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Hydrophilic polyurethane membranes for electrochemical glucose sensors

  • US 5,322,063 A
  • Filed: 10/04/1991
  • Issued: 06/21/1994
  • Est. Priority Date: 10/04/1991
  • Status: Expired due to Term
First Claim
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1. A homogeneous membrane and an electrochemical glucose sensor combination, said electrochemical glucose sensor including means for evaluating the reaction of glucose and oxygen, said membrane adapted to control the diffusion of glucose and oxygen to the sensor elements, said membrane comprising a hydrophilic polyurethane composition comprising the product of the reaction mixture of:

  • a diisocyanate selected from the group consisting of hexamethylene-1,6-diisocyanate, dicyclohexylmethane 4,4'"'"'-diisocyanate, and isophorone diisocyanate, and constituting about 50 mole % of the reaction mixture;

    a poly(ethylene oxide) having an average molecular weight of about 600 to about 1500; and

    an aliphatic diol selected from the group consisting of ethylene glycol, diethylene glycol, 1,2-propanediol, 1,3-propanediol, and 1,4-butanediol,said membrane having an equilibrium water content of about 10% to about 50% and having a ratio of its diffusion coefficient for oxygen to its diffusion coefficient for glucose of up to about 4000, the poly(ethylene oxide) and aliphatic diol components constitute a total diol content of the reaction mixture the total diol content of the reaction mixture comprising from about 10% to about 50% poly(ethylene oxide) and from about 50% to about 90% aliphatic diol.

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