Delivery system comprising first walled section and second walled section united by fusion, adhesion or telescopic engagement
First Claim
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1. A delivery system for delivering a beneficial agent to a fluid environment of use, wherein the delivery system comprises:
- (a) two wall sections, said sections comprising;
(b) a first wall section comprising a polymer composition that substantially limits the passage of zero to one ml per day of fluid through the first wall section;
(c) a second wall section comprising a cellulosic polymer composition pervious to the passage of fluid, which first wall section and second wall section surround;
(d) a reservoir formed by the two sections assembled together by at least one process selected from fusion, adhesion and telescopic engagement;
(e) 5 nanograms to 40 grams of a fluid sensitive biological beneficial agent in the reservoir and surrounded by the first wall section for protecting the beneficial agent from the fluid;
(f) 0.1% to 90% of a pharmaceutically acceptable carrier in the reservoir surrounded by the first wall section and blended with the beneficial agent for transporting the beneficial agent from the reservoir;
(g) a composition comprising a fluid absorbing hydrophilic polymer for expanding and pushing the beneficial agent from the first wall section of the reservoir, said composition in the reservoir surrounded by the second wall section pervious to the passage of fluid; and
(h) an exit in the first wall section connecting the beneficial agent with the environment of use for delivering the beneficial agent at a hydrodynamically controlled rate over time.
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Abstract
A delivery system is disclosed for delivering a beneficial agent to an animal. The delivery system comprises a wall that surrounds a lumen, said wall comprising a composition that limits the passage of fluid into the system and a composition that permits the passage of fluid into the system. The lumen comprises a beneficial agent and an expandable member. The delivery system comprises an exit means for delivering the beneficial agent.
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Citations
3 Claims
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1. A delivery system for delivering a beneficial agent to a fluid environment of use, wherein the delivery system comprises:
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(a) two wall sections, said sections comprising; (b) a first wall section comprising a polymer composition that substantially limits the passage of zero to one ml per day of fluid through the first wall section; (c) a second wall section comprising a cellulosic polymer composition pervious to the passage of fluid, which first wall section and second wall section surround; (d) a reservoir formed by the two sections assembled together by at least one process selected from fusion, adhesion and telescopic engagement; (e) 5 nanograms to 40 grams of a fluid sensitive biological beneficial agent in the reservoir and surrounded by the first wall section for protecting the beneficial agent from the fluid; (f) 0.1% to 90% of a pharmaceutically acceptable carrier in the reservoir surrounded by the first wall section and blended with the beneficial agent for transporting the beneficial agent from the reservoir; (g) a composition comprising a fluid absorbing hydrophilic polymer for expanding and pushing the beneficial agent from the first wall section of the reservoir, said composition in the reservoir surrounded by the second wall section pervious to the passage of fluid; and (h) an exit in the first wall section connecting the beneficial agent with the environment of use for delivering the beneficial agent at a hydrodynamically controlled rate over time. - View Dependent Claims (2, 3)
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Specification