Membrane for electrotransport transdermal drug delivery
First Claim
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1. A device for administering a drug iontophoretically through a predetermined area of skin in a therapeutically effective regimen comprising:
- (a) a first reservoir of said drug in a form susceptible to iontophoretic administration in communication with said area of skin;
(b) a skin permeability enhancer contained within said first reservoir;
(c) a first electrode in electrical communication with said first reservoir;
(d) a second reservoir containing a electrolyte in communication with the skin at a location separated from said area of skin;
(e) a second electrode in electrical communication with the second reservoir;
(f) means for creating an electric voltage difference between the first and second electrodes; and
(g) a rate controlling membrane interposed between said first reservoir and said area of skin, said membrane being substantially impermeable to the drug when the voltage difference is absent and permeable to the drug when the voltage difference is present.
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Abstract
A membrane capable of inhibiting agent release from a delivery system when no electrical current is flowing and yet provide minimal impedance to electrically-assisted agent delivery, useful both for incorporating into electrotransport agent delivery systems and for use in measuring agent release rates in in vitro testing.
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Citations
17 Claims
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1. A device for administering a drug iontophoretically through a predetermined area of skin in a therapeutically effective regimen comprising:
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(a) a first reservoir of said drug in a form susceptible to iontophoretic administration in communication with said area of skin; (b) a skin permeability enhancer contained within said first reservoir; (c) a first electrode in electrical communication with said first reservoir; (d) a second reservoir containing a electrolyte in communication with the skin at a location separated from said area of skin; (e) a second electrode in electrical communication with the second reservoir; (f) means for creating an electric voltage difference between the first and second electrodes; and (g) a rate controlling membrane interposed between said first reservoir and said area of skin, said membrane being substantially impermeable to the drug when the voltage difference is absent and permeable to the drug when the voltage difference is present. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A method of administering a drug iontophoretically through a predetermined area of the skin of a patient comprising:
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placing a first reservoir comprising the drug in communication with said area of skin, said first reservoir having a first electrode in electrical communication therewith; placing a second reservoir containing an electrolyte in communication with the skin at a location separated from said area, said second reservoir having a second electrode in electrical communication therewith; and creating a voltage difference between the first and second electrodes, wherein a skin permeability enhancer is applied to said area of skin to make the skin substantially permeable to the drug and a rate controlling membrane is interposed between the reservoir and the area of skin, the membrane being substantially impermeable to the dug in the absence of the voltage difference and permeable to the drug in the presence of the voltage difference. - View Dependent Claims (13, 14, 15, 16, 17)
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Specification