Non-invasive testing

• US 5,321,265 A
• Filed: 07/15/1992
• Issued: 06/14/1994
• Est. Priority Date: 07/15/1992
• Status: Expired due to Term

• Current Assignee: Optix LP
• Original Assignee: Myron J. Block
• Inventors: Block, Myron J.
• Primary Examiner(s): Dzierzynski, Paul M.
• Assistant Examiner(s): HANIG, RICHARD E
• Application Number:
  US07/914,265
• Time in Patent Office: 699 Days
• Field of Search: 250/339, 250/340, 250/341, 250/343, 356/405
• US Class Current: 250/343
• CPC Class Codes: A61B 5/0059 using light, e.g. diagnosis by transillumination, diascopy, fluorescence A61B5/0093, A61B5/1455, A61B5/02416 and A61B5/0261 take precedence
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: G01N 2021/3137 with selection of wavelengths after the sample
• CPC Class Codes: G01N 21/359 using near infrared light
• CPC Class Codes: G01N 21/4795 spatially resolved investigating of object in scattering medium in vivo A61B

Abstract

A new non-invasive detection method for glucose and other constituents of interest in a sample has been developed. The apparatus and methods of the invention provide an analog of color perception of human vision, preferably in the near infrared region, replacing spectrophotometers and narrow band sources used in other noninvasive near infrared detection methods. A plurality of detector units are used, each covering a broad and overlapping region of the detected spectrum, paralleling color perception and colorimetry. In some circumstances, a neural net is used for analysis, allowing the system to learn. A novel method for background discrimination is also described.

Claims

1. An apparatus determining the concentration in a sample of a constituent of interest which has absorption or reflectance bands in a selected region of the spectrum comprising:

a light source that illuminates said sample with broad spectrum radiation in said selected region;

a sample chamber for confining said sample during said illumination;

detection means in the form of a plurality of detector units, each of said detector units being responsive to a specific region of said spectrum and having a partial overlapping region of spectral response with another of said detector units, said response from each detector unit being in the form of an output signal; and

analysis means for converting said output signals into a measure of said concentration.

2. The apparatus of claim 1 wherein said selected region of said spectrum is the near infrared region.

3. The apparatus of claim 1 when said detector means comprises at least three detector units each having a spectral response region centered about a different portion of said spectrum.

4. The apparatus of claim 3 wherein said detector units each generate signals that are near infrared analogs of the color receptive elements in vision.

5. The apparatus claim 4 wherein said analysis means generates an output which is a near infrared analog of a location in a colorimetric three dimensional space.

6. The apparatus of claim 3 wherein said detection means further comprises a black/white luminosity detector which is responsive to and overlaps the near infrared spectral response of said detector units.

7. The apparatus of claim 1 wherein said analysis means comprises an artificial neural network.

8. The apparatus of claim 1 wherein each of said detector units comprises broad bandpass filters.

9. The apparatus of claim 1 wherein said detector units comprise silicon photocells.

10. The apparatus of claim 1 wherein said sample chamber is arranged for non-invasive measurements on a portion of a human body.

11. The apparatus of claim 10 wherein said human body portion comprises a finger.

12. The apparatus of claim 10 wherein said constituent of interest is selected from the group consisting of glucose, and glucose indicating constituents.

13. The apparatus of claim 11 wherein said constituent of interest is selected form the group consisting of drugs of abuse, and drugs of abuse indicating constituents.

14. The apparatus of claim 1 further comprising a filter unit which has an absorption at the same spectral bands of said constituent of interest, the absorption of said filter unit corresponding to at least one order of magnitude greater concentration than the response of said constituent of interest.

15. The apparatus of claim 14 wherein said filter unit comprises a high concentration solution of said constituent of interest.

16. A method for measuring the concentration in a sample of a constituent of interest which absorbs or reflects light , said method comprising the steps of:

illuminating said sample with broad spectrum radiation;

detecting transmitted or reflected radiation from said sample;

generating at least one signal corresponding to said detected radiation; and

analyzing said signal to measure the concentration of said constituent;

wherein said detecting step includes impinging the radiation transmitted or reflected from said sample onto a detection array which generates said signal, said detection array including a plurality of detector units each responsive to a specific region of the transmitted or reflected spectrum, the spectral response of each of said detector units having at least partial overlap with the response of at least one other of said detector units.

17. The method of claim 16 wherein at least three detection units are used in said detecting step, each detector unit having a peak spectral response in a separate portion of said spectrum.

18. The method of claim 17 wherein said analysis step comprises forming from the output a near infrared analog of a specific position in a three dimension colorimetric space.

19. The method of claim 16 wherein said detector units comprise broad bandpass filters.

20. The method of claim 16 wherein said detecting step further comprises the use of a black/white detector unit which is responsive to the entire spectrum for which said detector units have a spectral response.

21. The method of claim 16 wherein said analysis step comprises utilizing an artificial analog of a neural network.

22. The method of claim 21 wherein said artificial neural network is calibrated and trained to process said signals to achieve an analog of color constancy in vision.

23. The method of claim 16 wherein said method is used for non-invasive testing for a constituent in a human body.

24. The method of claim 23 wherein said constituent is related from the group consisting of glucose and glucose indicating constituents.

25. The method of claim 23 wherein said constituent is selected form the group consisting of drugs of abuse and drugs of abuse indicating constituents.

26. The method of claim 23 wherein said sample comprises a finger.

27. An apparatus to perform colorimetry using absorption or reflectance in a selected region of the spectrum comprising:

a light source that generates broad spectrum radiation in said selected region;

detection means in the form of a plurality of detector units, each of said detector units being responsive to a specific region of said spectrum and having a partial overlapping region of spectral response with another of said detector units, said response from each detector unit being in the form of an output signal; and

analysis means in the form of a neural net for converting said output signals into colorimetry values.

28. A method for colormetric measures using transmittance or reflectance measurements comprising the steps of:

illuminating a sample with broad spectrum radiation;

detecting transmitted or reflected radiation from said sample;

generating at least one signal corresponding to said detected radiation; and

analyzing said signal to measure the concentration of said constituent;

wherein said detecting step includes impinging the radiation transmitted or reflected from said sample onto a detection array which generates said signal, said detection array including a plurality of detector units each responsive to a specific region of the transmitted or reflected spectrum, the spectral response of each of said detector units having at least partial overlap with the response of at least one other of said detector units;

and said analysis step is carried out using a neural net.

29. The method of claim 28 wherein said method is used to achieve substantial color constancy.