Ultrasonic ablation/dissolution transducer

• US 5,318,014 A
• Filed: 09/14/1992
• Issued: 06/07/1994
• Est. Priority Date: 09/14/1992
• Status: Expired due to Term

• Current Assignee: Coraje, Inc.
• Original Assignee: Coraje, Inc.
• Inventors: Carter, Robert E.
• Primary Examiner(s): Smith, Ruth S.
• Application Number:
  US07/945,275
• Time in Patent Office: 631 Days
• Field of Search: 128/24 AA, 128/24 FL, 128/660.03, 604/22, 604/27, 604/28, 606/128, 606/27, 606/28, 606/169-170
• US Class Current: 606/128
• CPC Class Codes: A61B 17/2202 the ultrasound transducer being inside patient's body at the distal end of the catheter
• CPC Class Codes: A61B 2017/22002 preventing restenosis
• CPC Class Codes: A61B 2017/22008 used or promoted
• CPC Class Codes: A61B 2017/22021 electric leads passing through the catheter
• CPC Class Codes: A61B 2017/22082 after introduction of a substance
• CPC Class Codes: A61M 37/0092 using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis

Abstract

Ultrasonic apparatus for clot dissolution includes a radiator for coupling ultrasonic waves and a piezoelectric crystal, connected with said radiator, for the intravascular generation of ultrasonic waves; said ultrasonic waves being propagated along a longitudinal axis of said piezoelectric crystal. A seed liquid is introduced proximate the radiator for promoting cavitation of intravascular fluid. In addition, enhancement of clot dissolution by chemical agents is shown to be significantly increased when combined with ultrasonic energy.

Claims

1. Ultrasonic apparatus for clot dissolution comprising:

radiator means for coupling ultrasonic waves into intravascular fluids including clots, said radiator means being sized for intravascular insertion;

means, connected with said radiator means, for the generation of ultrasonic waves; and

separate means for promoting cavitation of the intravascular fluid proximate the radiator means.

2. The apparatus according to claim 1 wherein the means for promoting cavitation comprises lumen means for introducing a seed fluid into the intravascular fluid proximate the radiator means.

3. The apparatus according to claim 1 further comprising a seed fluid and the means for causing cavitation comprises lumen means for introducing the seed fluid into the intravascular fluid proximate the radiator means.

4. The apparatus according to claim 3 wherein the seed fluid comprises an aqueous saline solution containing carbon dioxide.

5. The apparatus according to claim 4 wherein the carbon dioxide content in the aqueous saline solution is at most about 10 gms weight per liter of solution.

6. The apparatus according to claim 4 further comprising means for storing the aqueous saline solution at a pressure greater than atmospheric pressure and means for transferring the pressurized aqueous saline solution into the lumen means.

7. The apparatus according to claim 6 further comprising means, separate from said radiator means, for controlling clot dissolution.

8. The apparatus according to claim 7 wherein the means for controlling the clot dissolution rate comprises valve means for controlling the flow of the seed fluid into the lumen means.

9. The apparatus according to claim 7 wherein the means for controlling the clot dissolution rate comprises means for introducing a composition into the intravascular fluid proximate the radiator, said composition having clot dissolution activity.

10. Ultrasonic surgical apparatus for clot dissolution comprising:

a catheter having at least one lumen therethrough and adapted for intravascular positioning;

an ultrasonic transducer disposed in the catheter lumen at a distal end thereof, said ultrasonic transducer comprising;

radiator means for coupling ultrasonic waves into clots;

piezoelectric crystal means, connected with said radiator means, for generating ultrasonic waves;

means for promoting cavitation of intravascular fluid proximate the radiator means; and

power source means, disposed exterior to a proximate end of said catheter and electrically connected to said ultrasonic transducer through said catheter lumen, for causing said piezoelectric crystal to generate ultrasonic waves.

11. The apparatus according to claim 10 wherein the means for promoting cavitation comprises lumen means for introducing a seed fluid into the intravascular fluid proximate the radiator means.

12. The apparatus according to claim 10 further comprising a seed fluid and the means for promoting cavitation comprises lumen means for introducing the seed fluid into the intravascular fluid proximate the radiator means.

13. The apparatus according to claim 12 wherein the seed fluid comprises an aqueous saline solution containing carbon dioxide.

14. The apparatus according to claim 13 wherein the carbon dioxide content in the aqueous saline solution is at most about 10 gms weight per liter of solution.

15. The apparatus according to claim 14 further comprising means for storing the aqueous saline solution at a pressure greater than atmospheric pressure and means for transferring the pressurized aqueous saline solution into the lumen means.

16. The apparatus according to claim 15 further comprising means, separate from said radiator mans, for controlling a clot dissolution rate.

17. The apparatus according to claim 16 wherein the means for controlling the clot dissolution comprises valve means for controlling the flow of the seed fluid into the lumen means.

18. The apparatus according to claim 16 wherein the means for controlling the clot dissolution rate comprises means for introducing a composition into the intravascular fluid proximate the radiator means, said composition having clot dissolution activity.

19. A method for dissolving intravascular clots, said method comprising the steps of:

introducing ultrasonic waves proximate intravascular clots comprising inserting a catheter, having an ultrasonic transducer on one end thereof, into a vessel and positioning the ultrasonic transducer proximate the intravascular clot; and

providing means for promoting cavitation of intravascular fluid proximate the intravascular clots.

20. The method according to claim 19 wherein the step of providing mans for promoting cavitation comprises introducing a seed fluid into the intravascular fluid proximate the clot.

21. The method according to claim 19 wherein the step of providing means for promoting cavitation comprises introducing an aqueous saline solution, containing carbon dioxide, into the intravascular fluid, proximate the clots.

22. The method according to claim 19 wherein the step of providing means for promoting cavitation comprises introducing an aqueous saline solution, at a pressure greater than about 1 atmosphere, into the intravascular fluid proximate the clots.