Device for controlled diffusion of a chemical substance
First Claim
1. A device for controlled diffusion of a chemical substance of interest between a body fluid and said device, said device comprising:
- a structure impermeable to the substance of interest, an inwardly facing surface of which surrounds and in part defines a compartment, said structure having a port defined therein; and
a diffusion layer formed in said structure characterized by selective permeability to the substance of interest while being substantially impermeable to other substances and the substance of interest bound to any of said other substances, said layer comprising at the time of formation in said compartment a dispersed solution coating substantially all of said inwardly facing surface of said structure thereby establishing said layer in adherence with said inwardly facing surface and across said port.
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Accused Products
Abstract
A device and methods of use and manufacture are disclosed for controlled diffusion of chemical substances of interest intraorally. The device includes ported structure formed of material that is substantially impermeable to the substance of interest, an inner wall of which defines a compartment communicating through the ports with the exterior of the device. A dispersed layer is formed in the compartment of material having limited permeability, the layer being formed so that contact is maintained with the inner wall across the ports after formation, the ports and the layer thus providing a region of permeability to diffusion of the chemical substance of interest. In use, either the chemical substance of interest or a composition capable of binding itself to the chemical substance of interest is placed in the compartment and the device is positioned in the mouth of a subject where it may remain for extended periods.
73 Citations
10 Claims
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1. A device for controlled diffusion of a chemical substance of interest between a body fluid and said device, said device comprising:
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a structure impermeable to the substance of interest, an inwardly facing surface of which surrounds and in part defines a compartment, said structure having a port defined therein; and a diffusion layer formed in said structure characterized by selective permeability to the substance of interest while being substantially impermeable to other substances and the substance of interest bound to any of said other substances, said layer comprising at the time of formation in said compartment a dispersed solution coating substantially all of said inwardly facing surface of said structure thereby establishing said layer in adherence with said inwardly facing surface and across said port. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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Specification