Observation cell and mixing chamber
First Claim
1. A method of forming a flowing film, wherein the film flows from an upstream position adjacent a primary applicator through a film forming chamber to a downstream position adjacent a drain port of said chamber, said method comprising, in order:
- providing two elongated, opposed film supports spaced from a sidewall defining said chamber and spaced from each other to define a gap therebetween along opposed extended longitudinal edges thereof;
applying a vacuum to a drain port located adjacent to the gap;
initiating a feeding of a first liquid to the gap through a secondary applicator which is positioned adjacent to the gap at a distance from the drain port so that the liquid is supported as a film between the edges of the supports and flows along both edges toward the drain port; and
initiating a feeding of a second liquid that may be the same as or different from the first liquid to the gap through a primary applicator which is positioned adjacent to the gap at a location that is farther distant from the drain port than is the secondary applicator, the second liquid from the primary applicator establishing a film which flows between the supports toward the drain port and to which film is added liquid from the secondary applicator.
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Accused Products
Abstract
A device for detecting substances in a liquid film by measuring chemiluminescence, fluorescence or absorption using techniques such as flow-injection analysis schemes, liquid chromatographies, and gas chromatographies. The device can be used as a micro-volume mixing or reaction substrate for a variety of measurements. The device comprises at least two film supports that are separated by a small gap. One or more applicators are positioned along the gap to supply fluids to the gap. The applicators are positioned near the gap at a spacing that is near the necking length of the fluid supplied by the applicator. A thin, continuous film of the mixture of fluids to be examined is supported in the gap between the film supports. The film extends through the examining chamber and through drop and overflow detection probes. Also disclosed is a mixing or reaction chamber which comprises an enclosable mainframe into which a plurality of applicators are butted near a gap defined between two film supports. The chamber communicates with an inlet port and an exit port for controlling the pressure and other aspects of the environment in the chamber.
70 Citations
14 Claims
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1. A method of forming a flowing film, wherein the film flows from an upstream position adjacent a primary applicator through a film forming chamber to a downstream position adjacent a drain port of said chamber, said method comprising, in order:
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providing two elongated, opposed film supports spaced from a sidewall defining said chamber and spaced from each other to define a gap therebetween along opposed extended longitudinal edges thereof; applying a vacuum to a drain port located adjacent to the gap; initiating a feeding of a first liquid to the gap through a secondary applicator which is positioned adjacent to the gap at a distance from the drain port so that the liquid is supported as a film between the edges of the supports and flows along both edges toward the drain port; and initiating a feeding of a second liquid that may be the same as or different from the first liquid to the gap through a primary applicator which is positioned adjacent to the gap at a location that is farther distant from the drain port than is the secondary applicator, the second liquid from the primary applicator establishing a film which flows between the supports toward the drain port and to which film is added liquid from the secondary applicator. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A method of rapidly mixing multiple reagents in a film forming chamber, the method comprising:
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providing two elongated, opposed film supports spaced from a sidewall defining said chamber and spaced from each other to define a gap therebetween along opposed extended longitudinal edges thereof, each edge having an upstream end and a downstream end; feeding a first liquid to the gap through a primary applicator which is positioned adjacent to the gap such that the feeding of the first liquid from the primary applicator provides a laminar flow film which is supported between the edges flows as a stream along both edges toward the downstream end of both edges; and feeding a second liquid to the gap through a secondary applicator which is positioned adjacent to the gap at such a location that a jet stream of the second liquid intercepts and combines with the laminar flow film.
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9. A method of forming a flowing film, wherein the film flows from an upstream position adjacent a primary applicator through a film forming chamber to a downstream position adjacent a drain port of said chamber, comprising, in order:
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providing two elongated, opposed cell wires spaced from a sidewall defining said chamber, the cell wires defining a gap therebetween along opposed longitudinal edges thereof, the cell wires being supported on a frame comprising (a) an upper body plate defining cell holes which extend from a bottom of a upper body plate to a top of the upper body plate and into which the cell wires extend, and (b) a lower body plate defining cell holes which extend from a top of the lower body plate to a bottom of the lower body plate and into which the cell wires extend; applying a vacuum to a drain port located adjacent to the gap; initiating a feeding of a first liquid to the gap through a secondary applicator which is positioned adjacent to the gap at a distance from the drain port so that the liquid flows as a film between the cell wires toward the drain port; and initiating a feeding of a second liquid that may be the same as or different from the first liquid to the gap through a primary applicator which is positioned adjacent to the gap at a location that is farther distant from the drain port than is the secondary applicator, the second liquid from the primary applicator establishing a film which flows between the cell wires toward the drain port and to which film is added liquid from the secondary applicator. - View Dependent Claims (10, 11, 12, 13, 14)
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Specification