Heterocyclically substituted piperazinoakylbenzoxazine and piperazinoalkylbenzothiazine compounds, processes for preparing them, and medicaments containing them
First Claim
1. A compound corresponding to the formula I ##STR28## wherein X denotes oxygen or sulfur,Y denotes oxygen or sulfur,R1 denotes hydrogen or lower alkyl,R2 denotes hydrogen, lower alkyl, halogen, lower alkoxy, hydroxy, nitro or trifluoromethyl, andR3 denotes hydrogen, lower alkyl, halogen or lower alkoxy, orR2 and R3 are bonded to adjacent carbon atoms and together denote an alkylenedioxy group having 1-2 carbon atoms,n is an integer from 0 to 4, andR4 is a 6-membered unsaturated heterocycle containing 1 or 2 nitrogen atoms not directly bonded to the piperazine ring, said heterocycle being substituted by 0 to 2 substituents bonded to carbon atoms selected from the group consisting of lower alkyl, lower alkoxy and halogen,and physiologically acceptable acid addition salts thereof.
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Abstract
Pharmacologically active compounds corresponding to the general formula I ##STR1## which are optionally substituted in the benzene ring and in which X denotes oxygen or sulfur,
Y denotes oxygen or sulfur,
R1 denotes hydrogen or lower alkyl,
n is an integer from 0 to 4, and
R4 is an optionally substituted 6-membered unsaturated heterocycle containing 1 or 2 nitrogen atoms not directly bonded to the piperazine ring,
and physiologically acceptable acid addition salts thereof.
11 Citations
11 Claims
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1. A compound corresponding to the formula I ##STR28## wherein X denotes oxygen or sulfur,
Y denotes oxygen or sulfur, R1 denotes hydrogen or lower alkyl, R2 denotes hydrogen, lower alkyl, halogen, lower alkoxy, hydroxy, nitro or trifluoromethyl, and R3 denotes hydrogen, lower alkyl, halogen or lower alkoxy, or R2 and R3 are bonded to adjacent carbon atoms and together denote an alkylenedioxy group having 1-2 carbon atoms, n is an integer from 0 to 4, and R4 is a 6-membered unsaturated heterocycle containing 1 or 2 nitrogen atoms not directly bonded to the piperazine ring, said heterocycle being substituted by 0 to 2 substituents bonded to carbon atoms selected from the group consisting of lower alkyl, lower alkoxy and halogen, and physiologically acceptable acid addition salts thereof.
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11. A compound corresponding to the formula IV ##STR29## wherein X denotes oxygen or sulfur,
R1 denotes hydrogen or lower alkyl, R2'"'"' denotes hydrogen, lower alkyl, halogen, lower alkoxy, nitro or trifluoromethyl, and R3 denotes hydrogen, lower alkyl, halogen or lower alkoxy, or R2'"'"' and R3 are bonded to adjacent carbon atoms and together denote an alkylenedioxy group having 1-2 carbon atoms, and n is an integer from 0 to 4.
Specification
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- Resources
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Current AssigneeSolvay Pharmaceuticals GmbH (Abbvie Incorporated)
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Original AssigneeKali-Chemie Pharma GmbH
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InventorsFloc'h, Francois, White, Richard, Jasserand, Daniel
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Primary Examiner(s)Shah, Mukund J.
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Assistant Examiner(s)Grumbling, Matthew V.
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Application NumberUS07/977,859Time in Patent Office616 DaysField of Search544/32, 544/52, 544/101, 544/105, 514/224.2, 514/224.5, 514/229.8, 514/230.5US Class Current514/224.2CPC Class CodesC07D 265/36 condensed with one six-memb...C07D 279/16 condensed with one six-memb...
