Syringe-filling and medication mixing dispenser

• US 5,329,976 A
• Filed: 09/21/1992
• Issued: 07/19/1994
• Est. Priority Date: 12/09/1991
• Status: Expired due to Fees

• Current Assignee: Habley Medical Technology Corporation
• Original Assignee: Habley Medical Technology Corporation
• Inventors: Foster, Clark B., Smedley, William H., Haber, Terry M.
• Primary Examiner(s): JACYNA, J CASIMER
• Application Number:
  US07/948,278
• Time in Patent Office: 666 Days
• Field of Search: 141/18, 141/21, 141/25-27, 141/29, 141/46, 141/285, 141/309, 141/59, 141/35, 141/104-106, 141/329, 141/330, 141/375, 604/82, 604/86, 604/87, 604/205, 604/207-211, 604/232, 604/407, 604/411-415, 604/134-136, 604/139, 604/191, 222/135-137
• US Class Current: 141/25
• CPC Class Codes: A61J 1/201 having one piercing end
• CPC Class Codes: A61J 1/2017 having three or more piercing ends
• CPC Class Codes: A61J 1/2055 having gripping means
• CPC Class Codes: A61J 1/2058 having multiple connecting ports
• CPC Class Codes: A61J 1/2065 having aligning and guiding means
• CPC Class Codes: A61J 1/2075 for external venting
• CPC Class Codes: A61J 1/2082 for gas filtration
• CPC Class Codes: A61J 1/2089 Containers or vials which are to be joined to each other in order to mix their contents combinations of vial and syringe for mixing their contents A61J1/2096
• CPC Class Codes: A61J 1/2096 Combination of a vial and a syringe for transferring or mixing their contents

Abstract

A medication dispenser (2, 120) is used to directly fill a syringe (8, 134) with measured amounts of one or more liquid medications, typically two different types of insulin, from containers, such as vials (4, 6) and cartridges (230, 232, 234) each having a septum at one end; each cartridge has a pierceable piston (256) at the other end. The septum of each container is pierced by hollow liquid spikes (54) while hollow gas spikes (56) pierce the septum of the vial and the piston of the cartridge. Liquid is pumped out of the container and air is replaced into the container through the liquid and gas spikes. Two of the cartridges can contain a diluent (231) and a lyophilized component (233) respectively; the diluent in the first cartridge can be pumped into the second cartridge through a one-way valve to create a mixed pharmaceutical which is then pumped into the syringe, with or without another pharmaceutical.

Claims

1. A multiple medication dispenser, for use with first and second containers containing first and second liquid medications and a syringe of the type including a needle cannula, a barrel and a plunger, the dispenser comprising:

a body to which the first and second containers and the syringe are mountable;

first and second dual port means for providing first and second gas and liquid ports into the interiors of the first and second containers;

first means for substantially simultaneously pumping a first gas into the first container through the first gas port and the first liquid medication from the first container through the first liquid port;

second means for substantially simultaneously pumping a second gas into the second container through the second gas port and the second liquid medication from the second container through the second liquid port;

means for fluidly directing the first and second liquid medications from the first and second pumping means to the needle cannula;

whereby the first and second liquid medications are pumped from the first and second containers by the first and second pumping means, through the needle cannula and into the syringe.

2. A medication dispenser, for use with a first container containing a first, liquid pharmaceutical, a second container containing a second pharmaceutical and a syringe of the type including a needle cannula, a barrel and a plunger, the dispenser comprising:

a body to which the containers and the syringe are mountable;

dual port means for providing first and second gas and liquid ports into the interiors of the first and second containers;

a first passageway fluidly connecting the first and second liquid ports to permit fluid flow from the first container to the second container but not flow in the reverse direction;

first means for pumping the first liquid pharmaceutical into the second container through the first and second liquid ports along the first passageway so the pumped first pharmaceutical mixes with the second pharmaceutical in the second container to create a first mixed liquid pharmaceutical while gasses pass into the first container and out of the second container through the first and second gas ports, respectively;

second means for pumping the first mixed liquid pharmaceutical from the second container through the second liquid port while replacing the first mixed pharmaceutical with gas which passes into the second container through the second gas port; and

means for fluidly directing the first mixed pharmaceutical from the second liquid port to the needle cannula;

whereby the mixed pharmaceutical is pumped from the second container by the second pumping means, through the needle cannula and into the syringe.

