Dual chamber pacemaker with automatically optimized AV delay

• US 5,330,511 A
• Filed: 01/19/1993
• Issued: 07/19/1994
• Est. Priority Date: 01/19/1993
• Status: Expired due to Term

• Current Assignee: Vitatron Medical BV
• Original Assignee: Vitatron Medical BV
• Inventors: Boute, Willem
• Primary Examiner(s): Kamm, William E.
• Assistant Examiner(s): SCHAETZLE, KENNEDY
• Application Number:
  US08/005,744
• Time in Patent Office: 546 Days
• Field of Search: 607/17, 607/19, 607/25, 607/27, 607/9
• US Class Current: 607/25
• CPC Class Codes: A61N 1/368 comprising more than one electrode co-operating with different heart regions A61N1/3622, A61N1/3627 take precedence
• CPC Class Codes: A61N 1/3682 with a variable atrioventricular delay

Abstract

The dual chamber system and method of operation contains an automatic test for determining an optimum AV interval at a test frequency such as LRL. In a preferred embodiment the test is carried out at nighttime, wherein the implanted pacer is set to asynchronous operation at LRL, and AV interval is sequenced through a range from a predetermined AV_min to a predetermined AV_max. The QT interval corresponding to each respective AV interval is determined and stored; the QT data is analyzed to determine the maximum QT interval; and the optimum AV is determined at that which corresponds to the maximum QT. The optimum AV interval thus found is incorporated into the pacer memory for use in timing out AV interval. The optimum AV data may be utilized for determining AV=f_s (rate) for calculating AV interval following each AS, as well as AV=f_p (rate) for calculating AV interval following an atrial pace. Alternately, a test can be performed to determine whether an incremental adjustment of AV delay is indicated. In accordance with the invention, a DDDR pacer with automatic AV delay control can be achieved, without need for an extra sensor.

Claims

1. A dual chamber pacing system having AS means for sensing atrial beats (AS), AP means for generating and delivering atrial pace pulses (AP), VS means for sensing ventricular beats (VS), VP means for generating and delivering ventricular pace pulses (VP), and AV means for timing an AV interval following an atrial event (AS or AP) and for controlling delivery of a VP at an interval according to the function AV=f(rate) following a said atrial event and in the absence of a VS, comprising

determining means for automatically determining an optimized AV interval corresponding to at least one predetermined pacing rate, and

adjusting means for adjusting said function AV=f(rate) to comprise said determined optimized AV interval at said predetermined pacing rate.

2. The dual chamber pacing system as described in claim 1, comprising rate responsive means for controlling pacing rate and wherein said AP and VP means generate pace pulses at a rate between a lower rate limit (LRL) and a upper rate limit (URL), and said predetermined pacing rate is said LRL.

3. The dual chamber pacing system as described in claim 2, wherein said AV means controls AV to vary as a function of rate in a predetermined relationship relative to the determined AV interval at LRL.

4. The pacing system as described in claim 1, wherein said determining means comprises means for delivering atrial and ventricular pace pulses at a fixed rate and varying means for varying the AV interval, and means for measuring the variation of at least one selected hemodynamic variable as a function of said varied AV interval.

5. The pacing system as described in claim 4, wherein said hemodynamic variable is QT interval.

6. The dual chamber pacing system as described in claim 1, wherein said AV means controls said AV to decrease as a function of increasing rate.

7. The dual chamber pacing system as described in claim 1, wherein said determining means comprises programmable test means for carrying out a test for determining optimum AV interval.

8. The dual chamber pacing system as described in claim 7, wherein said test means is programmed to carry out said test at nighttime.

9. The dual chamber pacing system as described in claim 7, wherein said test means comprises changing the value of AV by predetermined increments, while pacing both the patient'"'"'s atrium and ventricle at LRL, and means for measuring and storing values of QT interval corresponding to each respective value of AV.

10. The system as described in claim 1, wherein said adjusting means adjusts AV as a different function of rate following AS and AP respectively.

11. The dual chamber pacing system as described in claim 5, wherein said determining means comprises means for selecting substantially the highest measured value of QT and determining the AV value that corresponds to said highest QT value as said optimum AV interval.

