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Multiplexed fluorescence detector system for capillary electrophoresis

  • US 5,324,401 A
  • Filed: 02/05/1993
  • Issued: 06/28/1994
  • Est. Priority Date: 02/05/1993
  • Status: Expired due to Term
First Claim
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1. A multiplexed fluorescence detection system for use with capillary electrophoresis to detect target species in a sample, comprising:

  • (a) an array of at least two capillaries each having an intake end, an outflow end, and an annular wall wherein at least a portion of the wall is translucent to light having a wavelength of about 200-1,500 nm, the intake end being in fluid communication with the sample so that the sample is drawn into the capillary;

    (b) an array of at least two optical fibers, each optical fiber having a first and second end, the second end of each optical fiber being coupled to a capillary in the array of capillaries;

    (c) means for generating coherent light positioned to direct the coherent light onto the first end of the optical fibers, wherein the coherent light is of a wavelength suitable to cause fluorescence in target species present in the capillaries; and

    (d) means for substantially simultaneously detecting changes in fluorescent emission by the target species through the annular wall of each capillary.

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