Calibration medium containment system

• US 5,325,853 A
• Filed: 09/02/1992
• Issued: 07/05/1994
• Est. Priority Date: 09/02/1992
• Status: Expired due to Term

• Current Assignee: Easydx Inc.
• Original Assignee: Diametrics Medical, Inc. (Allegro Biodiesel Corp.)
• Inventors: Morris, Russell L., Deetz, David W.
• Primary Examiner(s): Cohen, Lee S.
• Assistant Examiner(s): GILBERT, SAMUEL G
• Application Number:
  US07/940,271
• Time in Patent Office: 671 Days
• Field of Search: 128/630, 128/632, 128/635, 128/637, 128/760, 128/912, 204/403, 204/415, 204/416, 204/418, 204/419, 204/153.17
• US Class Current: 204/403.02
• CPC Class Codes: G01N 27/4165 for pH meters

Abstract

A method and apparatus which contemplates coverage control, and collateral containment of calibration media with respect to diverse electrodes in a flow-through calibration and measurement cell during storage and sensor calibration and in which the calibration media are displaced by the entry of a subsequent sample to be tested. The system is associated with a disposable cartridge insertable into a portable instrument that contains all of the electronics and other end support equipment associated with automated calibration and sample measurement.

Claims

1. A self-contained self-calibrating disposable cartridge for the analysis of liquid samples insertable for use with an associated diagnostic instrument comprising:

(a) an enclosure containing a dual-function chamber for calibration media storage and fluid sample analysis, said dual-function chamber defining a hollow interior and inlet and outlet accesses;

(b) an array of electrochemical sensors including sensor electrodes in communication with the interior of the dual-function chamber;

(c) an amount of at least one compatible calibration material for one or more of the electrochemical sensors predisposed and stored in the dual-function chamber in contact with said one or more of the electrochemical sensors for immediate availability for the cailbration thereof, said calibration material further being of a type displaced by the introduction of a liquid sample to be analyzed to prevent cross-contamination; and

(d) a plurality of conductors connected to the sensor electrodes for connecting the sensor electrodes to calibration and analysis devices outside the cartridge.

2. The cartridge of claim 1, wherein the calibration material is selected from a group consisting of gels and stabilized dispersions of calibration materials.

3. The cartridge of claim 2 wherein the calibration material is applied to one or more of the sensors in film form.

4. The cartridge of claim 1 further comprising flow restriction means in the inlet and outlet accesses of the dual-function chamber to prevent loss of the calibration material from the chamber prior to displacement by a liquid sample.

5. The cartridge of claim 4 wherein the calibration material is a viscous liquid.

6. A self-contained self-calibrating disposable cartridge for the analysis of liquid samples insertable for use with an associated diagnostic instrument comprising:

(a) an enclosure containing a dual-function chamber for calibration media storage and fluid sample analysis, said dual-function chamber defining a hollow interior and inlet and outlet accesses;

(b) an array of electrochemical sensors including sensor electrodes in communication with the interior of the dual-function chamber;

(c) an amount of at least one compatible calibration material for one or more of the electrochemical sensors predisposed and stored in the dual-function chamber in contact with said one or more of the electrochemical sensors for immediate availability for the calibration thereof, said calibration material further being of a type displaced by the introduction of a liquid sample to be analyzed to prevent cross-contamination;

(d) a plurality of conductors connected to the sensor electrodes for connecting the sensor electrodes to calibration and analysis devices outside the cartridge;

(e) enclosed hollow waste chamber in flow passage communication with the outlet access of the dual-function chamber and having sufficient capacity to contain displaced calibration material and excess sample material; and

(f) sample access port for receiving a liquid sample to be analyzed in the dual-function chamber in fluid passage communication with the inlet access of the dual-function chamber.

7. The cartridge of claim 6 wherein the calibration material is selected from a group consisting of gels and stabilized dispersions of calibration materials.

8. The cartridge of claim 7 wherein the calibration material is applied to one or more of the sensors in film form.

9. The cartridge of claim 7 wherein the selected gel is a liquid at normal operating temperature.

10. The cartridge of claim 7 wherein the electrochemical sensors include at least reference, pH, CO₂ and O₂ electrodes.

11. The cartridge of claim 7 wherein the electrodes include a K⁺ electrode.

12. The cartridge of claim 11 wherein the calibration materials are selected from the group consisting of gels and stabilized dispersions of calibration materials.

13. The cartridge of claim 6 further comprising flow restriction means in the inlet and outlet accesses of the dual-function chamber to prevent loss of the calibration material from the chamber prior to displacement by a liquid sample.

14. The cartridge of claim 13 wherein the calibration material is a viscous liquid.

15. A self-contained self-calibrating disposable cartridge for the analysis of liquid samples insertable for use with an associated diagnostic instrument comprising:

(a) an enclosure containing a dual-function chamber for calibration media storage and fluid sample analysis, said dual-function chamber defining a hollow interior and inlet and outlet accesses;

(b) an array of electrochemical sensors including sensor electrodes in communication with the interior of the dual-function chamber;

(c) an amount of a plurality of compatible calibration materials for one or more of the electrochemical sensors predisposed and stored in the dual-function chamber each calibration material being in contact with one or more of the electrochemical sensors for immediate availability for the calibration thereof; and

(d) enclosed hollow waste chamber in flow passage communication with the outlet access of the dual-function chamber and having sufficient capacity to contain the calibration material and excess sample material;

(e) sample access port for receiving a liquid sample to be analyzed in the dual-function chamber in fluid passage communication with the inlet access of the dual-function chamber;

(f) wherein the introduction of a liquid sample into the dual function chamber produces displacement of the calibration materials to the hollow waste chamber such that the liquid sample material replaces the calibration material as material in contact with the electrochemical sensors in the dual-function chamber; and

(g) a plurality of conductors connected to the sensor electrodes for connecting the sensor electrodes to calibration and analysis devices outside the cartridge.

16. The cartridge of claim 15 wherein at least one of the calibration materials is a viscous liquid.

17. The cartridge of claim 16 further comprising flow restriction means in the inlet and outlet accesses of the dual-function chamber to prevent loss of the calibration material from the chamber prior to displacement by a liquid sample.