Method and apparatus for processing a minute portion of a specimen
First Claim
1. A method for detecting a photoacoustic signal comprising the steps of:
- modulating the intensity of light obtained from a light source at a predetermined modulation frequency;
exciting a specimen by directing said intensity-modulated light onto the specimen, thereby generating a photoacoustic effect in the specimen;
detecting the photoacoustic effect generated in the specimen and producing a detection signal indicative of the detected photoacoustic effect; and
extracting information about the surface and interior of the specimen from said detection signal;
wherein the intensity-modulated light is emitted from an aperture of a near-field optical scanning microscope used in directing said intensity-modulated light onto the specimen while a distance between the aperture of the near-field optical scanning microscope and the surface of the specimen in maintained constant irrespective of the photoacoustic effect generated in the specimen.
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Abstract
A method for detecting a photoacoustic signal includes the steps of modulating the intensity of light obtained from a light source at a predetermined modulation frequency, exciting a specimen by directing the intensity-modulated light onto the specimen, thereby generating a photoacoustic effect in the specimen, detecting the photoacoustic effect generated in the specimen and producing a detection signal indicative of the detected photoacoustic effect, and extracting information about the surface and interior of the specimen from the detection signal, wherein the intensity-modulated light is emitted from an aperture of a near-field optical scanning microscope used in directing the intensity-modulated light onto the specimen while a distance between the aperture of the near-field optical scanning microscope and the surface of the specimen is maintained constant irrespective of the photoacoustic effect generated in the specimen.
71 Citations
8 Claims
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1. A method for detecting a photoacoustic signal comprising the steps of:
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modulating the intensity of light obtained from a light source at a predetermined modulation frequency; exciting a specimen by directing said intensity-modulated light onto the specimen, thereby generating a photoacoustic effect in the specimen; detecting the photoacoustic effect generated in the specimen and producing a detection signal indicative of the detected photoacoustic effect; and extracting information about the surface and interior of the specimen from said detection signal; wherein the intensity-modulated light is emitted from an aperture of a near-field optical scanning microscope used in directing said intensity-modulated light onto the specimen while a distance between the aperture of the near-field optical scanning microscope and the surface of the specimen in maintained constant irrespective of the photoacoustic effect generated in the specimen. - View Dependent Claims (2, 3, 4)
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5. An apparatus for detecting a photoacoustic signal comprising:
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a light source; modulation means for modulating the intensity of light from said light source at a predetermined modulation frequency; exciting means for exciting a specimen by directing said intensity-modulated light onto the specimen, thereby generating a photoacoustic effect in the specimen; detection means for detecting the photoacoustic effect generated in the specimen and producing a detection signal indicative of the detected photoacoustic effect; and information extracting means for extracting information about the surface and interior of the specimen from the detection signal produced by said detection means; wherein said exciting means includes a near-field optical scanning microscope, and wherein the intensity-modulated light is emitted from an aperture of the near-field optical scanning microscope while a distance between the aperture of the near-field optical scanning microscope and the surface of the specimen is maintained constant irrespective of the photoacoustic effect generated in the specimen. - View Dependent Claims (6, 7, 8)
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Specification