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Membrane for electrotransport transdermal drug delivery

  • US 5,322,502 A
  • Filed: 01/13/1993
  • Issued: 06/21/1994
  • Est. Priority Date: 10/03/1988
  • Status: Expired due to Term
First Claim
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1. A device for administering a drug iontophoretically through a predetermined area of skin in a therapeutically effective regimen comprising:

  • (a) a first reservoir of said drug in a form susceptible to iontophoretic administration in communication with said area of skin;

    (b) a skin permeability enhancer contained within said first reservoir;

    (c) a first electrode in electrical communication with said first reservoir;

    (d) a second reservoir containing a electrolyte in communication with the skin at a location separated from said area of skin;

    (e) a second electrode in electrical communication with the second reservoir;

    (f) means for creating an electric voltage difference between the first and second electrodes; and

    (g) a rate controlling membrane interposed between said first reservoir and said area of skin, said membrane being substantially impermeable to the drug when the voltage difference is absent and permeable to the drug when the voltage difference is present.

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