Apparatus and visual display method for training in the power use of aerosol pharmaceutical inhalers

• US 5,333,106 A
• Filed: 10/09/1992
• Issued: 07/26/1994
• Est. Priority Date: 10/09/1992
• Status: Expired due to Term

• Current Assignee: Airways Medical Technologies Incorporated, Aradigm Corporation
• Original Assignee: Circadian, Inc.
• Inventors: Lanpher, Ted W., Lanpher, Gregory B., Minar, Steven H., Mishelevich, David J.
• Primary Examiner(s): Envall, Jr., Roy N.
• Assistant Examiner(s): Tran, Khai
• Application Number:
  US07/958,868
• Time in Patent Office: 655 Days
• Field of Search: 364/413.01, 364/413.02, 364/413.04, 428/200.12, 428/200.23, 428/200.17, 428/725, 428/726, 428/727, 73/23.22
• US Class Current: 600/538
• CPC Class Codes: A61M 15/00 Inhalators drug delivery in endotracheal tubes A61M16/04
• CPC Class Codes: A61M 15/0083 Timers
• CPC Class Codes: G09B 23/30 Anatomical models G09B23/281 - G09B23/288 take precedence
• CPC Class Codes: G09B 5/02 with visual presentation of the material to be studied, e.g. using film strip
• CPC Class Codes: Y10S 128/905 Feedback to patient of biological signal other than brain electric signal

Abstract

An apparatus for interactive training of a patient in the use of an aerosol inhaler includes a feedback display based upon air flow versus volume data in order to train patients to use a proper sequence of inhalation steps to insure maximum delivery of an aerosol pharmaceutical to target sites in the lungs. Flow and volume data are displayed to provide the patient and physician with a real-time, interactive representation of the inhalation process. Visual feedback to the patient includes a portrayal of the lungs which may be either three dimensional or an outline form in addition to or instead of an X-Y display. An important element of visual feedback is the portrayal of the distribution of representative droplets of aerosol medication in various stages of inhalation and breath holding. Thus, the patient is provided with meaningful feedback representative of the actual distribution of aerosol medication. The real-time representation of the delivery of medication to the lungs enables a patient to derive a maximum therapeutic benefit from pharmaceuticals which are administered through inhalation. The improved feedback also enables a patient to learn proper inhalation techniques which enable therapeutic agents to be such as aerosol glucocorticoids to be delivered directly to target sites in the lungs thereby bypassing the digestive system and obviating adverse side effects. The improved visual feedback to the patient representing the actual distribution of inhaled aerosol in the lungs conveys a conceptual understanding of the proper inhalation process and greatly increases the likelihood that a patient will learn and retain the correct inhalation technique.

Claims

1. An interactive inhaler training device for maximizing delivery of an airborne medication to a target site in a patient'"'"'s lungs comprising:

an inhaler means including a source of airborne medication for inhalation by a patient;

a flow measurement means coupled with said inhaler means for measuring the flow of air through said inhaler means;

a microprocessor means coupled with said flow measurement means for producing a measure of flow as a function of inhaled volume;

storage means, coupled with said microprocessor means, for storing said flow and volume values and for storing additional parameters determining medication distribution to said target site;

display means, coupled with said microprocessor means for providing a visual display based on at least flow versus volume feedback to a patient for enabling a patient to maximize delivery of medication to said target site.

2. An apparatus according to claim 1 wherein said microprocessor means further includes means for recording the time of actuation of said inhaler means for calculating the timing of device actuation and means for recording the duration of inhalation and breath holding, and for applying said measured values to said storage means.

3. An apparatus according to claim 1 wherein said inhaler means includes a dry powder generator.

4. An apparatus according to claim 1 wherein said source of airborne medication comprises a pressurized canister of aerosol medication.

5. An apparatus according to claim 2 wherein said display means comprises means for superimposing said measured values of volume and flow simultaneously on an X-Y axis display to provide instantaneous visual feedback of a patient'"'"'s inhalation.

6. An apparatus according to claim 5 wherein said display means comprises means for providing at least a two-dimensional portrayal of a patient'"'"'s respiratory system and showing movement of medication into the patient'"'"'s lungs in response to simultaneous flow and volume measurements of the patient'"'"'s breathing.

7. An improved system for maximizing the delivery of an airborne medication, or the like to target sites in a patient'"'"'s lungs, including airways and alveoli comprising:

inhaler means including a canister of airborne medication for delivery to the patient'"'"'s lungs;

flow measuring means coupled with said inhaler means for measuring the flow of air through said inhaler means;

at least one microprocessor means coupled with said flow measurement means for recording measured values of flow and volume, including means for storing quantifiable parameters relating to patient lung function and for projecting patterns of medication deposition at the receptor sites within the patient'"'"'s bronchial tree based on said parameters of lung function;

visual display means coupled with said microprocessor means for providing at least at two-dimensional graphic portrayal of the movement of said medication to the target sites.

