Device for nasal delivery of liquid medications

• US 5,331,954 A
• Filed: 04/27/1993
• Issued: 07/26/1994
• Est. Priority Date: 12/21/1990
• Status: Expired due to Term

• Current Assignee: Novo Nordisk A/S
• Original Assignee: Novo Nordisk A/S
• Inventors: Steengaard, Kim, Rex, Jorn, Elk, Svend
• Primary Examiner(s): Burr, Edgar S.
• Assistant Examiner(s): Asher, Kimberly L.
• Application Number:
  US08/054,913
• Time in Patent Office: 455 Days
• Field of Search: 128/200.14, 128/200.18, 128/200.19, 128/200.22, 128/203.12, 128/203.19, 128/203.21, 128/203.22, 128/203.23, 128/207.18, 604/207-209, 604/211, 604/218, 604/232, 604/135
• US Class Current: 128/200.22
• CPC Class Codes: A61M 11/007 Syringe-type or piston-type sprayers or atomisers
• CPC Class Codes: A61M 15/0065 Inhalators with dosage or measuring devices A61M15/0028 takes precedence; dosage devices incorporated in aerosol cans B65D83/52
• CPC Class Codes: A61M 15/08 Inhaling devices inserted into the nose
• CPC Class Codes: B05B 11/0035 Pen-like sprayers
• CPC Class Codes: B05B 9/0838 supply being effected by follower in container, e.g. membrane or floating piston, or by deformation of container

Abstract

A pen shaped device for nasal administration of doses of a liquid medicine, comprising a first and a second housing element, the first housing element (1) comprising a cartridge for the medicine, this cartridge being at one end closed by a piston (21) and being at its other end closed by a valve (7,9), which may be opened to connect the cartridge to a spray nozzle (12). When the two housing elements are rotated relatively to each other, a nut member (27) is proportional to the rotation moved along a threaded piston rod (22) to compress a helical spring (32) to act via the nut element (27) and the piston rod (22) on the piston (21) to put the content of the cartridge under pressure, which pressure may be released by opening the valve (7,9) to lead the medicine in the cartridge to the nozzle (12).

Claims

1. A device for nasal administration of a number of measured doses of a liquid, medicine, especially insulin, comprising a first and a second housing element and means coupling said housing elements together to allow rotation but no axial displacement of the first housing element (1) with respect to the second housing element (2), said first housing element (1) comprising a cartridge containing liquid medicine and being sealed by a piston (21) at a first end coupled to the second housing element (2) and being at its other end closed by a valve (7,9) to communicate the liquid medicine in the cartridge with a spray nozzle (12) upon opening of said valve characterized in that the device further comprises a threaded piston rod (22) engaging the piston (21) of the cartridge irrotational with respect to the first housing element (1) and disposed in the second housing element (2) to move axially therein, a nut element (27) mounted irrotational but axially displaceably in the second housing element (2) and engaging the thread of the piston rod (22), a helical spring (32) abutting at one end an internal annular abutment on the second housing element (2) and at its other end a shoulder on the nut element (27) to press the nut element and thereby the piston rod (22) and the piston (21) in the direction towards an outlet end of the cartridge to set the liquid medicine therein under pressure, means for spraying out a dose of the liquid medicine under pressure upon opening said valve, the housing elements (1,2), the piston rod (22), and the nut element (27) cooperating so that relative rotation between the housing elements (1,2) in a selected direction causes relative rotation between the rod (22) and the nut element, making the nut element move axially in the second housing element (2) in a direction to compress the helical spring (32).

2. A device according to claim 1, characterized in that the piston rod (22) is snap locked into the piston (21).

3. A device according to claim 1, characterized in that the nozzle (12) sprays out the liquid at an angle of 0°

-30°

.

4. A device according to claim 1, characterized in that the nut element (27) defines at least one radially protruding, axially extending projection (29) on an exterior portion thereof;

and the projection is received in an axially extending groove in an inner portion of the second housing element (2).

5. A device according to claim 1, characterized in that a stop (30,41) is provided limiting axial movement of the nut element (27) into the second housing element (2).

6. A device according to claim 1, characterized in that a stop (40) is provided limiting the movement of the nut element (27) along the piston rod (22).

7. A device according to claim 1, further characterized in a removable protective cap (34) configured to receive the first housing element (1) and having abutting edges that abut corresponding abutting edges on the second housing element (2);

and means (36,37) for releasably coupling the protective cap (34) and the first housing element (1) for rotation together, so that rotation of the protective cap (34) with respect to the second housing element (2) causes rotation of the first housing element (1) with respect to the second housing element (2).

8. A device according to claim 7, characterized in that the abutting edges of the second housing element (2) and the protective cap (34) comprise pointing means and scale means, respectively, for measuring the relative rotation of the protective cap (34) with respect to the second housing element (2).

9. A device according to claim 8, characterized in that means are provided for providing detents at selected rotational positions of the first housing element (1) with respect to the second housing element (2).

10. A device according to claim 9, characterized in that the coupling means (36,37) allow the protective cap (34) to receive the first housing element (1) in multiple different angular positions of the protective cap (34) with respect to the first housing element (1) to allow the protective cap (34) to be oriented at a selected position with respect to the second housing element (2), regardless of the detent rotational position of the first housing element (1) in the second housing element (2).

11. A device according to claim 10, characterized in that the interlocking means comprise a recess (38) on the abutting edges of the protective cap (34) and a projection (39) on the abutting edges of the second housing element (2), the projection (39) being shaped to fit into the recess (38) to define the selected position.

12. A device according to claim 9, characterized in that the abutting edges of the protective cap and the second housing element have interlocking means (38,39) for defining a selected angular position of the protective cap (34) with respect to the second housing element (2).

13. A device according to claim 1, characterized in that the piston rod (22) is made irrotational with respect to the first housing element (1) by fitting through an opening in an anti-rotation disc (23), the opening being mainly circular with at least one projection (26) protruding into the opening, by the piston rod (22) having a corresponding profile with recesses (25) corresponding to the projections (26), and by the anti-rotation disc (23) being at its periphery provided with alternating spaces and teeth (42) fitting into a castellated end of the first housing element (1).

14. A device according to claim 13, characterized in that the anti-rotation disc (23) serves as an abutment for the nut element (27) and limits movement of the nut element towards the cartridge.

15. A device according to claim 14, characterized in that the abutment between the nut element (27) and the anti-rotation disc (23) are formed as annular ramps (31) which when in mutual abutment allow only relative rotation of the first and second housing element in a device loading direction.

16. A device according to claim 15, characterized in that the nut element (27) has an tubular extension coaxially surrounding the piston rod (22) and terminated by a knob (33) at an outer end of the second housing element (2), the knob (33) being flush with the edge of the outer end of the second housing element when the annular ramps of the anti-rotation disc and the nut element are in mutual abutment.