Implantable electrical vagal stimulation for prevention or interruption of life threatening arrhythmias

• US 5,330,507 A
• Filed: 04/24/1992
• Issued: 07/19/1994
• Est. Priority Date: 04/24/1992
• Status: Expired due to Term

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Schwartz, Peter J.
• Primary Examiner(s): Kamm, William E.
• Assistant Examiner(s): MANUEL, GEORGE C
• Application Number:
  US07/873,437
• Time in Patent Office: 816 Days
• Field of Search: 128/419 PG, 128/419 P, 128/419 D, 128/705, 128/703, 128/702, 128/697, 128/708, 607/9, 607/14, 607/15
• US Class Current: 607/14
• CPC Class Codes: A61N 1/36114 Cardiac control, e.g. by vagal stimulation stimulating the heart A61N1/362
• CPC Class Codes: A61N 1/3621 for treating or preventing abnormally high heart rate
• CPC Class Codes: A61N 1/36585 controlled by two or more physical parameters

Abstract

A method and apparatus for stimulating the right or left vagus nerve with continuous and/or phasic electrical pulses, the latter in a specific relationship with the R-wave of the patient'"'"'s electrogram. The automatic detection of the need for vagal stimulation is responsive to increases in the heart rate greater than a predetermined threshold, the occurrence of frequent or complex ventricular arrhythmias, and/or a change in the ST segment elevation greater than a predetermined or programmed threshold. The system is described with a microprocessor driven, brady therapy device with programming and telemetry capabilities for recording in memory the aforementioned stimulation triggering indicia, including electrogram segments for periods of time preceding and following each instance of vagal stimulation for telemetry out on command.

Claims

1. A method for treating a cardiac arrhythmia comprising the steps of:

continuously measuring the electrogram of the patient'"'"'s heart;

detecting certain characteristics of said electrogram indicative of tachycardia;

initiating the storage of a sequence of said characteristics of said electrogram upon detection of a tachycardia;

delivering one or more electrical stimulation therapies to the patient'"'"'s nervous system for depressing the patient'"'"'s heart rate;

providing a patient selection trigger to permit a patient to cause the delivery of a preset electrical stimulation therapy to the patient'"'"'s nervous system;

providing patient initiated storage means to permit the patient to initiate storage of said sequence of said characteristics of said electrogram and said delivering of said one or more electrical stimulation therapies to the patient'"'"'s nervous system for depressing the patient'"'"'s heart rate; and

initiating the storage of a further sequence of said characteristics of said electrogram following delivery of said stimulation therapies.

2. The method of claim 1 further comprising the steps of:

examining the QRST segment of the patient'"'"'s electrogram;

measuring the ST segment elevation of said QRST components of said electrogram;

comparing the measured ST segment elevations to a threshold ST segment elevation and counting the number of elevated ST segments exceeding the threshold ST segment elevation; and

delivering said stimulation therapies if a pre-selected number of elevated ST segments among a total number of measured ST segments are found.

3. The method of claims 1 or 2 further comprising the steps of:

detecting successive R-waves of the patient'"'"'s electrogram;

measuring successive R--R intervals of the patient'"'"'s electrogram and comparing the measured R--R intervals against a tachycardia interval threshold; and

delivering said stimulation therapies if a predetermined number of R--R intervals within a run of successive R-waves are less than said tachycardia threshold interval.

4. The method of claim 1 wherein said step of storing the electrogram after delivery of stimulation further comprises the steps of:

confirming that the delivered stimulation therapy successively converted the tachycardia to a heart rate below the tachycardia threshold; and

storing a predetermined number of successive R--R intervals following delivery of a successful therapy.

5. Apparatus for treating a cardiac arrhythmia comprising:

means for continuously measuring the electrogram of the patient'"'"'s heart;

means for detecting certain characteristics of said electrogram indicative of tachycardia;

means for a sequence of said characteristics of said electrogram upon detection of tachycardia;

means for delivering one or more electrical stimulation therapies to the patient'"'"'s nervous system for depressing the patient'"'"'s heart rate;

patient selection trigger means for permitting a patient to cause the delivery of a preset electrical stimulation therapy to the patient'"'"'s nervous system;

patient initiated storage means for permitting the patient to initiate storage of said sequence of said characteristics of said electrogram and said delivering of said one or more electrical stimulation therapies to the patient'"'"'s nervous system for depressing the patient'"'"'s heart rate; and

means for storing of a further sequence of said characteristics of said electrogram following delivery of said stimulation therapies.

6. The apparatus of claim 5 further comprising:

means for examining the QRST segment of the patient'"'"'s electrogram;

means for measuring the ST segment elevation of said QRST components of said electrogram;

means for comparing the measured ST segment elevations to a threshold ST segment elevation and means for counting the number of elevated ST segments exceeding the threshold ST segment elevation; and

means for delivering said stimulation therapies if a preselected number of elevated ST segments among a total number of measured ST segments are found.

7. The apparatus of claims 5 or 6 further comprising:

means for detecting successive R-waves of the patient'"'"'s electrogram;

means for measuring successive R--R intervals of the patient'"'"'s electrogram and comparing the measured R--R intervals against a tachycardia interval threshold; and

means for delivering said stimulation therapies if a predetermined number of R--R intervals within a run of successive R-waves are less than said tachycardia threshold interval.

8. The apparatus of claim 5 wherein said step of storing the electrogram after delivery of stimulation further comprises:

means for confirming that the delivered stimulation therapy successively converted the tachycardia to a heart rate below the tachycardia threshold; and

means for storing a predetermined number of successive R--R intervals following delivery of a successful therapy.

9. A method for treating a cardiac arrhythmia comprising the steps of:

continuously measuring the electrogram of the patient'"'"'s heart;

examining the QRST segment of the patient'"'"'s electrogram;

measuring the ST segment elevation of said QRST components of said electrogram;

comparing the measured ST segment elevation to a threshold ST segment elevation and counting the number of elevated ST segments exceeding the threshold ST segment elevation; and

delivering one or more electrical stimulation therapies to the patient'"'"'s nervous system for depressing the patient'"'"'s heart rate;

providing a patient selection trigger to permit a patient to cause the delivery of a preset electrical stimulation therapy to the patient'"'"'s nervous system; and

providing patient initiated storage means to permit the patient to initiate storage of said sequence of said characteristics of said electrogram and said delivering of said one or more electrical stimulation therapies to the patient'"'"'s nervous system for depressing the patient'"'"'s heart rate.

10. The method of claim 9 further comprising the steps of:

detecting successive R-waves of the patient'"'"'s electrogram;

measuring successive R--R intervals of the patient'"'"'s electrogram and comparing the measured R--R intervals against a tachycardia interval threshold; and

delivering said stimulation therapies if a predetermined number of R--R intervals within a run of successive R-waves are less than said tachycardia threshold interval.