Calibration medium containment system
First Claim
Patent Images
1. A self-contained self-calibrating disposable cartridge for the analysis of liquid samples insertable for use with an associated diagnostic instrument comprising:
- (a) an enclosure containing a dual-function chamber for calibration media storage and fluid sample analysis, said dual-function chamber defining a hollow interior and inlet and outlet accesses;
(b) an array of electrochemical sensors including sensor electrodes in communication with the interior of the dual-function chamber;
(c) an amount of at least one compatible calibration material for one or more of the electrochemical sensors predisposed and stored in the dual-function chamber in contact with said one or more of the electrochemical sensors for immediate availability for the cailbration thereof, said calibration material further being of a type displaced by the introduction of a liquid sample to be analyzed to prevent cross-contamination; and
(d) a plurality of conductors connected to the sensor electrodes for connecting the sensor electrodes to calibration and analysis devices outside the cartridge.
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Abstract
A method and apparatus which contemplates coverage control, and collateral containment of calibration media with respect to diverse electrodes in a flow-through calibration and measurement cell during storage and sensor calibration and in which the calibration media are displaced by the entry of a subsequent sample to be tested. The system is associated with a disposable cartridge insertable into a portable instrument that contains all of the electronics and other end support equipment associated with automated calibration and sample measurement.
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Citations
17 Claims
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1. A self-contained self-calibrating disposable cartridge for the analysis of liquid samples insertable for use with an associated diagnostic instrument comprising:
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(a) an enclosure containing a dual-function chamber for calibration media storage and fluid sample analysis, said dual-function chamber defining a hollow interior and inlet and outlet accesses; (b) an array of electrochemical sensors including sensor electrodes in communication with the interior of the dual-function chamber; (c) an amount of at least one compatible calibration material for one or more of the electrochemical sensors predisposed and stored in the dual-function chamber in contact with said one or more of the electrochemical sensors for immediate availability for the cailbration thereof, said calibration material further being of a type displaced by the introduction of a liquid sample to be analyzed to prevent cross-contamination; and (d) a plurality of conductors connected to the sensor electrodes for connecting the sensor electrodes to calibration and analysis devices outside the cartridge. - View Dependent Claims (2, 3, 4, 5)
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6. A self-contained self-calibrating disposable cartridge for the analysis of liquid samples insertable for use with an associated diagnostic instrument comprising:
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(a) an enclosure containing a dual-function chamber for calibration media storage and fluid sample analysis, said dual-function chamber defining a hollow interior and inlet and outlet accesses; (b) an array of electrochemical sensors including sensor electrodes in communication with the interior of the dual-function chamber; (c) an amount of at least one compatible calibration material for one or more of the electrochemical sensors predisposed and stored in the dual-function chamber in contact with said one or more of the electrochemical sensors for immediate availability for the calibration thereof, said calibration material further being of a type displaced by the introduction of a liquid sample to be analyzed to prevent cross-contamination; (d) a plurality of conductors connected to the sensor electrodes for connecting the sensor electrodes to calibration and analysis devices outside the cartridge; (e) enclosed hollow waste chamber in flow passage communication with the outlet access of the dual-function chamber and having sufficient capacity to contain displaced calibration material and excess sample material; and (f) sample access port for receiving a liquid sample to be analyzed in the dual-function chamber in fluid passage communication with the inlet access of the dual-function chamber. - View Dependent Claims (7, 8, 9, 10, 11, 12, 13, 14)
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15. A self-contained self-calibrating disposable cartridge for the analysis of liquid samples insertable for use with an associated diagnostic instrument comprising:
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(a) an enclosure containing a dual-function chamber for calibration media storage and fluid sample analysis, said dual-function chamber defining a hollow interior and inlet and outlet accesses; (b) an array of electrochemical sensors including sensor electrodes in communication with the interior of the dual-function chamber; (c) an amount of a plurality of compatible calibration materials for one or more of the electrochemical sensors predisposed and stored in the dual-function chamber each calibration material being in contact with one or more of the electrochemical sensors for immediate availability for the calibration thereof; and (d) enclosed hollow waste chamber in flow passage communication with the outlet access of the dual-function chamber and having sufficient capacity to contain the calibration material and excess sample material; (e) sample access port for receiving a liquid sample to be analyzed in the dual-function chamber in fluid passage communication with the inlet access of the dual-function chamber; (f) wherein the introduction of a liquid sample into the dual function chamber produces displacement of the calibration materials to the hollow waste chamber such that the liquid sample material replaces the calibration material as material in contact with the electrochemical sensors in the dual-function chamber; and (g) a plurality of conductors connected to the sensor electrodes for connecting the sensor electrodes to calibration and analysis devices outside the cartridge. - View Dependent Claims (16, 17)
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Specification