Dosage forms comprising polymers comprising different molecular weights
First Claim
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1. A dosage form for the administration of a drug to a patient, the dosage form comprising:
- (a) a first composition comprising 10 ng to 750 mg of drug;
(b) a second composition for pushing the first composition from the dosage form;
(c) a wall surrounding the first and second compositions, said wall comprising at least in part a composition permeable to the passage of fluid; and
,(d) at least one exit means in the wall for delivering the drug from the dosage form to the patient; and
wherein said,(e) first composition comprises a carboxymethylcellulose comprising a 10,000 to 300,000 molecular weight; and
said,(f) second composition comprising a carboxymethylcellulose comprising a molecular weight greater than 300,000 to 1,200,000; and
wherein said(g) first and second compositions, when the dosage form is in operation, cooperate to deliver substantially all the drug in the dosage form to the patient over time.
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Abstract
A dosage form is disclosed comprising a wall surrounding a compartment, which comprises a first composition comprising a carboxymethylcellulose and a second composition comprising a higher molecular weight carboxymethylcellulose. The first composition comprises a dosage amount of drug that delivers from the dosage form at a controlled rate over time.
62 Citations
13 Claims
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1. A dosage form for the administration of a drug to a patient, the dosage form comprising:
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(a) a first composition comprising 10 ng to 750 mg of drug; (b) a second composition for pushing the first composition from the dosage form; (c) a wall surrounding the first and second compositions, said wall comprising at least in part a composition permeable to the passage of fluid; and
,(d) at least one exit means in the wall for delivering the drug from the dosage form to the patient; and
wherein said,(e) first composition comprises a carboxymethylcellulose comprising a 10,000 to 300,000 molecular weight; and
said,(f) second composition comprising a carboxymethylcellulose comprising a molecular weight greater than 300,000 to 1,200,000; and
wherein said(g) first and second compositions, when the dosage form is in operation, cooperate to deliver substantially all the drug in the dosage form to the patient over time. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A first composition comprising 10 ng to 750 mg of a drug and a carboxymethylcellulose comprising a 10,000 to 300,000 molecular weight;
- a second composition comprising a carboxymethylcellulose comprising a molecular weight greater than 300,000 to 1,200,000; and
wherein said first composition and second composition are in bilayer arrangement.
- a second composition comprising a carboxymethylcellulose comprising a molecular weight greater than 300,000 to 1,200,000; and
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10. A dosage form for administering drug to a patient in need of therapy wherein, the dosage form comprises:
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(a) a first composition comprising 10 ng to 750 mg of a drug, riboflavin, a surface active agent and a carboxymethylcellulose comprising a 10,000 to 300,000 molecular weight; (b) a second composition for pushing the first composition from the dosage form comprising a carboxymethylcellulose comprising a molecular weight greater than 300,000 to 1,200,000; and
,(c) at least one exit means in the wall for delivering the drug from the dosage form to the patient. - View Dependent Claims (11, 12)
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13. A first composition comprising 10 ng to 750 mg of a drug, riboflavin, a surface active agent and a carboxymethylcellulose comprising a 10,000 to 300,000 molecular weight;
- a second composition comprising a carboxymethylcellulose comprising a molecular weight greater than 300,000 to 1,200,000; and
wherein said first composition and second composition are in bilayer arrangement. X
- a second composition comprising a carboxymethylcellulose comprising a molecular weight greater than 300,000 to 1,200,000; and
Specification