Systems for transdermal administration of medicaments
First Claim
1. In a non-adhesive matrix for use as a dosage form in the transdermal administration of a medicament to a mammal which comprises a porous, non-adhesive, absorbent perforate solid support having absorbed thereon a mixture comprising a medicament adapted for transdermal administration and a pharmaceutically acceptable carrier for the medicament, the improvement being that the carrier consists essentially of at least one compound selected from the group consisting of esters of C8-24 fatty acids with at least one aliphatic hydroxy compound containing 2-12 carbon atoms and 2-3 hydroxy groups;
- andthe acid component of the ester is selected from the group consisting of caprylic, capric, lauric, palmic, stearic, arachidic, behenic, lignoceric, oleic, elaidic, petroselinic, linoleic, alpha-linolenic, gamma-linolenic, linolelaidic, arachidic, 11-eicosenoic, 11,14-eicosadienoic, 11,14,17-eicosatrienoic, 8,11,14-eicosatrienoic, arachidonic, 5,8,11,14,17-eicosapentaenoic, erucic and nervonic acids;
provided that when said hydroxy compound is glycerol the esters thereof are selected from diglycerides and triglycerides of at least one C8-24 fatty acid,whereby said medicament is detectable in the bloodstream within two hours after administration thereof.
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Accused Products
Abstract
A non-adhesive matrix for use as a dosage form in the transdermal administration of a medicament to a mammal comprises a porous, non-adhesive, absorbent perforate solid support having absorbed thereon a mixture comprising a medicament adapted for transdermal administration and a pharmaceutically acceptable carrier for the medicament. The carrier consists essentially of at least one compound selected from esters of C8-24 fatty acids, pharmaceutically acceptable aliphatic polyhydroxy compounds and non-volatile paraffins.
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Citations
4 Claims
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1. In a non-adhesive matrix for use as a dosage form in the transdermal administration of a medicament to a mammal which comprises a porous, non-adhesive, absorbent perforate solid support having absorbed thereon a mixture comprising a medicament adapted for transdermal administration and a pharmaceutically acceptable carrier for the medicament, the improvement being that the carrier consists essentially of at least one compound selected from the group consisting of esters of C8-24 fatty acids with at least one aliphatic hydroxy compound containing 2-12 carbon atoms and 2-3 hydroxy groups;
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the acid component of the ester is selected from the group consisting of caprylic, capric, lauric, palmic, stearic, arachidic, behenic, lignoceric, oleic, elaidic, petroselinic, linoleic, alpha-linolenic, gamma-linolenic, linolelaidic, arachidic, 11-eicosenoic, 11,14-eicosadienoic, 11,14,17-eicosatrienoic, 8,11,14-eicosatrienoic, arachidonic, 5,8,11,14,17-eicosapentaenoic, erucic and nervonic acids; provided that when said hydroxy compound is glycerol the esters thereof are selected from diglycerides and triglycerides of at least one C8-24 fatty acid, whereby said medicament is detectable in the bloodstream within two hours after administration thereof. - View Dependent Claims (2, 3, 4)
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Specification