Benzopyran class III antiarrhythmic agents
First Claim
1. A compound of the formula ##STR15## or a pharmaceutically acceptable salt;
- wherein n is 0, 1 or 2;
wherein R is H or lower alkyl of 1 to 6 carbon atoms;
wherein X is selected from the group consisting of hydrogen, methane sulfonamide, nitro, cyano, imidazolyl, alkoxy of 1 to 6 carbon atoms and hydroxy; and
wherein Ar is selected from the group consisting of pyridinyl and benzofuranyl optionally substituted by methane sulfonamide, nitro, cyano or imidazolyl.
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Abstract
The present invention relates to compounds of the formula ##STR1## or a pharmaceutically acceptable salt thereof; wherein n is 0, 1 or 2;
wherein R is H or lower alkyl of 1 to 6 carbon atoms;
wherein X is selected from the group consisting of hydrogen, methane sulfonamide, nitro, cyano, imidazolyl, alkoxy of 1 to 6 carbon atoms and hydroxy; and
wherein Ar is selected from the group consisting of pyridinyl and benzofuranyl optionally substituted by methane sulfonamide, nitro, cyano, or imidazolyl with the proviso that when n is 1, Ar is other then phenyl;
pharmaceutical compositions containing these compounds and a method for treating cardiac arrhythmias in mammals by administering the compositions.
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Citations
27 Claims
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1. A compound of the formula ##STR15## or a pharmaceutically acceptable salt;
- wherein n is 0, 1 or 2;
wherein R is H or lower alkyl of 1 to 6 carbon atoms; wherein X is selected from the group consisting of hydrogen, methane sulfonamide, nitro, cyano, imidazolyl, alkoxy of 1 to 6 carbon atoms and hydroxy; and wherein Ar is selected from the group consisting of pyridinyl and benzofuranyl optionally substituted by methane sulfonamide, nitro, cyano or imidazolyl. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
- wherein n is 0, 1 or 2;
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14. A pharmaceutical composition comprising a therapeutically effective amount of a compound of the formula ##STR16## or a pharmaceutically acceptable salt thereof;
- wherein n is 0, 1 or 2;
wherein R is H or lower alkyl of 1 to 6 carbon atoms; wherein X is selected from the group consisting of hydrogen, methane sulfonamide, nitro, cyano, imidazolyl, alkoxy of 1 to 6 carbon atoms and hydroxy; and wherein Ar is selected from the group consisting of pyridinyl and benzofuranyl optionally substituted by methane sulfonamide, nitro, cyano or imidazolyl; and a pharmaceutically acceptable carrier. - View Dependent Claims (15, 16, 17, 18, 19, 20)
- wherein n is 0, 1 or 2;
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21. A method of treating cardiac arrhythmias in mammals comprising administering to a patient in need of such treatment, a therapeutically effective amount of a compound of the formula ##STR17## or a pharmaceutically acceptable salt thereof;
- wherein n is 0, 1 or 2;
wherein R is H or lower alkyl of 1 to 6 carbon atoms; wherein X is selected from the group consisting of hydrogen, methane sulfonamide, nitro, cyano, imidazolyl, alkoxy of 1 to 6 carbon atoms and hydroxy; and wherein Ar is selected from the group consisting of pyridinyl and benzofuranyl optionally substituted by methane sulfonamide, nitro, cyano or imidazolyl. - View Dependent Claims (22, 23, 24, 25, 26, 27)
- wherein n is 0, 1 or 2;
Specification