12. The dual chamber pacing system as described in claim 5, wherein said determining means comprises means for processing said QT measurements to determine the approximate maximum value of QT, and determining the AV value that corresponds to said approximate maximum QT value as said optimum AV interval.

13. A method of dual chamber operation by a pacing system implanted in a patient, said pacing system having atrial sense means for sensing natural atrial events (AS) and atrial pace means for delivering atrial pace pulses (AP), ventricular pace means for delivering ventricular pace pulses (VP), synchronizing means for controlling delivery of a said VP at an AV interval following either an AS or AP according to a function AV=f(rate), said method of operation further comprising determining an optimum AV interval at at least one rate, and adjusting said function in accordance with said optimum AV interval, said determining step comprising:

switching said implanted pacing system into a mode wherein AP and VP pulses are delivered to the patient at a predetermined rate, each VP following a prior AP by an AV interval,

testing the AV interval by adjusting the AV interval to a plurality of adjusted intervals, and determining a measure of the patient QT interval corresponding to each respective adjusted AV interval, and

determining from said measures of QT intervals whether the AV interval at said predetermined rate should be changed, and changing the value of the AV interval corresponding to said predetermined rate in accordance with said testing.

14. The method as described in claim 13, comprising carrying out said test at nighttime.

15. A dual chamber pacemaker having means for sensing atrial heartbeats (AS) and for generating ventricular pace pulses (VP) each synchronized to a preceding AS, comprising means for determining the QT intervals following a series of delivered VPs, means for analyzing said QT intervals, and AV means for setting the AV interval between an AS and a following VP, said AV means having adjusting means for adjusting said AV interval as a function of said analyzed QT intervals.

16. A rate responsive dual chamber pacemaker having means for sensing atrial heartbeats (AS), means for generating atrial pace pulses (AP) at a rate variable through a rate range, means for generating ventricular pace pulses (VP) at a rate variable through said rate range, means for synchronizing a VP to a preceding AS, AV means for setting the AV interval between an AS or AP and a following VP, and variable means for sensing the value of a predetermined variable representative of patient cardiac hemodynamics, characterized by

determining means for determining the variation of said predetermined variable with variation of AV interval, and

said AV means having adjusting means for adjusting said AV interval in accordance with said determined variation.

17. The dual chamber pacemaker as described in claim 16, wherein said predetermined variable is QT interval.

18. The dual chamber pacemaker as described in claim 17, wherein said determining means comprises AV change means for changing said AV interval over a predetermined AV interval range while pacing both the atrium and the ventricle at a fixed rate.

19. The dual chamber pacemaker as described in claim 18, comprising means for limiting said adjusting means to adjusting AV interval by only a predetermined amount per adjustment.

20. The dual chamber pacemaker as described in claim 16, further characterized by initiating means for initiating said determining in accordance with predetermined criteria.

21. The dual chamber pacemaker as described in claim 20, wherein said initiating means determines when the patient heart rate is at or below a predetermined LRL.

22. The dual chamber pacemaker as described in claim 16, wherein said determining means comprises means for determining when said predetermined variable has been stable for a predetermined period of time, and means for initiating variation of AV interval only upon determination of said variable stability.

23. The dual chamber pacemaker as described in claim 16, further characterized by said determining means comprising varying means for varying said AV interval to alternate values over a plurality of pacing cycles.

24. A dual chamber pacemaker having means for sensing atrial heartbeats (AS), means for generating atrial pace pulses (AP), means for generating ventricular pace pulses (VP), lead means for delivering said pace pulses and sensing ventricular heartbeats (VS), means for synchronizing a VP to a preceding AS, AV means for setting the AV interval between an AS or AP and a following VP, variable means for sensing the value of a predetermined variable representative of patient cardiac hemodynamics, rate control means for controlling the rate of said ventricular pace pulses as a function of said variable, and characterized by

change means for changing said AV interval in a predetermined manner,

determining means for determining the change in said variable attributable to said AV interval change, and said AV means having adjust means for adjusting the AV interval in accordance with said attributable variable change.

25. The pacemaker as described in claim 24, wherein said rate control means controls said rate over at least a predetermined range, and wherein said change means is operative substantially through said range and said AV means adjusts said AV interval for the rate corresponding to which said variable change is determined.

26. The pacer as described in claim 24, further comprising means for determining said variable from said sensed ventricular heartbeats.