Device for withdrawing body fluids

• US 5,325,867 A
• Filed: 01/24/1992
• Issued: 07/05/1994
• Est. Priority Date: 06/01/1990
• Status: Expired due to Fees

• Current Assignee: Avl Medical Instruments AG (Roche Holding AG)
• Original Assignee: Avl Medical Instruments AG (Roche Holding AG)
• Inventors: Skrabal, Falko, Kleinhappl, Erich, List, Helmut
• Primary Examiner(s): Pellegrino, Stephen C.
• Assistant Examiner(s): Tucker, Guy V.
• Application Number:
  US07/820,591
• Time in Patent Office: 893 Days
• Field of Search: 128/760, 128/762, 128/763, 128/764, 128/765, 128/766, 128/767, 128/771, 604/27, 604/36, 604/37, 604/38, 604/39, 604/43, 604/44, 604/48, 604/65, 604/67, 604/113, 604/114, 604/131, 604/132, 604/133, 604/149, 604/151, 604/153, 604/51, 604/52, 604/53, 604/19 , 604/152
• US Class Current: 600/578
• CPC Class Codes: A61B 5/15003 for venous or arterial blood
• CPC Class Codes: A61B 5/150229 Pumps for assisting the blood sampling
• CPC Class Codes: A61B 5/155 Devices specially adapted for continuous or multiple sampling, e.g. at predetermined intervals devices loaded with multiple lancets simultaneously A61B5/15146
• CPC Class Codes: G01N 2035/00445 Other cooling arrangements
• CPC Class Codes: G01N 35/025 having a carousel or turntable for reaction cells or cuvettes
• CPC Class Codes: G01N 35/1079 with means for piercing stoppers or septums

Abstract

A device for the sampling of body fluids using a hollow needle (6), is provided with a storage system (3) with several separate sample containers (4) placed on a movable carrier (9). The containers (4) which are sealed by puncturable membranes (5) so as to be gas-tight, will receive collected fractions of the body fluid at given intervals, a device (7) connected to a control unit (2) being provided, by which the hollow needle (6) is positioned over each sample container (4) in turn and is inserted through the membrane (5) into the sample container. The sampling device 1 is configured as a two-channel cannula (18), one (19) of whose channels is connected via a first connecting tube (25) to the hollow needle (6) used for insertion into the sample containers (4), while its other channel (20) is connected via a second connecting tube (26) to a pump (8'"'"'; 21) operated by the control unit (2). In their unused state the individual sample containers (4) are filled within an amount of gas or gas mixture whose volume at atmospheric pressure is smaller than that of the body fluid to be received.

Claims

1. A device for withdrawing body fluids, such as blood, urine and tissue fluid, comprising a sampling unit connected to a hollow needle, and a storage system comprising a heat-insulating housing having openings through which said hollow needle may pass, wherein said heat-insulating housing encases several separate sample containers placed on a movable carrier, each said sample container being sealed by means of a puncturable membrane so as to be gas-tight, said sample containers intended to receive fractions of said body fluid collected at given intervals, said device also comprising a control unit being provided to control the positioning of said hollow needle over each of said sample containers in turn and to control the insertion of said hollow needle into each sample container through said puncturable membrane, wherein said sampling unit is configured as a two-channel cannula, a first of said channels being connected via a first connecting tube to said hollow needle and a second of said channels being connected via a second connecting tube to a pump operated by said control unit, and wherein said sample containers have rigid walls, and wherein the pressure prevailing inside said sample containers is lower than the ambient pressure.

2. A device according to claim 1, wherein said first connecting tube between said two-channel cannula and said hollow needle is provided with a metering unit.

3. A device according to claim 1, wherein said first connecting tube between said two-channel cannula and said hollow needle is provided with a pump.

4. A device according to claim 1, wherein said heatinsulating housing contains a cooling medium and a temperature sensor connected to said control unit.

5. A device according to claim 1, wherein said heat-insulating housing including said sample containers is detachable from said sampling unit and said hollow needle.

6. A device according to claim 1, wherein said pump connected to said second channel of said two-channel cannula is a drug pump including a drive is connected to said control unit.

7. A device according to claim 6, comprising an additional drug pump having a drive which is connected to said control unit.

8. A device according to claim 1, wherein said pump is a peristaltic pump, wherein said second connecting tube is connected to a container for a perfusion fluid, and wherein said first connecting tube is passed through said peristaltic pump in a direction of suction, and said second connecting tube is passed through said peristaltic pump in a pumping direction.

9. A device according to claim 8, wherein the wall of said first channel of said two-channel cannula is configured, at least in part, as a diffusion path.

10. A device according to claim 8, wherein the wall of said first channel of said two-channel cannula has a number of perforations.

11. A device for withdrawing body fluids, such as blood, urine and tissue fluid, comprising a sampling unit connected to a hollow needle, and a storage system comprising a heat-insulating housing having openings through which said hollow needle may pass, wherein said heat-insulating housing encases several separate sample containers placed on a movable carrier, each said sample container being sealed by means of a puncturable membrane so as to be gas-tight, said sample containers intended to receive fractions of said body fluid collected at given intervals, said device also comprising a control unit being provided to control the positioning of said hollow needle over each of said sample containers in turn and to control the insertion of said hollow needle into each sample container through said puncturable membrane, wherein said sampling unit is configured as a two-channel cannula, a first of said channels being connected via a first connecting tube to said hollow needle and a second of said channels being connected via a second connecting tube to a pump operated by said control unit, and wherein each said sample container comprises an evacuated deformable vessel.

12. A device according to claim 11, wherein said first connecting tube between said two-channel cannula and said hollow needle is provided with a metering unit.

13. A device according to claim 11, wherein said first connecting tube between said two-channel cannula and said hollow needle is provided with a pump.

14. A device according to claim 11, wherein said heat-insulating housing contains a cooling medium and a temperature sensor connected to said control unit.

15. A device according to claim 14, wherein said heat-insulating housing including said sample containers is detachable from said sampling unit and said hollow needle.

16. A device according to claim 11, wherein said pump connected to said second channel of said two-channel cannula is a drug pump including a which drive is connected to said control unit.

17. A device according to claim 16, comprising an additional drug pump having a drive which is connected to said control unit.

18. A device according to claim 11, wherein said pump is a peristaltic pump, wherein said second connecting tube is connected to a container for a perfusion fluid, and wherein said first connecting tube is passed through said peristaltic pump in a direction of suction, and said second connecting tube is passed through said peristaltic pump in a pumping direction.

19. A device according to claim 18, wherein the wall of said first channel of said two-channel cannula is configured, at least in part, as a diffusion path.

20. A device according to claim 18, wherein the wall of said first channel of said two-channel cannula has a number of perforations.