Spectrophotometric blood analysis
First Claim
1. A method for optically determining blood parameters, said method comprising directing a light beam into a patient'"'"'s blood, detecting and measuring the light emerging from the blood, and compensating for any change in light beam geometry induced by any change in blood electrolyte composition.
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Abstract
A method and device are described which are particularly useful for continuous on-line monitoring of hematocrit and other blood parameters. The effect of change in blood electrolyte composition, for example, in blood sodium concentration, is taken into consideration. This effect has been found to change light beam geometry, and is taken advantage of to provide for blood sodium concentration measurement. The devices may be applied to extracorporeal circuits or to body parts capable of being transilluminated. The devices may be used to optimize dialysis, and also for monitoring optically detectable, exogenous macromolecules.
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Citations
21 Claims
- 1. A method for optically determining blood parameters, said method comprising directing a light beam into a patient'"'"'s blood, detecting and measuring the light emerging from the blood, and compensating for any change in light beam geometry induced by any change in blood electrolyte composition.
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14. A method for optically determining the blood concentration of macromolecules useful in evaluating exchange properties of blood vessels of a patient, comprising adding to the blood of the patient, a macromolecular mixture comprising a first macromolecular component characterized by a first vascular transport-affecting property and a first optically detectable property, and a second macromolecular component characterized by a second vascular transport-affecting property and a second optically detectable property, wherein said first and second transport-affecting properties differently affect transvascular transport, and wherein said first optically detectable property is optically distinct from said second optically detectable property;
- and optically detecting change in blood concentration of at least one component of said macromolecular mixture, using a wavelength appropriate for each component determined.
- View Dependent Claims (15, 16)
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17. A method for optically determining blood sodium concentration, said method comprising directing a light beam into a patient'"'"'s blood, detecting and measuring the light emerging from the blood, and evaluating any change in scatter of said light beam by comparison to a sodium reference, whereby an absolute blood sodium concentration may be obtained.
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18. A device for optically determining blood parameters, said device comprising means for generating a light beam suitable for being directed into a patient'"'"'s blood;
- first detecting means and second detecting means each disposed at a suitable location to be sensitive to any change in scatter of said light beam, but differently disposed with respect to said light beam;
sodium concentration reference means; and
signal evaluation means in operative communication with said first detecting means, said second detecting means, and said sodium concentration reference means. - View Dependent Claims (19, 20, 21)
- first detecting means and second detecting means each disposed at a suitable location to be sensitive to any change in scatter of said light beam, but differently disposed with respect to said light beam;
Specification