Device for the preparation of a solution for medical use

• US 5,318,750 A
• Filed: 02/12/1993
• Issued: 06/07/1994
• Est. Priority Date: 02/14/1992
• Status: Expired due to Term

• Current Assignee: Jean-Jacques Lascombes
• Original Assignee: Jean-Jacques Lascombes
• Inventors: Lascombes, Jean-Jacques
• Primary Examiner(s): Housel, James C.
• Assistant Examiner(s): REDDING, DAVID A
• Application Number:
  US08/017,153
• Time in Patent Office: 480 Days
• Field of Search: 422/81, 422/82, 422/82.02, 422/101, 422/110, 422/278, 422/279, 422/44, 137/268, 366/152, 366/172, 366/177, 366/178, 210/645-647, 604/4, 604/5, 604/6
• US Class Current: 422/81
• CPC Class Codes: A61J 3/002 Compounding apparatus specially for enteral or parenteral nutritive solutions bottling liquids B67C
• CPC Class Codes: A61M 1/1656 Apparatus for preparing dialysates
• CPC Class Codes: A61M 1/1666 by dissolving solids
• CPC Class Codes: A61M 1/1668 Details of containers
• CPC Class Codes: A61M 1/3609 Physical characteristics of the blood, e.g. haematocrit, urea
• CPC Class Codes: Y10T 137/4891 With holder for solid, flaky or pulverized material to be dissolved or entrained

Abstract

A device for the extemporaneous and continuous preparation of a solution for dialysis by the dissolution of several substances in powder form in water. The device includes a number of independent cartridges each containing a salt of a substance necessary for the preparation of the dialyzate, such as sodium chloride, potassium chloride, calcium chloride, magnesium chloride, and sodium bicarbonate. The device includes at least one first conduit communicating with an inlet to the cartridges for introducing water into the cartridges to produce aqueous solutions in said cartridges, at least one second conduit communicating with an outlet from said cartridges for bringing the aqueous solutions to mixing point located upstream from a dialysis circuit, a first measurement device mounted on the second conduit upstream from the mixing point, for measuring the concentration of the aqueous solutions at the outlet of the cartridges, a second measurement device mounted downstream from the dialysis circuit, and at least one flow-rate regulating device for regulating the flow rate of the water to modify the concentration of the aqueous solutions in response to the information provided by the first and second measurement devices.

Claims

1. A device for the preparation of a solution for medical use by the dissolution of several substances in powder form in a carrier fluid, comprising:

a plurality of cells, each containing at least one of said substances in powder form,

at least one first conduit having a first end communicating with a source of carrier fluid and a second end communicating with each of said plurality of said cells for introducing said carrier fluid into each of said plurality of said cells to produce aqueous solutions in each of said plurality of said cells,

at least one second conduit communicating with each of said plurality of said cells for bringing said aqueous solutions produced in each of said plurality of said cells to a mixing point located upstream from a site of utilization,

at least one measurement means mounted upstream from said mixing point, for measuring the concentration of said aqueous solutions produced in each of said plurality of said cells, and

at least one means for regulating flow rate of said carrier fluid into each of said plurality of said cells in order to modify the concentration of said aqueous solutions in each of said plurality of said cells in response at least to concentration measurements provided by said measurement means,

control means for collecting said concentration measurements from said measurement means and for operating said flow rate regulation means in order to modify the concentration of said aqueous solutions in each of said plurality of said cells in response at least to concentration measurements provided by said measurement means.

2. A device according to claim 1, wherein each of said cells contains a means for diffusion and circulation of said carrier fluid in said plurality of said cells.

17. A device according to claim 1, further comprising second measurement means to be mounted downstream from the site of utilization.

3. A device for extemporaneous and continuous preparation of a solution for use in combination with a dialysis circuit by the dissolution of several substances in powder form in water, comprising:

a plurality of independent cartridges, each containing at least one salt of a substance necessary for the preparation of said solution, said at least one salt being selected from the group consisting of sodium chloride, potassium chloride, calcium chloride, magnesium chloride and sodium bicarbonate,

at least one first conduit communicating with an inlet of each of said plurality of said cartridges for introducing water into said cartridges for producing solute in said cartridges,

at least one second conduit communicating with an outlet from said cartridges for bringing said solute to a mixing point located upstream from the dialysis circuit,

at least one measurement means mounted on said second conduit upstream from said mixing point, for measuring concentration of said solute produced in said cartridges, and

at least one means of flow-rate regulation for regulating the flow rate of the water into each of said plurality of said cartridges in order to modify the concentration of said solute in response to the concentration measurements provided by said at least one measurement means,

control means for collecting said concentration measurements from said at least one measurement means and for operating said flow-rate regulation means in order to modify the concentration of said solute in each of said cartridges in response to concentration measurements provided by said at least one measurement means.

4. A device according to claim 3, wherein each of said plurality of said cartridges contains means of diffusion and of circulation of water between said inlet and outlet of each of said plurality of said cartridges.

5. A device according to claim 4, wherein said diffusion and circulation means is disposed substantially along a longitudinal axis of each of said plurality of said cartridges.

6. A device according to claim 4, wherein said diffusion and circulation means comprises at least one semipermeable membrane fiber.

7. A device according to claim 6, wherein sizes of each of said plurality of cartridges and fibers are selected wherein the concentration, in millimoles of ions per liter, in the dialysis solution obtained is within the following ranges:

from 135 to 150 mmol of sodium ion,

from 1 to 3 mmol of potassium ion,

from 0 to 1.75 mmol of calcium ion,

from 0.25 to 1 mmol of magnesium ion,

from 25 to 35 mmol of bicarbonate ion.

8. A device according to claim 3, wherein said means for regulating the flow rate of the water is mounted on said first conduit.

9. A device according to claim 3, wherein said means for regulating the flow rate of the water is mounted on said second conduit.

10. A device according to claim 3, wherein said mixing point comprises third conduit mounted at an inlet of said dialysis circuit.

11. A device according to claim 3, wherein one of said at least one measurement means comprises conductivity cell.

12. A device according to claim 3, wherein said means for regulating the flow rate comprise variable-flow-rate pumps.

13. A device according to claim 10, further comprising means for measuring pH of a mixture in said third conduit.

14. A device according to claim 10, further comprising means for introducing into said third conduit, at least one substance selected from the group consisting of glucose, amino acids and oligo-elements.

15. A device according to claim 3, further comprising means for thermally regulating the solute at a selected temperature.

16. A device according to claim 3, wherein each of said plurality of cartridges are housed in an enclosure.

18. A device according to claim 3, further comprising second measurement means to be mounted downstream from the dialysis circuit.