Biocompatible perforated membranes, processes for their preparation, their use as a support in the in vitro growth of epithelial cells, the artificial skin obtained in this manner, and its use in skin grafts
First Claim
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1. Biocompatible membranes consisting of materials of natural, synthetic or semisynthetic original, and having a thickness of between 10 and 500μ
- , which comprise an ordered series of holes of a defined and constant size between 10 and 1000μ
, separated from each other by a constant distance of between 50 and 1000μ
, said membrane enabling in vitro culture of keratinocytes within the holes and on both sides of said membrane.
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Abstract
It is provided biocompatible membranes constructed of materials of natural, synthetic or semisynthetic origin, and having a thickness of between 10 and 500μ, characterised by containing an ordered series of holes of a constant size between 10 and 1000μ, separated from each other by a constant distance of between 50 and 1000μ, and obtained by perforation by mechanical, thermal laser or ultraviolet radiation means, they being suitable for use as a support for the in vitro growth of epithelial cells. Artificial skins obtained thereby and its use in grafts are also provided.
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Citations
20 Claims
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1. Biocompatible membranes consisting of materials of natural, synthetic or semisynthetic original, and having a thickness of between 10 and 500μ
- , which comprise an ordered series of holes of a defined and constant size between 10 and 1000μ
, separated from each other by a constant distance of between 50 and 1000μ
, said membrane enabling in vitro culture of keratinocytes within the holes and on both sides of said membrane. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
- , which comprise an ordered series of holes of a defined and constant size between 10 and 1000μ
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12. Artificial skin composed of a biocompatible support membrane consisting of materials of natural, synthetic or semisynthetic origin, and having a thickness of between 10 and 500μ
- , which contains an ordered series of holes of a defined and constant size between 10 and 1000μ
, separated from each other by a constant distance of between 50 and 1000μ
, together with autologous or heterologous keratinocyte microcolonies in the active proliferation stage present within said holes and on both sides of said membrane. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20)
- , which contains an ordered series of holes of a defined and constant size between 10 and 1000μ
Specification