Booster for therapy of diseases with ultrasound and pharmaceutical liquid composition containing the same

• US 5,315,998 A
• Filed: 03/20/1992
• Issued: 05/31/1994
• Est. Priority Date: 03/22/1991
• Status: Expired

• Current Assignee: Katsuro Tachibana, Shunro Tachibana
• Original Assignee: Katsuro Tachibana, Shunro Tachibana
• Inventors: Tachibana, Katsuro, Tachibana, Shunro
• Primary Examiner(s): Rosenbaum, C. Fred
• Assistant Examiner(s): Rafa, Michael
• Application Number:
  US07/855,545
• Time in Patent Office: 802 Days
• Field of Search: 609/22, 128/24 AA, 128/24 R, 128/667.02, 128/660.01, 424/2, 424/9
• US Class Current: 601/2
• CPC Class Codes: A61K 41/0004 Homeopathy; Vitalisation; Resonance; Dynamisation, e.g. esoteric applications; Oxygenation of blood
• CPC Class Codes: A61K 41/0028 Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
• CPC Class Codes: A61K 41/0047 Sonopheresis, i.e. ultrasonically-enhanced transdermal delivery, electroporation of a pharmacologically active agent
• CPC Class Codes: A61K 49/223 Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
• CPC Class Codes: A61K 9/0009 involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis microelectromechanical systems A61K9/0097
• CPC Class Codes: A61K 9/5052 Proteins, e.g. albumin

Abstract

A booster comprising a plenty of microbubbles of a gas in a liquid, e.g. about 4×10⁷ cells/ml of microbubbles of a gas having a diameter of 0.1 to 100 μm in a 3 to 5% human serum albumin solution, and a pharmaceutical liquid composition comprising the booster as set forth above and a medicament, which are useful for the therapy of various diseases together with exposure of ultrasonic, where the therapeutic effects of the medicament is enhanced by the application of ultrasound in the presence of the booster.

Claims

1. A booster for enhancing effects of ultrasound in the therapy of diseases, which comprises:

a. a medicament and

b. microbubbles of a gas having a diameter of 0.1 to 100 μ

m in a liquid.

2. The booster according to claim 1, wherein the microbubbles are formed from air or oxygen gas in the liquid.

3. The booster according to claim 1, wherein the liquid is a 3 to 5% human serum albumin solution.

4. A pharmaceutical liquid composition for the therapy of diseases with application of ultrasound, which comprises:

a. microbubbles of a gas having a diameter of 0.1 to 100 μ

m and

b. a medicament selected from the group consisting of thrombolytic agents, hormones, antibiotics and antineoplastic agents in a liquid.

5. The composition according to claim 4, wherein the microbubbles are formed from air or oxygen gas in the liquid.

6. The composition according to claim 4, wherein the liquid is a 3 to 5% human serum albumin solution.

7. The composition according to claim 4, wherein the medicament is a member selected from thromobolytic agents, hormones, antibiotics, and antineoplastic agents.

8. The composition according to claim 4, wherein the medicament is selected from the group consisting of urokinase, tissue plasminogen activator, insulin, theophylline, and lidocaine.

9. A method for enhancing the therapeutic effects of a medicament, comprising:

a. applying ultrasound to a pharmaceutical liquid composition according to claim 4 and

b. administering said pharmaceutical liquid composition.

10. The method according to claim 9, wherein the liquid composition comprises about 4×

10⁷ cells/ml of microbubbles of a gas having a diameter of 0.1 to 100 μ

m and a medicament in the liquid.

11. The method according to claim 10, wherein the liquid is a 3 to 5% human serum albumin solution.

12. The method according to claim 9, wherein the medicament is selected from the group consisting of urokinase, tissue plasminogen activator, insulin, theophylline, and lidocaine.

13. A method of dosing subjects with a pharmaceutical preparation by:

a. applying ultrasound to a pharmaceutical liquid composition and

b. administering said pharmaceutical liquid composition comprising microbubbles of a gas having a diameter of 0.1 to 100 μ

m and a medicament in a liquid in the therapy of diseases.

14. The method of dosing according to claim 13, wherein the microbubbles are formed from air or oxygen gas in the liquid.

15. The method of dosing according to claim 13, wherein the liquid is a 3 to 5% human serum albumin solution.

16. The method of dosing according to claim 13, wherein the medicament is selected from the group consisting of urokinase, tissue plasminogen activator, insulin, theophylline, and lidocaine.