Method and compositions for manufacture of chemical sensors
First Claim
1. A method of making an analyte sensor including an optical fiber having a surface portion covered with a polymeric analyte sensing matrix including a dye indicator material, comprising the steps of:
- preparing an analyte permeable polymer with an analyte sensitive indicator dye covalently bonded to the analyte permeable polymer to form a liquid polymeric analyte sensing matrix;
forming a liquid mixture of said liquid polymeric analyte sensing matrix with a crosslinking agent and a crosslinking inhibitor which can be removed by exposure to heat;
coating said optical fiber surface portion with said liquid mixture; and
heating said liquid mixture on said optical fiber surface portion for a sufficient period of time to remove said crosslinking inhibitor from said liquid mixture, whereby said crosslinking agent crosslinks said liquid polymeric analyte sensing matrix in situ on said optical fiber surface portion thereby producing a cured sensing matrix.
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Abstract
The method for making an optical fiber microsensor involves applying an uncured analyte sensing matrix to an optical fiber and crosslinking the sensing matrix in situ on the optical fiber to yield an ion permeable microsensor which can be used intravascularly to monitor pH, or partial pressures of oxygen or carbon dioxide in blood. The liquid form of the sensing matrix contains a crosslinking agent and a crosslinking inhibitor which can be removed by exposure to elevated temperatures to allow the sensing matrix to crosslink and cure as desired, in situ, on the surface of the optical fiber. A liquid crosslinking overcoat layer containing a crosslinking agent and a crosslinking inhibitor which can be removed by exposure to heat can also be applied over the cured sensing matrix.
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Citations
30 Claims
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1. A method of making an analyte sensor including an optical fiber having a surface portion covered with a polymeric analyte sensing matrix including a dye indicator material, comprising the steps of:
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preparing an analyte permeable polymer with an analyte sensitive indicator dye covalently bonded to the analyte permeable polymer to form a liquid polymeric analyte sensing matrix; forming a liquid mixture of said liquid polymeric analyte sensing matrix with a crosslinking agent and a crosslinking inhibitor which can be removed by exposure to heat; coating said optical fiber surface portion with said liquid mixture; and heating said liquid mixture on said optical fiber surface portion for a sufficient period of time to remove said crosslinking inhibitor from said liquid mixture, whereby said crosslinking agent crosslinks said liquid polymeric analyte sensing matrix in situ on said optical fiber surface portion thereby producing a cured sensing matrix. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30)
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Specification