Equipment for testing or measuring brain activity

• US 5,331,969 A
• Filed: 08/02/1990
• Issued: 07/26/1994
• Est. Priority Date: 07/30/1985
• Status: Expired due to Term

• Current Assignee: Institute For Innovation and Enterprise Ltd.
• Original Assignee: Swinburne Limited
• Inventors: Silberstein, Richard B.
• Primary Examiner(s): Pellegrino, Stephen C.
• Assistant Examiner(s): Tucker, Guy V.
• Application Number:
  US07/561,976
• Time in Patent Office: 1,454 Days
• Field of Search: 128/731, 128/732, 128/745, 364/413.02, 364/413.05
• US Class Current: 600/544
• CPC Class Codes: A61B 2562/0215 Silver or silver chloride containing
• CPC Class Codes: A61B 2562/046 in a matrix array
• CPC Class Codes: A61B 5/1106 to assess neuromuscular blockade, e.g. to estimate depth of anaesthesia
• CPC Class Codes: A61B 5/161 Flicker fusion testing eye testing A61B3/00
• CPC Class Codes: A61B 5/291 for electroencephalography [EEG]
• CPC Class Codes: A61B 5/377 using evoked responses
• CPC Class Codes: A61B 5/378 Visual stimuli
• CPC Class Codes: A61B 5/4076 Diagnosing or monitoring particular conditions of the nervous system A61B5/4821, A61B5/4824 take precedence
• CPC Class Codes: A61B 5/6803 Head-worn items, e.g. helmets, masks, headphones or goggles
• CPC Class Codes: A61B 5/7207 of noise induced by motion artifacts

Abstract

Electrical activity of the brain is analysed by the application of a repetitive stimulus so as to evoke a steady state response, changes or differences in the steady state response being used as a measure of said electrical activity. The spatial distribution of the activity can be displayed as a topographical representation of the brain, which representation can be updated so as to provide a substantially real-time display. A neuro-psychiatric workstation incorporating such a display can be used for instance for various research purposes.

Claims

1. Apparatus for assessing electrical activity of a brain of a subject comprising:

first stimulus means for generating and applying a repetitive stimulus to the brain;

second stimulus means for generating and applying to the brain a time varying stimulus relating to a cognitive task; and

detection means for distinguishing and detecting a steady state response of the brain to said first stimulus, and for detecting a change or changes in said response during a data acquisition period when the repetitive stimulus and a time varying cognitive task stimulus are simultaneously applied to the brain of the subject, wherein the detection means can detect time variations in brain activity of the subject which occur during the data acquisition period.

2. Apparatus according to claim 1, further comprising:

assessment means for assessing the electrical activity of the brain in terms of said change or changes.

3. Apparatus according to claim 1 wherein said first stimulus means comprises a light source and control means for varying the intensity of the light source in a repetitive manner.

4. Apparatus according to claim 3 wherein said light source comprises an array of light emitting diodes.

5. Apparatus according to claim 3 wherein said detection means comprises at least one electrode for application to the head of said subject to detect electrical activity of the brain, and said stimulus means further comprises optical waveguide means for directing light from said light source to an eye or field of view of the subject, said light source being remote from said electrode, in use.

6. Apparatus according to claim 1 wherein said detection means comprises an array of electrodes for application to the head of said subject to detect electrical activity of the subject'"'"'s brain, signal processing and data acquisition equipment for processing the outputs of the electrodes, said signal processing and data acquisition equipment comprising a pre-processing portion which, in use, samples said outputs at a rate which is an integral multiple of the frequency of the repetitive stimulus, and an analog to digital converter, the output of said converter being suitable for supply to a computational or storage portion.

7. Apparatus according to claim 6 wherein said signal processing and data acquisition equipment further comprises a computational portion for performing preliminary analysis of said steady state response.

