Polyarylates containing derivatives of the natural amino acid l-tyrosine
First Claim
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1. A method for the polymerization of polyarylates comprising:
- mixing equimolar quantities of;
(a) a diphenol having a structure represented by the formula;
##STR12## wherein X is selected from the group consisting of --H, --NHL1, --NL1 L2,;
##STR13## Y is selected from the group consisting of hydrogen and ester groups having the structure;
##STR14## wherein L1, L2 and L3 are independently selected from the group consisting of straight or branched alkyl and alkylaryl groups containing up to 18 carbon atoms; and
(b) a dicarboxylic acid having a structure represented by the formula;
##STR15## wherein R is selected from the group consisting of saturated and unsaturated, substituted and unsubstituted alkyl, aryl and alkylaryl groups containing up to 18 carbon atoms;
together with a catalytic amount of 4-(dimethylamino)pyridinium-p-toluene sulfonate (DPTS) in a solvent for said polyarylate; and
adding at least one molar equivalent per mole of carboxylic acid groups present of a carbodiimide, so that a polyarylate is formed comprised of recurring structural units represented by the formula;
##STR16## .
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Abstract
Bioerodible polyarylates derived from biocompatible dicarboxylic acids and natural amino acid-derived diphenol starting materials. Molded articles and controlled drug delivery systems prepared from the polyarylates are also disclosed.
72 Citations
13 Claims
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1. A method for the polymerization of polyarylates comprising:
mixing equimolar quantities of; (a) a diphenol having a structure represented by the formula;
##STR12## wherein X is selected from the group consisting of --H, --NHL1, --NL1 L2,;
##STR13## Y is selected from the group consisting of hydrogen and ester groups having the structure;
##STR14## wherein L1, L2 and L3 are independently selected from the group consisting of straight or branched alkyl and alkylaryl groups containing up to 18 carbon atoms; and(b) a dicarboxylic acid having a structure represented by the formula;
##STR15## wherein R is selected from the group consisting of saturated and unsaturated, substituted and unsubstituted alkyl, aryl and alkylaryl groups containing up to 18 carbon atoms;together with a catalytic amount of 4-(dimethylamino)pyridinium-p-toluene sulfonate (DPTS) in a solvent for said polyarylate; and adding at least one molar equivalent per mole of carboxylic acid groups present of a carbodiimide, so that a polyarylate is formed comprised of recurring structural units represented by the formula;
##STR16## .- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
Specification