8. An apparatus according to claim 7 wherein said graphic display means includes means for illustrating the deposition of said medication by means of sedimentation and diffusion in the airways and alveoli.

9. An apparatus according to claim 8 wherein said graphic display means includes means for illustrating expulsion of an inhaled substance in and out of the patient'"'"'s lungs during inhalation expiration and breath holding.

10. An inhalation training system for facilitating maximized delivery of an airborne medication to receptor sites in a patient'"'"'s lungs comprising:

inhaler means for providing a quantity of said medication or the like to a patient'"'"'s lungs;

flow measurement means coupled with said inhaler means for measuring a patient'"'"'s breathing through said inhaler;

microprocessor means responsive to said flow measurement means and including means for modulating quantifiable physiologic parameters indicative of a patient'"'"'s lung function to provide a projected target envelope representative of maximized medication distribution in the lungs of a patient based on said physiologic parameters;

display means for displaying said projected target envelope including means for measuring a patient'"'"'s actual breathing performance with said target envelope for providing an improved inhalation response to said patient.

11. a system according to claim 10 wherein said microprocessor means includes:

means for integrating the flow of air over time to produce a measure of the volume of air inhaled;

means for manipulating the values of quantifiable physiologic variables governing medication distribution in the lungs to produce a display of graphic images capable of conveying meaning and discrimination.

12. A system according to claim 11 wherein said quantifiable parameters include predicted lung volume and time flow rate values for a specific patient.

13. An apparatus according to claim 10 wherein said display means includes means for superimposing the measured values of the patient'"'"'s inhalation simultaneously on the target envelope in order to provide visual feedback of the patient'"'"'s breathing.

14. A system according to claim 13 wherein said display means includes means for providing at least two-dimensional graphic portrayal of the human lungs and bronchial tree with the lungs expanding or contracting in response to simultaneous flow and volume measurements of a patient'"'"'s breathing.

15. An apparatus according to claim 13 wherein said display means includes means for providing a target envelope on an X-Y axis and for superimposing actual performance on sad target envelope.

16. A system according to claim 10 wherein display means includes means for generating a first set of graphic images capable of conveying meaning and discrimination with respect to a patient'"'"'s projected inhalation and delivery pattern of medication to receptor sites in the patient'"'"'s lungs;

and

means for generating a second set of graphic images capable of conveying meanings and discrimination, superimposed on said first set, which are representative of the patient'"'"'s measured inhalation performance.

17. A system for training a patient in the use of an aerosol inhaler, or the like comprising:

an inhaler means containing a quantity of medication for application to a target site in a patient'"'"'s lungs;

flow measurement means coupled with said inhaler means for providing an output signal representative of the flow of air into the patient'"'"'s lungs upon inhalation from said inhaler means;

microprocessor means responsive to said output signal, including means for providing a measure of the volume of medication inhaled, said microprocessor means further comprising means for computing a projected delivery pattern of said medication to ad target site within the patient'"'"'s lungs based upon measured parameters of the patient'"'"'s inhalation and breath-hold maneuver;

storage means coupled with said microprocessor means for receiving a plurality of values representative of said measured parameters of the patient'"'"'s inhalation and breath-hold maneuver;

display means coupled with said microprocessor means for providing a visual display of a projected pattern of medication distribution at the target site of the patient'"'"'s lungs based upon said measured parameters of the patient'"'"'s

inhalation and breath-hold maneuver.

18. An apparatus according to claim 17 wherein said display means includes means for displaying an image representative of the diffusion and deposition of medication into a patient'"'"'s airways and the distribution of said medication in and out of the patient'"'"'s lungs during inhalation, expiration and breath holding.

19. An apparatus according to claim 17 wherein display means comprises a numerical score representing a rating of the likely level of success in delivering the desired dose of medication to the receptor sites in the respiratory tract, such as score of one to ten.

20. An apparatus according to claim 17 wherein said microprocessor, storage means coupled with said microprocessor, and display means are provided by a multimedia computer such as a video game apparatus.

21. An inhaler training device for maximizing the delivery of an airborne medication to receptor sites in a patient'"'"'s lungs comprising:

an inhaler means including a source of airborne medication for inhalation by a patient;

a flow measurement means coupled with said inhaler means for measuring the flow of air through said inhaler means;

a microprocessor means coupled with said flow measurement means for integrating the flow of air over time to produce a measure of volume inhaled;

storage means, coupled with said microprocessor means, for storing said measured flow and volume values and for storing additional quantifiable diagnostic parameters relating to projected patterns of medication distribution to receptor sites in a patient'"'"'s lungs;

a three dimensional display means for portrayal of a patient'"'"'s lungs and airways and for showing the projected deposition of medication therein.