Implantable structure for containing substances for delivery to a body
First Claim
1. Implantable structure for incorporation into the body tissues of an animal to provide administration of substances from said implantable structure to said body tissues comprising:
- an outer member of porous synthetic material, the pores of said synthetic material being sized from about 60 microns to about 500 microns to provide ingrowth of vascularized connective tissue therethrough to effect incorporation of said implantable structure into said body tissues;
an inner member of selectively permeable porous material positioned within said outer member and structured to provide immunoisolation to substances containable within said inner member, the pores of said selectively permeable material being sized to provide movement of macromolecules therethrough while preventing ingrowth of tissue therethrough and having a pore size of from about 30,000 Daltons to about 25 microns;
an inner space formed within said inner member for placement of substances therein; and
port means associated with said outer member and said inner member, said port means being in communication with said inner space to transport said substances to and from said inner space.
1 Assignment
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Accused Products
Abstract
An implantable structure for incorporation into the tissues of a body is provided which retains therein fluid substances or biological substances which produce, or cause to be produced, biochemicals deliverable to the body. The implantable structure is configured to provide insertion and removal of substances therefrom as needed. The implantable structure generally comprises a porous outer member configured to encourage ingrowth of vascularized tissue therethrough, and an inner member of selectively permeable material providing interior space for inserting substances therein and which is structured to prevent ingrowth of tissue therethrough. The inner member is capable of providing immunoisolation to the substances therein as required.
142 Citations
10 Claims
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1. Implantable structure for incorporation into the body tissues of an animal to provide administration of substances from said implantable structure to said body tissues comprising:
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an outer member of porous synthetic material, the pores of said synthetic material being sized from about 60 microns to about 500 microns to provide ingrowth of vascularized connective tissue therethrough to effect incorporation of said implantable structure into said body tissues; an inner member of selectively permeable porous material positioned within said outer member and structured to provide immunoisolation to substances containable within said inner member, the pores of said selectively permeable material being sized to provide movement of macromolecules therethrough while preventing ingrowth of tissue therethrough and having a pore size of from about 30,000 Daltons to about 25 microns; an inner space formed within said inner member for placement of substances therein; and port means associated with said outer member and said inner member, said port means being in communication with said inner space to transport said substances to and from said inner space. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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Specification