8. Apparatus according to claim 7, further comprising assessment means for assessing the electrical activity of the brain in terms of the change or changes in the response, wherein said assessment means comprises computational means and display control means, said assessment means, in use, carrying out analysis of the steady state response in terms of a spatial distribution with respect to said brain and said display control means, in use, controlling display apparatus to show said spatial distribution.

9. Apparatus according to claim 8 wherein said analysis by the assessment means comprises the assessment of changes in said steady state response and said spatial distribution comprises the distribution with respect to said brain of said changes in the steady state response.

10. Apparatus according to claim 6 wherein said first stimulus means and said pre-processing portion are synchronized.

11. Apparatus according to claim 10 wherein said first stimulus means comprises a frequency generator which controls the sampling rate of said pre-processing portion.

12. Apparatus according to claim 1 wherein said first stimulus means comprises a ramp generator to control the amplitude of the stimulus at start-up such that it increases from zero to a predetermined amplitude at a predetermined rate.

13. Apparatus according to claim 1 further comprising epileptic activity detecting means, comprising means for detecting a significantly large response to said first stimulus, and automatic termination means for terminating said first stimulus on detection of said significantly large response.

14. A method of assessing brain activity of a subject comprising the steps of obtaining a steady state evoked potential of a subject, causing the subject to perform a time varying cognitive task and assessing time variations in the brain activity of the subject on the basis of changes in said potential which occur while said time varying task is being performed by the subject.

15. A method as claimed in claim 14, wherein said potential is obtained by applying a periodically repetitive stimulus to the brain.

16. A method as claimed in claim 15, wherein said periodically repetitive stimulus comprises a signal which sinusoidally varies in intensity.

17. A method as claimed in claim 16, wherein said signal is visual and said potential is a steady state visually evoked potential (SSVEP).

18. A method as claimed in claim 17, including the step of displaying the changes in said SSVEP on a visual display.

19. A method as claimed in claim 18, wherein data acquisition for said assessing step is carried out at a rate which enables high resolution in the time domain of said changes in SSVEP.

20. A method as claimed in claim 18 or 19, including the step of applying an array of electrodes to the head of said subject, obtaining a spatial distribution of said SSVEPs and displaying the changes in respective SSVEPs according to the spatial distribution.

21. A method as claimed in claim 17, wherein the magnitude M_n and phase of the SSVEP is determined by the formula:

##EQU6## where a_n and b_n are the moving average of the single cycle Fourier coefficients of the repetitive stimulus,

M_n is the magnitude of the sinusoidal SSVEP, and

θ

_n is the phase difference between the sinusoidal stimulus and the sinusoidal SSVEP.

22. Apparatus for assessing brain activity of a subject comprising first means for obtaining a steady state evoked potential of a subject, second means for causing the subject to perform a time varying cognitive task and third means for assessing time variations in the brain activity of the subject on the basis of changes in said potential which occur while said time varying task is being performed by the subject.

23. Apparatus as claimed in claim 22, wherein said first means includes stimulus means for applying a periodically repetitive stimulus to the brain.

24. Apparatus as claimed in claim 23, wherein said stimulus means generates a signal which sinusoidally varies in intensity.

25. Apparatus as claimed in claim 24, wherein said signal is visual and said potential is a steady state visually evoked potential (SSVEP).

26. Apparatus as claimed in claim 25, further including display means for displaying the changes in said SSVEP.

27. Apparatus as claimed in claim 26, wherein said first, second and third means and display means operate at a rate which enables said display means to display changes in said SSVEP with high resolution in the time domain.

28. Apparatus as claimed in claim 26 or 27, wherein said first means includes an array of electrodes for application to the head of said subject and wherein said third means includes computational means and display control means wherein the third means determines changes in SSVEP in terms of spatial distribution and the display control means controls the display means to show spatial distribution.

