Human collagen processing and autoimplant use
First Claim
1. Autoimplantable, cross-linkable, telopeptide-containing, naturally crosslinked human collagen composition comprising a chemically modified collagenous substance produced by reacting comminuted intact human tissue containing native telopeptide-containing collagen with an amine reactive acylating agent, a carboxylic acid reactive esterifying agent or a combination thereof to at least partially solubilize said native telopeptide-containing collagen, wherein said comminuted intact human tissue has been treated to remove non-collagenous proteins.
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Accused Products
Abstract
Production of a chemically modified, crosslinkable, telopeptide-containing, naturally crosslinked, solubilized collagen from tissue obtained from a sole human donor, for implanting in the same donor, by chemically modifying the tissue, e.g. by acylation and/or esterification, to form an autoimplantable, crosslinkable, telopeptide-containing, naturally crosslinked, collagen product, as a completely solubilized collagen solution, optionally of high index of refraction for correcting sight or as a partially solubilized collagen suspension; and use of the product for altering the condition of in situ tissue of the same human donor by autoimplantation, such as by crosslinking the product to form an implant device, by placing an effective amount of the product at the tissue site and crosslinking the product in situ, or by partially crosslinking the product and placing an effective amount thereof at the tissue site and optionally further crosslinking the product in situ.
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Citations
21 Claims
- 1. Autoimplantable, cross-linkable, telopeptide-containing, naturally crosslinked human collagen composition comprising a chemically modified collagenous substance produced by reacting comminuted intact human tissue containing native telopeptide-containing collagen with an amine reactive acylating agent, a carboxylic acid reactive esterifying agent or a combination thereof to at least partially solubilize said native telopeptide-containing collagen, wherein said comminuted intact human tissue has been treated to remove non-collagenous proteins.
- 10. Autoimplantable, cross-linkable, telopeptide-containing, naturally crosslinked human collagen composition comprising a chemically modified collagenous substance produced by chemically modifying comminuted intact human tissue containing native telopeptide-containing collagen with an amine reactive acylating agent, a carboxylic acid reactive esterifying agent or a combination thereof to solubilize said native telopeptide-containing collagen wherein said comminuted intact human tissue has been treated to remove non-collagenous proteins.
- 19. A composition for autoimplantation into a human comprising autoimplantable, cross-linkable, telopeptide-containing, naturally crosslinked human collagen derived from comminuted intact human tissue, said collagen having at least one selected from the group consisting of aliphatic amido group, aromatic amido group, aliphatic sulfonamido group, aromatic sulfonamido group, aliphatic ester group and aromatic ester group.
Specification