3. The dispenser of claim 2 wherein the body includes cavities for housing the container and the syringe.

4. The dispenser of claim 2 wherein the dual port means includes a septum-pierceable, hollow liquid spike and a piston-pierceable, hollow gas spike.

5. The dispenser of claim 2 further comprising means for visually indicating the amount of the mixed pharmaceutical pumped into the syringe.

6. The dispenser of claim 5 wherein the first and second pumping means include means for preventing the pumping of liquid from the second container into the first container.

7. The dispenser of claim 2 wherein the fluidly directly means includes a septum mounted to the body and pierceable by the needle cannula.

8. The dispenser of claim 2 further comprising a gas filter coupled to the gas port.

9. The dispenser of claim 8 wherein the gas filter is coupled to the ambient atmosphere.

10. The dispenser of claim 2 wherein the first pumping means includes a piston and cylinder assembly.

11. The dispenser of claim 10 wherein the first pumping means is actuated by reciprocal movement of the first container.

12. The dispenser of claim 11 wherein the piston and cylinder assembly includes a cylinder and a piston, coupled to the first container, for reciprocal movement with the first container within the cylinder between a delivery position and a replenish position, the cylinder having a cylinder wall.

13. The dispenser of claim 12 wherein the first pumping means includes a check valve fluidly coupling the container and the cylinder.

14. The dispenser of claim 13 wherein:

the check valve includes a flapper element which frictionally engages the cylinder wall as the piston moves between the distal position and the proximal position;

the friction between the cylinder wall and the flapper element being sufficient and the flapper element constructed to cause the flapper element to seal the cylinder from the container and to fluidly couple the cylinder to the container when the piston moves towards the delivery position and towards the replenish position, respectively.

15. The dispenser of claim 2 wherein the fluidly directing means includes supplemental check valves which permit fluid flow from the second liquid port to the needle cannula but prevents fluid flow from the needle cannula to the second liquid port.

16. The dispenser of claim 2 wherein the fluidly directing means includes a resilient pathway element having a flow surface which can deflect according to a fluid pressure applied thereto.

17. The dispenser of claim 16 wherein the resilient pathway element includes an elastomeric material supported on a support surface containing a groove, the elastomeric material being deflectable into the groove thereby deflecting the flow surface.

18. The dispenser of claim 2 wherein the fluidly directing means includes accumulator means for providing a pressurized liquid accumulation region to accommodate any flow restriction created by the needle cannula.

19. A medication dispenser, for use with a first container containing a first, liquid pharmaceutical, a second container containing a second pharmaceutical, a third container containing a third, liquid pharmaceutical and a syringe of the type including a needle cannula, a barrel and a plunger, the dispenser comprising:

a body to which the containers and the syringe are mountable;

dual port means for providing first, second and third gas and liquid ports into the interiors of the first, second and third containers;

a first passageway fluidly connecting the first and second liquid ports to permit fluid flow from the first container to the second container but not flow in the reverse direction;

first means for pumping the first liquid pharmaceutical into the second container through the first and second liquid ports along the first passageway so the pumped first pharmaceutical mixes with the second pharmaceutical in the second container to create a first mixed liquid pharmaceutical while gasses pass into the first container and out of the second container through the first and second gas ports, respectively;

second means for pumping the first mixed liquid pharmaceutical from the second container through the second liquid port and the third, liquid pharmaceutical from the third container through the third liquid port while replacing the first mixed and third pharmaceuticals with gasses which pass into the second and third containers through the second and third gas ports; and

means for fluidly directing the first mixed and third pharmaceuticals from the second and third liquid ports to the needle cannula;

whereby the mixed and third pharmaceuticals are pumped from the second and third containers by the second and third pumping means, through the needle cannula and into the syringe.

20. The dispenser of claim 19 further comprising means for visually indicating the amount of the mixed and third pharmaceuticals pumped into the syringe.

21. The dispenser of claim 19 wherein the first and second pumping means include means for preventing the pumping of liquid from the second container into the first or third containers and for preventing the pumping of liquid from the third container into the first or second containers.

22. The dispenser of claim 19 wherein the fluidly directing means includes supplemental check valves which permit fluid flow from the second and third liquid ports to the needle cannula but prevents fluid flow from the needle cannula to the second and third liquid ports.