29. A method of assessing activity of a brain of a subject comprising the steps of:

applying a periodic control signal having a preselected frequency to the brain of the subject;

obtaining an electroencephalographic (EEG) signal from the subject while said control signal is being applied; and

analyzing the EEG signal to determine the magnitude or phase of that component of the EEG signal which corresponds in frequency to said control signal;

wherein said method further comprises the steps of applying said control signal and a cognitive task stimulus simultaneously to the subject during a data acquisition period;

obtaining and analyzing the EEG signal to determine the magnitude or phase of said component during said data acquisition period;

determining the change in the magnitude or phase of said component of the EEG signal during said data acquisition period; and

assessing time variations in brain activity of the subject in accordance with said change.

30. A method as claimed in claim 29, wherein the control signal comprises a sinusoidal signal.

31. A method as claimed in claim 30, wherein the control signal is a visual signal which is varied in intensity.

32. A method as claimed in claim 31, wherein a semi-reflective screen is placed between the subject and a source of said visual signal and the visual control signal is reflected toward the eye or eyes of the subject.

33. A method as claimed in claim 32, wherein information relating to said cognitive task is displayed to the subject on a television screen.

34. Apparatus for assessing the activity of a brain of a subject comprising:

means for applying a periodic control signal having a predetermined frequency to the brain of the subject;

applying means for applying a cognitive task stimulus to the brain of the subject;

means for deriving the EEG signal from the subject during a data acquisition period in which the control signal and the cognitive task stimulus are simultaneously applied to the brain of the subject; and

analyzing means for determining the change in magnitude or phase of that component of the EEG signal which is attributable to the periodic control signal from one state in which the brain of the subject has applied thereto only the control signal and another state when the brain of the subject has applied thereto both the control signal and the cognitive task stimulus, whereby the analyzing means can assess time variations of brain activity which occur during the data acquisition period.

35. Apparatus as claimed in claim 34, wherein the means for applying the control signal comprises a source or red radiation and means for sinusoidally varying the intensity of the radiation at the predetermined frequency.

36. Apparatus as claimed in claim 35, wherein said frequency is in the range 1 to 100 Hz.

37. Apparatus as claimed in claim 36, wherein said frequency is approximately 10 Hz.

38. Apparatus as claimed in claim 34, wherein said means for applying the control signal comprises as array of LEDs.

39. Apparatus as claimed in claim 38, wherein the LED arrays are mounted upon spectacle frames.

40. Apparatus as claimed in claim 39, wherein said applying means for applying a cognitive task stimulus comprises a television screen and wherein the spectacle frames include semi-reflective screens which permit the subject to view the television screen directly, the screens reflecting radiation from the LED arrays towards the eye or eyes of the subject.

41. Apparatus as claimed in claim 35, wherein the analyzing means includes discriminating means having a sample and hold circuit which holds the output value of said EEG signal at the end of each period of the frequency component of the stimulus.

42. Apparatus as claimed in claim 41, wherein the discriminating means includes an arithmetic unit for calculating the magnitude M_n of the EEG signal at said frequency by taking the square root of the sum of the squares of said output values.

43. Apparatus as claimed in claim 34, wherein said periodic control signal is a visual stimulus and wherein said means for applying a periodic control signal includes support means for supporting at least one semi-reflective screen adjacent to at least one of the eyes of the subject whereby the subject can view directly the visual stimulus, and a source of visible radiation carried by the support means for reflecting radiation from said source towards the eye or eyes of the subject so as to provide said control signal.

44. Apparatus as claimed in claim 34, wherein the analyzing means comprises means for calculating a normalized mean response from the responses of each of a plurality of subjects to the control signal alone, and for determining during the data acquisition period said change in magnitude for each subject by subtracting the normalized mean response from the magnitude of said component of the EEG signal determined for each subject for simultaneously display of the control signal and the cognitive task stimulus.

45. A method of assessing brain activity of a subject comprising the steps of obtaining a steady state evoked potential of a subject, causing the subject to perform a cognitive task and assessing time variations in the brain activity of the subject on the basis of changes in said potential which occur while said task is being performed by the subject.