Delivery system comprising first walled section and second walled section united by fusion, adhesion or telescopic engagement

• US 5,320,616 A
• Filed: 11/07/1991
• Issued: 06/14/1994
• Est. Priority Date: 12/13/1988
• Status: Expired due to Term

• Current Assignee: ALZA Corporation (Johnson & Johnson)
• Original Assignee: ALZA Corporation (Johnson & Johnson)
• Inventors: Magruder, Judy A., Eckenhoff, James B., Wright, Jeremy C., Peery, John R., Cortese, Richard
• Primary Examiner(s): Rosenbaum, C. Fred
• Assistant Examiner(s): STRIGHT, RONALD K
• Application Number:
  US07/789,241
• Time in Patent Office: 950 Days
• Field of Search: 604/890.1-892.1, 604/27, 604/48, 604/49, 424/422, 424/438, 424/473, 424/423
• US Class Current: 604/892.1
• CPC Class Codes: A61K 9/0004 Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
• CPC Class Codes: A61M 31/002 Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50

Abstract

A delivery system is disclosed for delivering a beneficial agent to an animal. The delivery system comprises a wall that surrounds a lumen, said wall comprising a composition that limits the passage of fluid into the system and a composition that permits the passage of fluid into the system. The lumen comprises a beneficial agent and an expandable member. The delivery system comprises an exit means for delivering the beneficial agent.

Claims

1. A delivery system for delivering a beneficial agent to a fluid environment of use, wherein the delivery system comprises:

(a) two wall sections, said sections comprising;

(b) a first wall section comprising a polymer composition that substantially limits the passage of zero to one ml per day of fluid through the first wall section;

(c) a second wall section comprising a cellulosic polymer composition pervious to the passage of fluid, which first wall section and second wall section surround;

(d) a reservoir formed by the two sections assembled together by at least one process selected from fusion, adhesion and telescopic engagement;

(e) 5 nanograms to 40 grams of a fluid sensitive biological beneficial agent in the reservoir and surrounded by the first wall section for protecting the beneficial agent from the fluid;

(f) 0.1% to 90% of a pharmaceutically acceptable carrier in the reservoir surrounded by the first wall section and blended with the beneficial agent for transporting the beneficial agent from the reservoir;

(g) a composition comprising a fluid absorbing hydrophilic polymer for expanding and pushing the beneficial agent from the first wall section of the reservoir, said composition in the reservoir surrounded by the second wall section pervious to the passage of fluid; and

(h) an exit in the first wall section connecting the beneficial agent with the environment of use for delivering the beneficial agent at a hydrodynamically controlled rate over time.

2. The delivery system for delivering the beneficial agent according to claim 1, wherein the beneficial agent is a member selected from the group consisting of a pharmacologically active peptide, protein, anabolic hormone, growth promoting hormone, endocrine hormone, porcine growth promoting hormone, bovine growth promoting hormone, equine growth promoting hormone, human growth promoting hormone, and growth promoting hormone produced by recombinant DNA.

3. The delivery system for delivering the beneficial agent according to claim 1, wherein the delivery system is an implant.