employing antibody immobilized on piezoelectric crystal surfaces.
-
Citations
24 Claims
- 1. A protein modified with a hydrophobic moiety attached to the protein by a spacer comprising a water-soluble polymer, directly adsorbed onto an unprimed microporous mineral body surface.
- 21. A method for preparing an immunoreactive surface, comprising coating an unprimed microporous mineral body surface with an antigen or antibody modified with a hydrophobic moiety attached to the antigen or antibody by a spacer comprising a water-soluble polymer by drying the modified antigen or antibody onto the unprimed surface.
Specification