Coated implantable stimulation electrode and lead

• US 5,324,324 A
• Filed: 10/13/1992
• Issued: 06/28/1994
• Est. Priority Date: 10/13/1992
• Status: Expired due to Term

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Siemens Pacesetter, Inc. (Abbott Laboratories Incorporated)
• Inventors: Helland, John R., Vachon, David J.
• Primary Examiner(s): Cohen, Lee S.
• Assistant Examiner(s): Jastrzab, Jeffrey R.
• Application Number:
  US07/960,670
• Time in Patent Office: 623 Days
• Field of Search: 607/119, 607/120, 607/121, 607/122, 128/642
• US Class Current: 607/120
• CPC Class Codes: A61N 1/056 Transvascular endocardial electrode systems

Abstract

An implantable stimulation lead having an anti-inflammatory coating on the exposed surface area of the distal tip electrode. The coating is a semi-viscous or gelatinous material having the ability to absorb physiological fluids to provide electrical conductivity through the coating. The coating preferably has a matrix having an innate hypo-inflammatory property which can be combined with drugs and therapeutic agents to deliver the drugs and agents by co-dissolution or diffusion, or alternatively the matrix material can be used as a coating to keep the electrode surface electrochemically clean prior to and during implant.

Claims

1. An implantable stimulation lead adapted for electrical contact with heart tissue, said stimulation lead for use with a cardiac pulse generator, comprising:

an electrical conductor having a proximal end and a distal end;

an insulation sheath covering said conductor;

an electrode coupled to said distal end of said conductor for making electrical contact with heart tissue; and

coating means coating said electrode for reducing inflammation of the heart tissue upon implant of the stimulation lead, said coating means including a viscous material coating, wherein said viscous material coating is a composition including a therapeutic agent and a biocompatible, matrix material comprising crosslinked proteins, wherein said proteins are selected from the group consisting of albumin, collagen and gelatin.

2. The implantable stimulation lead of claim 1, wherein said crosslinked proteins comprise proteins crosslinked with 1-ethyl-3-(3-dimethylaminopropyl) -carbodiimide hydrochloride.

3. An implantable stimulation lead adapted for electrical contact with heart tissue, said stimulation lead for use with a cardiac pulse generator, comprising:

an electrical conductor having a proximal end and a distal end;

an insulation sheath covering said conductor;

an electrode coupled to said distal end of said conductor for making electrical contact with heart tissue; and

coating means coating said electrode for reducing inflammation of the heart tissue upon implant of the stimulation lead, said coating means including a viscous material coating, wherein said viscous material coating is a composition including a therapeutic agent and a biocompatible, matrix material comprising a soluble starch selected from the group consisting of amylodextrin and amylogen.

4. An implantable stimulation lead adapted for electrical contact with heart tissue, said stimulation lead for use with a cardiac pulse generator, comprising:

an electrical conductor having a proximal end and a distal end;

an insulation sheath covering said conductor;

an electrode coupled to said distal end of said conductor for making electrical contact with heart tissue; and

coating means coating said electrode for reducing inflammation of the heart tissue upon implant of the stimulation lead, said coating means including a viscous material coating, wherein said viscous material coating is a biocompatible, matrix material comprising hydrophilic polymer derivatives selected from the group consisting of polyethylene glycols, polyvinylpyrrolidones, polyacrylamide, and polyvinylalcohol, wherein said hydrophilic polymer derivatives are modified to incorporate a photo-activated crosslinking moiety.

5. An implantable stimulation lead adapted for electrical contact with heart tissue, said stimulation lead for use with a cardiac pulse generator, comprising:

an electrical conductor having a proximal end and a distal end;

an insulation sheath covering said conductor;

an electrode coupled to said distal end of said conductor for making electrical contact with heart tissue; and

coating means coating said electrode for reducing inflammation of the heart tissue upon implant of the stimulation lead, said coating means including a viscous material coating, wherein said viscous material coating is a biocompatible, matrix material comprising hydrophilic polymer derivatives selected from the group consisting of polyethylene glycols, polyvinylpyrrolidones, polyacrylamide, and polyvinylalcohol, wherein said hydrophilic polymer derivatives are modified to incorporate a thermally-activated crosslinking moiety.