Method of tissue-specific delivery

• US 5,326,568 A
• Filed: 04/30/1992
• Issued: 07/05/1994
• Est. Priority Date: 05/03/1991
• Status: Expired due to Fees

• Current Assignee: Vincent C. Giampapa
• Original Assignee: Tomagen Technologies, Inc.
• Inventors: Giampapa, Vincent C.
• Primary Examiner(s): Page, Thurman K.
• Assistant Examiner(s): AZPURU, CARLOS A
• Application Number:
  US07/876,783
• Time in Patent Office: 796 Days
• Field of Search: 424/422, 424/423, 424/424, 424/426, 604/890.1, 604/892.1, 623/11
• US Class Current: 424/426
• CPC Class Codes: A61K 9/0024 Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L
• CPC Class Codes: A61M 31/002 Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50
• CPC Class Codes: Y10S 623/915 Method or apparatus for preparing biological material
• CPC Class Codes: Y10S 707/942 Legal/academic
• CPC Class Codes: Y10S 707/99934 Query formulation, input preparation, or translation

Abstract

The method of tissue-specific delivery of therapeutic agents via a bio-oncotic pump which includes the steps of furnishing an implantable element which is biodegradable in situ within human tissue. Such an element defines a series of respective concentric shells having different therapeutic agents disposed upon each of the shells such that the outermost shell and associated agents will be delivered earliest, while the innermost shell and its agents will be delivered last. The material of the biodegradable element is selected from the group of materials including processed sheep dermal collagen, Hench'"'"'s bioglass, fibrinogen, polyimino-carbonate, and polylactic acid. A vaso-inductive agent is integrated into the surface of the element. Selected groups of therapeutic agents are incorporated into the element, which is followed by the subcutaneous implantation and securing of said element into the human tissue at the site of interest. Following implantation of the element, the vaso-inductive agent will stimulate capillary growth to facilitate delivery of the therapeutic agent to the tissue specific site.

Claims

1. A method of bio-oncotic tissue-specific delivery of therapeutic agents, comprising the steps of:

(a) furnishing an implantable element that is biodegradable in situ within human tissue, said implantable element defining a series of respectively concentric shells having said therapeutic agents incorporated upon or within each of said shells such that the outermost shell and said agents associated therewith will be delivered earliest while the innermost shell and its agents will be delivered last within said human tissue, said agents to be delivered selected from the group consisting essentially of chemotherapeutics, analgesics, hormones, enzymes, anesthetics, anti-inflammatories, antibiotics, and immunoglobulins, and the material of said biodegradable element selected from the group consisting essentially of processed sheep dermal collagen, Hench'"'"'s bioglass, fibrinogen, polyimino-carbonates, and polylactic acid;

(b) integrating into a surface of said element a vaso-inductive agent selected from the group consisting essentially of vascular endothelial growth factor, platelet growth factor, vascular permeability growth factor, fibroblast growth factor, and transforming growth factor beta; and

(c) subcutaneously implanting and securing said element into said tissue,

whereby, following implantation of said element into said tissue, said vaso-inductive agent will stimulate capillary growth thereby facilitating delivery of said therapeutic agents to said tissue.

2. The method as recited in claim 1, in which said implantable element furnishing step (a) comprises:

providing a planar substrate rolled spirally upon an axis thereof to approximate the external geometry of a cylinder.

3. The method as recited in claim 1 in which said implantable element furnishing Step (a) comprises:

furnishing a series of respectively concentric shells having different therapeutic agents disposed upon each of said shells such that the outermost shell and associated agents will be delivered earliest while the innermost shell and its agents will be delivered last to the human tissue.

4. The method as recited in claim 3, further comprising the step of:

(e) providing further vasoinductive agents disposed between each of said concentric shells.

5. The method as recited in claim 3, in which said step of furnishing concentric shells comprises the step of:

furnishing concentric tubules.

6. The method as recited in claim 5, further comprising the step of:

(f) providing further vasoinductive agents disposed between each of said concentric tubules.

7. The method as recited in claim 1, in which said integrating Step (b) comprises:

use of an angiogenic agent as said vasoinductive agent.